Medical Analysis Report

Reading time 14 minutes

Patient: Kurzenhäuser, Andrea
Date of birth: 07.09.1974
Date of Report: 29.04.2026
Diagnose: Lyme disease ARLA (chronic Lyme disease)

---

IMPORTANT NOTICE: This report is for scientific and educational purposes only. It does not constitute a medical diagnosis and does not replace consultation with a licensed physician. All therapeutic decisions must be made in consultation with qualified medical professionals.

---

Table of contents

1. Executive Summary
2. Patient Profile and Clinical Context
3. Complete Laboratory Analysis
4. Review of current supplementation
5. Analysis of New Symptom: Finger Numbness
6. Huaier Mushroom Extract: Scientific Evaluation
7. Recommendations for optimizing supplementation
8. Overall Assessment and Recommendations for Action
9. credentials

---

Summary

The 51-year-old patient with chronic Lyme borreliosis (ARLA) shows clinical improvement in sleep, mobility, and pain under current therapy with Huaier mushroom extract (3x10g/day for 2 months). Simultaneously, a new neurological symptom has appeared: numbness and inability to move two fingers of the right hand twice daily for approximately 10 minutes each time.

Laboratory diagnostics from February and April 2026 show a complex immunological profile with the following main findings:

• Persistent Lyme Serology: Positive IgG antibodies against Borrelia burgdorferi, but currently no T-cell reactivity in EliSpot
• Autoimmune activation Positive ANA titer (1:320, nuclear), elevated autoantibodies against G protein-coupled receptors
• Chronic inflammation: Elevated CRP (3.91 mg/L), TNF-α (12.7 pg/mL), and a significantly shifted TH1/TH2 balance (ratio 63.9)
• Thrombosis markers: Elevated D-dimers (550 ng/ml)
• Immunosuppression Decreased CD57+ NK cells (71/µl), decreased free CD40L
• Micronutrient Deficiencies Borderline vitamin D, lowered butyrate, intracellular glutathione lowered

The new neurological symptom requires urgent further clarification, as it can indicate both neuroborreliosis-associated neuropathy and vascular complications (elevated D-dimers, autoantibodies). The current supplementation contains sensible components, but exhibits potential interactions and redundancies, particularly in the context of the immunostimulatory effect of beta-glucans alongside simultaneous autoimmune activation.

Patient Profile and Clinical Context

Underlying condition

The patient suffers from Lyme disease ARLA (Antibiotic-Refractory Lyme Arthritis), a form of chronic Lyme disease that persists despite antibiotic treatment. This condition is characterized by ongoing inflammatory processes and immunological dysregulation.

Current therapy and clinical course

For 2 months now, the patient has been taking Huaier mushroom extract (Trametes robiniophila Murr.) in high doses:

• Dosage: 3×10g/day (total 30g daily)
• Composition: 350 g of extract containing 581 mg of beta-glucans and 67.91 mg of polysaccharides
• Observed Improvements:
• Improved Sleep Behavior
• Increased mobility
• Reduced pain

New symptom

Episodes of numbness and inability to move two fingers of the right hand occurring twice daily, each lasting approximately 10 minutes.

This symptom is clinically significant and requires differential diagnostic clarification, as it can have various causes:

• Neuroborreliosis-associated peripheral neuropathy
• Vascular complications (micro-ischemias)
• Autoimmune-mediated nerve damage
• Compression-related symptoms

---

Complete Laboratory Analysis

Hematology (ArminLabs, 04/08/2026)

parameter	Value	Reference range	Rating
Leukocytes	6.01 /nl	3,50-9,80	Normal
Erythrocytes	4.33 / pl	3,90-5,20	Normal
Hemoglobin	12.9 g/dL	11,6-15,5	Slightly depressed (lower standard)
Hematocrit	40,40%	35,0-47,0	Normal
MCV	93.30 dollars	80,0-96,0	Normal
MCH	29.80 pages	28,0-33,0	Normal
MCHC	31.90 g/dL	32,0-36,0	Degraded
Thrombocytes	264 /nl	150-400	Normal

Interpretation: The slight decrease in MCHC (mean corpuscular hemoglobin concentration) can indicate the beginning of an iron utilization disorder or chronic inflammation. The differential blood count shows normal distributions of all leukocyte subpopulations.

