Suspected prostate CA/pancreas CA?

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Updated – January 12, 2024

If prostate CA or pancreatic CA (carcinoma) is suspected, a biopsy will either provide the longed-for relief or sobering confirmation of the suspected diagnosis.

But what can you do to prevent it effectively or even, in the early stages, to avoid an operation with significant consequences and stress?

The Heidelberg University Clinic was already addressing this question regarding prostate CA before 2013 as part of its own Research within this Pilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) – study protocol for a randomized controlled trial (as of June 3, 2014) got to the bottom. Other researchers have also addressed this question.

There is now a significant body of evidence to confirm this Studies resort to this, which turns the initially vague glimmer of hope into a clear and unmistakable light at the end of the tunnel.

Sulforaphane

Initially, hope rested on the extract Sulforaphane of broccoli seeds. For the first time in 1990 Sulforaphane at the Johns Hopkins School of Medicine isolated from broccoli in order to investigate its anticarcinogenic effects in more detail.

This effect, which was initially only hoped for, has now been confirmed: Sulforaphane can prevent the development of cancer cells and initiate apoptosis, the cell death of cancer cells from different types of cancer.

Sulforaphane is an isothiocyanate, a mustard oil obtained from enzymatic hydrolysis of the mustard oil glycoside glucoraphanin.

Effect

While well-known antioxidants such as vitamin C, E, β-carotene neutralize free radicals directly Sulforaphane another, more effective way.

It activates phase II enzymes, which trigger the body's own defense mechanisms of an antioxidant nature. Sulforaphane destroyed Microtubules, the cytoskeleton, as well as essential metabolic pathways of the tumor cells and thus leads to their destruction.

In addition to these effects, which are important for carcinomas, wait Sulforaphane with other positive properties.
This is intended, among other things, to combat the germ responsible for stomach ulcers Helicobacter pylori, as well as other germs that have become resistant to conventional antibiotics, can be effective.
A beneficial effect on total cholesterol, LDL and triglycerides, as well as liver enzymes has also been described.

Studies

Prostate CA

The title of the most current study (as of April 10, 2023) is: Sulforaphane and Its Protective Role in Prostate Cancer: A Mechanistic Approach and is available there in full text free of charge.

Another study (as of April 20, 2021) is titled Sulforaphane as a Promising Natural Molecule for Cancer Prevention and Treatment and, in addition to the short version linked here, is unfortunately only available in the full text - for a fee.

A fairly specialized study available in free full text (as of November 18, 2020) Sulforaphane Reduces Prostate Cancer Cell Growth and Proliferation In Vitro by Modulating the Cdk-Cyclin Axis and Expression of the CD44 Variants 4, 5, and 7 gives deeper insights.

For those who do not speak medical English, please refer to the German-language and basic publications from the Heidelberg University Hospital mentioned at the beginning.

Pancreas CA

The most current summary of all current findings from studies on the subject of pancreatic CA is currently (as of November 24, 2023) in the one with the title Efficacy and tolerability of sulforaphane in the therapeutic management of cancers: a systematic review of randomized controlled trials overwritten and freely available full-text publication.

Another study published in the free full text (as of May 5, 2019) Sulforaphane Induces miR135b-5p and Its Target Gene, RASAL2, thereby Inhibiting the Progression of Pancreatic Cancer also describes the disruption of the miR135b-5p/RASAL2 signaling pathway, which is important for tumor growth.

The study, which is also freely available (as of January 22, 2014) Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication deals with the dysregulation (disruption) of the communication pathway between tumor cells caused by sulforaphane.

There is also a study treating pancreatic CA (as of December 1, 2013). Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50^Cdc37 complex and direct interactions with amino acid residues of Hsp90, which is available as a free full-text version.