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Suspected prostate CA/pancreas CA?

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Updated - February 14, 2026

If prostate CA or pancreatic CA (carcinoma) is suspected, a biopsy will either provide the longed-for relief or sobering confirmation of the suspected diagnosis.

But what can you do to prevent it effectively or even, in the early stages, to avoid an operation with significant consequences and stress?

The Heidelberg University Clinic was already addressing this question regarding prostate CA before 2013 as part of its own Research within this Pilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) – study protocol for a randomized controlled trial (as of June 3, 2014) got to the bottom. Other researchers have also addressed this question.

There is now a significant body of evidence to confirm this Studies resort to this, which turns the initially vague glimmer of hope into a clear and unmistakable light at the end of the tunnel.

In addition, the i.v. administration of 75g vitamin C (in parallel with chemotherapy) in stage IV pancreatic cancer has been shown to reduce the risk of cancer in this randomized controlled trial. study the mortality risk by 54 %.

Sulforaphane

Initially, hope rested on the extract Sulforaphane of broccoli seeds. For the first time in 1990 Sulforaphane at the Johns Hopkins School of Medicine isolated from broccoli in order to investigate its anticarcinogenic effects in more detail.

This effect, which was initially only hoped for, has now been confirmed: Sulforaphane can prevent the development of cancer cells and initiate apoptosis, the cell death of cancer cells from different types of cancer.

Sulforaphane is an isothiocyanate, a mustard oil obtained from enzymatic hydrolysis of the mustard oil glycoside Glucoraphanin is obtained.

Glucoraphanin

Glucoraphanin is the stable precursor (glucosinolate) of sulforaphane. Through the enzyme Myrosinase glucoraphanin is converted into the biologically active sulforaphane during chewing, slicing or in the intestine. Unlike sulforaphane, glucoraphanin is heat and storage stable.

The enzyme myrosinase is stable in the range of 30 - 35 °C, sulforaphane up to 40 °C and glucoraphanin up to around 100 °C. Temperatures above this lead to degradation (decomposition) of the active ingredients and thus to a partial or complete loss of effectiveness.

Active ingredient content

The active ingredient content of different types of broccoli varies, as do growing conditions such as soil, minerals, climate, harvest time and storage conditions.

Adult broccoli heads - 100g fresh weight

Broccoli sprouts (sprouted for 3-5 days)

Broccoli sprouts contain 10 to 100 times more glucoraphanin than full-grown broccoli heads:

Broccoli seeds (unsprouted/raw)

Preparations available on the market

Preparations with glucoraphanin with myrosinase

These preparations contain the stable precursor glucoraphanin and the enzyme myrosinase, so that sulforaphane is only formed „on site“ in the body.

Preparations with sprout powder/granules

Preparations with sprout extract

Stabilized sulforaphane (highest bioavailability)

Dosage recommendations

Scientific studies typically use:

  • Preventive
    5-25 mg sulforaphane per day
  • Therapeutic
    30-90 mg sulforaphane per day
    Corresponds to approx. 0.4 mg sulforaphane per kg body weight

Optimization of sulforaphane formation

  • Myrosinase is destroyed at > 60°C
    Broccoli only raw or briefly steamed (< 5 minutes at < 60°C)
  • Chew thoroughly
    activates myrosinase
  • After cutting, wait approx. 40-90 minutes before heating
    triples the sulforaphane content
  • alternative
    Add mustard powder to the cooked broccoli (provides myrosinase)

Quality criteria

  • Glucoraphanin + myrosinase
    preferred (highest stability)
  • Laboratory-tested batches
    with salary slips
  • Made from broccoli seeds or sprouts
    Highest content
  • Stabilized sulforaphane (prostaphane)
    Highest bioavailability, but only available in Europe

Gut health is a prerequisite

The intestine plays the most important role in the conversion of glucoraphanin into sulforaphane. If the intestinal flora is disturbed, the conversion of the supplied glucoraphanin into the required sulforaphane cannot take place to a sufficient extent.

One possibility is a bowel cleansing / detoxification / bowel treatment or, if this would be too much of a burden for health reasons, the use of preparations with Myrosinase necessary.

Effect

While well-known antioxidants such as vitamin C, E, β-carotene neutralize free radicals directly Sulforaphane another, more effective way.

It activates phase II enzymes, which trigger the body's own defense mechanisms of an antioxidant nature. Sulforaphane destroyed Microtubules, the cytoskeleton, as well as essential metabolic pathways of the tumor cells and thus leads to their destruction.

In addition to these effects, which are important for carcinomas, wait Sulforaphane with other positive properties.
This is intended, among other things, to combat the germ responsible for stomach ulcers Helicobacter pylori, as well as other germs that have become resistant to conventional antibiotics, can be effective.
A beneficial effect on total cholesterol, LDL and triglycerides, as well as liver enzymes has also been described.

Studies

Prostate CA

For those who do not speak medical English, please refer to the German-language and basic publications from the Heidelberg University Hospital mentioned at the beginning.

Pancreas CA

Notice: If you have advanced pancreatic cancer, you should talk to your doctor, as high-dose broccoli sprout supplements can increase nausea and vomiting during chemotherapy.

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