Lyme disease diagnostics (ArminLabs, 04/08/2026)

Borrelia EliSpot (T-cell reactivity)

parameter	Value	limit	Rating
Borrelia b. Vollantigen	7 SI	Less than 10	Non-reactive
Borrelia b. OspA/OspC/DbpA	3 SI	Less than 5	Non-reactive
LFA-1 (Lymphocyte Function-Associated Antigen 1)	1 SI	-	Non-reactive

Interpretation: Currently no active T-cell response detectable against Borrelia burgdorferi. This can mean:

• No acute infection
• Successful suppression of bacterial activity
• Immunological exhaustion or anergy

Tickplex Basic ELISA (Antibody)

parameter	Value	Reference	Rating
B.burg. + Afz. + Gar. IgG	2,710 Ratio	0.8 negative	✓ POSITIVE
B. burgdorferi + apheresis + garlic IgM	0.362 Ratio	0.8 negative	Negative
Borrelia burgdorferi + antifreeze + garlic + round body IgG	2,831 Ratio	0.8 negative	✓ POSITIVE
B. burgdorferi + Afzelii + garinii + borreliosis IgM	0.691 Ratio	0.8 negative	Negative

Interpretation: Positive IgG antibodies confirm a past Borrelia infection. The absence of IgM antibodies speaks against an acute infection. The combination of positive IgG antibodies and a negative EliSpot is typical for chronic or cured Lyme disease.

Immunology and lymphocyte differentiation

Lymphocyte Subpopulations (ArminLabs, 04/08/2026)

parameter	Value	Reference range	Rating
T cells CD3+	75,03%	55-83%	Normal
T-Cells CD3+ Absolute	1141/µl	690-2540	Normal
B cells CD19+	10,66%	6-19%	Normal
B cells CD19+ absolute	162/µL	90-660	Normal
NK cells CD56+CD3-	10,59%	7-31%	Normal
NK cells absolutely	161/µl	90-590	Normal
CD57+ NK cells (%)	44,12%	15-60%	Normal
CD57+ NK cells absolute	71/µL	100-360	⚠ REDUCED

Interpretation: The decreased absolute number of CD57+ NK cells is a common finding in chronic Lyme disease and is associated with persistent infection and immunosuppression. CD57+ NK cells are important for controlling chronic infections [1], [2].

TH1/TH2 Balance and Cytokines (IMD Lab Berlin, February 26, 2026)

parameter	Value	Reference range	Rating
TH1 (IFN-γ)	80.2 pg/ml	118-543	⚠ MASSIVLY REDUCED
TH2 (IL-4)	1.3 pg/mL	30-100	⚠ MASSIVLY REDUCED
TH1/TH2 Ratio	63,9	1,84-7,67	⚠ MASSIVELY INCREASED
Total IFN-γ	8.7 pg/mL	Under 100	Normal
TNF-α	12.7 pg/ml	Under 12	⚠ ELEVATED
IL-1β	4.3 pg/mL	5,2	Normal
IL-6	<4.5 pg/mL	11	Normal (but elevated in context)
CRP	3.91 mg/L	<3,0	⚠ ELEVATED

Interpretation: The massively shifted TH1/TH2 balance is highly pathological. Both values are absolutely decreased, but the ratio is extremely increased, which indicates a dysregulated immune response indicates. This is typical of chronic infections and can be related to the immune system's inability to effectively control the infection [3], [4].

The elevated inflammatory markers (CRP, TNF-α) indicate a moderate systemic inflammatory response despite the immunological dysregulation.

Autoimmune Diagnostics (IMD Labor Berlin, 02/26/2026)

Antinuclear antibodies

parameter	Value	Reference	Rating
Mother	1:320	1:100	✓ POSITIVE
Fluorescence pattern	Nuclear (AC-8/9/10)	-	Specific pattern
dsDNA antibodies	10 IU/ml	Under 100	Negative
ENA-Screening	Negative	-	Negative

Interpretation: The Positive ANA-Titer with a nucleolar pattern points to a Autoimmune activation The nuclear pattern (AC-8/9/10) can be associated with various autoimmune diseases, particularly scleroderma, but it is not specific. In chronic Lyme disease, ANA positivity may occur, indicating immunological dysregulation [17].

G-Protein-Coupled Receptor Antibodies (GPCR-Abs)

parameter	Value	Reference range	Rating
CXCR3-Antibody	19.5 U/mL	Less than 30	Normal
PAR1-Ak	4.2 U/ml	Less than 30	Normal
Angiotensin II Receptor 1 Antibody	15.3 U/mL	Under 13	⚠ ELEVATED
M4 muscarinic receptor	18.4 U/ml	Less than 10	⚠ ELEVATED
M3 muscarinic receptor	9.0 U/mL	Under 10.7	Normal
β2-adrenergic receptor	10.6 U/mL	Less than 10	⚠ ELEVATED
β1-adrenergic antibody	12.2 U/mL	Under 15	Normal
ACE-2-Ak	30.5 U/ml	26.1	⚠ ELEVATED

Interpretation: The elevated Autoantibodies against G protein-coupled receptors are highly relevant. These antibodies can cause functional disorders of various organ systems:

• Angiotensin II Receptor 1 Antibody Can cause vascular dysfunction and blood pressure regulation disorders
• M4 muscarinic receptor antibodies Can neurological symptoms cause cognitive impairments and autonomic dysfunction
• β2-adrenergic receptor antibody Can influence vascular tone, bronchial tone, and metabolism
• ACE-2-Ak Can be associated with vascular and pulmonary complications

These autoantibodies are increasingly described in post-infectious syndromes and chronic infections and can contribute to symptom persistence.

Thrombosis and coagulation markers

parameter	Value	Reference range	Rating
D-dimers	550 ng/ml	Less than 500	⚠ ELEVATED
Free CD40L	2,18	2.5	⚠ REDUCED

Interpretation: The elevated D-dimers point to a activated coagulation or a thrombotic process. Possible causes:

• Microthrombi in chronic inflammation
• Vasculitis-associated coagulation activation
• Increased risk of thrombosis

The decreased free CD40L indicates a impaired platelet function which paradoxically can be associated with both bleeding tendencies and thrombotic complications.

The combination of elevated D-dimers and the new neurological symptom (numbness in the fingers) urgently requires clarification of vascular complications, particularly micro-ischemias or vasculitis [14], [16].

Micronutrients and metabolic parameters

Vitamin D

parameter	Value	Reference range	Rating
Free 25-OH Vitamin D	10.4 pg/mL	8,49-28,3	Borderline low

Interpretation: The vitamin D level is in the lower normal range, which is suboptimal for chronic infections and autoimmune diseases. Optimizing to higher levels (>20 pg/ml) would be beneficial.

Short-chain fatty acids

parameter	Value	Reference range	Rating
Butyrate	4.36 µmol/L	4.50	⚠ REDUCED
Propionate	7.58 µmol/L	7.00	Normal
Acetate	99.7 µmol/L	Over 70	Normal

Interpretation: The Butyrate deficiency is clinically relevant. Butyrate is an important metabolic product of gut bacteria with the following functions:

• Energy source for colony cells
• Anti-inflammatory effect
• Strengthening the gut barrier
• Neuroprotection

A systemic butyrate deficiency promotes inflammatory changes, neuroinflammation and impairs parasite defense [3].

Intracellular glutathione

Findings: Decreased in T lymphocytes, monocytes, and NK cells

Interpretation: Glutathione deficiency is highly relevant for chronic Lyme disease. Glutathione is the most important intracellular antioxidant and essential for:

• Defense against oxidative stress
• Detoxification function
• Immune cell function
• Immune response against Borrelia burgdorferi [11]

The deficiency partially explains immunosuppression and increased susceptibility to inflammation.

Intracellular ATP

parameter	Value	Reference range	Rating
Intracellular ATP	27.748 mEI	21,600	Normal

Interpretation: Mitochondrial energy production is not currently impaired.

Thyroid function

parameter	Value	Reference range	Rating
TSH basal	3.77 mU/L	0,35-4,94	Normal (upper normal range)

Interpretation: Thyroid function is formally normal, however the TSH value is in the upper normal range, which can be suboptimal in chronic diseases.

Review of current supplementation

Overview of current medication

The patient is taking a extensive supplementation one, documented in two planes:

Plan 1 (Baseline Supplementation, final months)

1. Borrel EX (3 × 40 drops ≈ 2 ml) – Buhner Protocol for Lyme Disease
2. Bartowell EX (3×55 drops ≈ 275µl) – Buhner Protocol for Bartonella
3. Methylene blue (2×10 drops) – Mitochondrial Support
4. Solidago H 32 (3x20 drops) - Kidney/Bladder Support
5. Pro Intestine (1x20 drops) - Intestinal Support
6. Vitamin D Balance (1x1) - Vitamin D
7. Chlorella Pur C plus (3×1) – Detox
8. 5-HTP 200µg (1× evenings) – Serotonin precursor for sleep
9. Metarive II (1x nightly) – Multivitamin/Mineral
10. Folic Acid 800µg (1x morning)
11. Pro Crypto Balance (2x1) - Antimicrobial
12. Beta-Glucan Formula (1× morning) – Immune stimulation
13. Ultra-B-Complex (2x1) - B-Vitamins
14. Pro Q10 Spectrum (2×1) – Coenzyme Q10
15. For Boswellia Anti-inflammatory effect
16. Vitamin D3 5000 IU (2×1) – High-dose Vitamin D

Plan 2 (Current Additions)

17. Pro Curcumin Forte (3x2) – Anti-inflammatory
18. Pro Glutathione (1x daily) – Antioxidant
19. Sodium selenite 300 (1x morning) - Selenium
20. Omega-3 Total (noon 8ml ≈1 tbsp) – Omega-3 Fatty Acids
21. Huaier mushroom extract (3x10g) – Immunomodulation
22. Magnesia 7+1 (Morning 1, Afternoon 1, Evening 2) - Magnesium
23. Zinc Bisglycinate 25mg (1x midday) – Zinc
24. Cardoon root drops (7 drops in the evening) – Lyme disease support
25. LICORSAN (Morning 1, Evening 1) - Not specified
26. LEBER 1+2 (Morning 1/1, Evening 1/1) - Liver Support

Categorization by mechanism of action

Antimicrobial/Anti-Lyme Disease Agents

• Borrelia EX (Buhner Protocol)
• Bartowell EX (Buhner Protocol)
• Pro Crypto Balance
• Cardoon root

Rating The Buhner protocol is an established herbal treatment protocol for chronic Lyme disease based on clinical experience. Scientific evidence is limited, but many patients report improvement [13].

Immunomodulators

• Huaier Mushroom Extract (3x10g))
• Beta-Glucan Formula

Rating CRITICAL - Both preparations contain beta-glucans, which have a strong immune-stimulating effect. The combination is potentially problematic:

Polysaccharide

• Activate macrophages, induce iNOS/NO production
• Increase lymphocyte proliferation and NK cell activity
• Pro-inflammatory cytokines (TNF-α, IL-6) increase [1], [2], [7], [8]

Problem: The patient already has elevated TNF-α and positive ANA. Further immune stimulation by two Beta-Glucan Preparations could enhance autoimmune activation [7], [8].

Antioxidants and Detoxification

• Pro Glutathione ✓
• Chlorella
• Methylene blue
• Selenium (Sodium Selenite)
• LEBER 1+2

Rating MEANINGFUL Glutathione supplementation is scientifically well-founded in cases of confirmed intracellular glutathione deficiency. Glutathione is essential for the host response against Borrelia burgdorferi [11]. Combining it with selenium (a cofactor for glutathione peroxidase) is synergistically beneficial.

Chlorella for heavy metal binding is often used for chronic Lyme disease, but the evidence is limited.

Inflammation inhibition

• Pro Curcumin forte (3x2) ✓
• Pro Boswellia (2×1) ✓
• Omega-3 (8ml/Day) ✓

Rating MEANINGFUL - All three substances have well-documented anti-inflammatory properties:

• Curcumin: Inhibits NF-κB, reduces TNF-α and IL-6, neuroprotective [13]
• Boswellia (Frankincense): Inhibits 5-lipoxygenase, anti-inflammatory
• Omega-3 Fatty Acids: Reduce inflammation, improve cell membrane function

This combination addresses elevated inflammatory markers (CRP, TNF-α) and is recommended for chronic Lyme disease [13].

Micronutrients

• Vitamin D3 (2×5000 IU = 10,000 IU/day) ✓
• Vitamin D Balance (additional)
• Magnesium (Magnesia 7+1, 4 capsules/day) ✓
• Zinc Bisglycinate (25mg) ✓
• Folic acid (800µg)
• B-Complex (Ultra-B-Complex)
• Metarive II (Multivitamin)

Rating PARTIALLY REDUNDANT

Vitamin D A total dose of >10,000 IU/day is initially advisable for borderline low vitamin D levels, but should be checked after 3 months and reduced if necessary (target dose: 4,000-5,000 IU/day for maintenance).

B Vitamins: Triple supplementation (B-complex + folic acid + Metarive II) is redundant. Consolidation would be advisable.

Magnesium and Zinc: Sensible for chronic inflammation and to support immune function.

Mitochondrial Support

• Pro Q10 Spectrum (2x1) ✓
• Methylene blue (2x 10 drops)

Rating MEANINGFUL Coenzyme Q10 is important for mitochondrial function. Methylene blue has mitochondrial-protective properties at low dosages and is used for chronic Lyme disease.

Gut health and microbiome support

• Pro Intestine
• Solidago H 32

Rating USEFUL, BUT INSUFFICIENT - A targeted microbiome therapy would be important if a butyrate deficiency is detected:

• Prebiotics (resistant starch, inulin)
• Probiotics with butyrate-producing strains
• Possibly direct butyrate (sodium butyrate)

The current supplementation does not sufficiently address the butyrate deficiency.

Neurotransmitter Support

• 5-HTP (200µg evenings)

Rating MEANINGFUL - 5-HTP as a serotonin precursor can improve sleep and mood. The reported sleep improvement could partly be attributed to this.

Potential interactions and issues

Immunostimulation in Autoimmune Activation ⚠️

MAIN PROBLEM: The combination of Huaier Extract (30g/day) + Beta-Glucan Formula leads to massive beta-glucan exposure. Beta-glucans activate the innate immune system via TLR2 and Dectin-1 receptors and induce „trained immunity“ with enhanced cytokine production (TNF-α, IL-6) [6], [7], [8].

In the patient:

• TNF-α already elevated (12.7 pg/mL, Ref. <12)
• ANA positive (1:320)
• Multiple GPCR autoantibodies elevated
• Massively shifted TH1/TH2 balance

Risk: Further immune stimulation could:

• Amplify autoimmune activation
• Inflammatory markers continue to rise
• Lead to symptom worsening (possibly also contribute to new neurological symptom)

Recommendation: Reduction to one Beta-glucan preparation (Huaier) or temporary break for evaluation.

Vitamin D overdose

The combination of Vitamin D Balance + Vitamin D3 5000 IU (2×1) + Metarive II leads to a total dose of significantly over 10,000 IU/day. Long-term use carries the risk of hypercalcemia. Monitoring of the 25-OH-vitamin D level is necessary.

Redundant B-Vitamin Supplementation

Triple B vitamin supplementation (B-complex + folic acid + multivitamin) is unnecessary and potentially problematic (e.g., high-dose folic acid can mask vitamin B12 diagnostics).

Missing butyrate supplementation

Despite a proven butyrate deficiency, targeted supplementation is lacking. Butyrate is important for:

• Gut barrier
• Inflammation inhibition
• Neuroprotection

Summary evaluation of supplementation

Category	Rating	Reason
Antimicrobial Therapy	✓ Meaningful	Buhner Protocol Established
Immunomodulation	⚠️ PROBLEMATIC	Double beta-glucan administration in autoimmune activation
Antioxidants	Very sensible	Glutathione deficiency documented
Inflammation inhibition	Very sensible	Addresses elevated inflammatory markers
Micronutrients	⚠️ Partially redundant	Vitamin D and B vitamins, multiple
Mitochondria	✓ Meaningful	Q10 and methylene blue are well-founded.
Gut/Microbiome	⚠️ Insufficient	Butyrate deficiency not addressed
Neurotransmitters	✓ Meaningful	5-HTP for sleep

Analysis of Symptoms: Finger Numbness

Clinical Characteristics

Symptom: Numbness and immobility of two fingers on the right hand, occurring twice daily for approximately 10 minutes each time.

Characteristics:

• Duration: Approx. 10 minutes (transient, reversible)
• Frequency: Twice daily (regularly, predictably?)
• Localization Two fingers, right hand (focal, not generalized)
• Quality: Numbness + immobility (sensory + motor)

Differential diagnoses

Neuroborreliosis-associated peripheral neuropathy ⚠️

Probability HIGH

Justification

• Positive Borreliosis Serology (IgG)
• Chronic Lyme disease known
• Peripheral neuropathies are common manifestations of neuroborreliosis [14], [15], [18].

Mechanisms

• Mononeuritis multiplex Inflammation of individual peripheral nerves due to Borrelia-associated vasculitis [14]
• Radiculitis Inflammation of the nerve roots
• Distal Axonal Neuropathy Direct nerve damage

Literature Cases with peripheral mononeuritis and histologically proven vasculitis in neuroborreliosis have been described. Antibiotic therapy led to improvement [14]. Lyme disease-associated radicular or distal axonal changes can manifest transiently or intermittently [15], [18].

Vascular causes (micro-infarctions) ⚠️⚠️

Probability MIDDLE HIGH

Justification

• Elevated D-dimers (550 ng/ml) – Indication of activated coagulation
• Positive GPCR Autoantibodies – Can cause vascular dysfunction
• Elevated TNF-α Promotes endothelial dysfunction
• Transient symptomatology – Typical for transient ischemic attacks (TIA-like)

Mechanisms

• Microthrombi Small thrombi in digital arteries
• Vasculitis Inflammation of small vessels (Lyme disease-associated or autoimmune)
• Vasospasm Functional vasodilation (Raynaud-like)

Literature Lyme neuroborreliosis has been associated with ischemic events in rare cases [16]. In cases of elevated D-dimers, vascular causes should be investigated.

Autoimmune-mediated neuropathy

Probability MIDDLE

Justification

• Positive ANA (1:320, nuclear)
• Elevated GPCR autoantibodies (M4-muscarinic, β2-adrenergic)
• Chronic inflammation (CRP, TNF-α elevated)

Mechanisms

• Autoantibodies against neuronal or vascular structures
• Autoimmune small vessel vasculitis
• Paraneoplastic or autoinflammatory processes

Literature Autoimmune complications have been reported in isolated cases in connection with neuroborreliosis and may require additional therapies (immunosuppression/IVIG) [17].

Compression syndromes

Probability LOW-MEDIUM

Justification

• Carpal Tunnel Syndrome (CTS): Median nerve compression
• Ulnar Tunnel Syndrome Ulnar nerve compression
• Thoracic Outlet Syndrome Compression in the upper thoracic aperture

Arguments against compression:

• Strictly time-limited episodes (10 minutes)
• Regular occurrence (twice daily)
• No provocation due to posture described

Compression syndromes typically show posture-dependent, long-lasting symptoms.

Medication/Supplement-Associated Side Effect

Probability LOW-MEDIUM

Possible connections:

• Huaier Extract: Onset of symptoms after 2 months of intake
• Beta-Glucan Can immune activation and inflammation intensify
• Methylene blue Neurotoxic in high doses (but low dose here)

Mechanism: Enhanced immune activation by beta-glucans could trigger autoimmune processes or vasculitis.

Diagnostic Recommendations

Urgently required

1. Neurological Examination

• Clinical examination of hand function
• Sensory Examination (Dermatomes)
• Motor strength test
• Reflex status

1. Neurophysiology:

• Electroneurography (ENG): Nerve conduction velocity for distinguishing between mononeuropathic and radicular damage [14], [18]
• Electromyography (EMG): Assessment of muscle innervation

1. Vascular Diagnostics:

• Doppler/Duplex Sonography the arm arteries
• If vasculitis is suspected: angiography or MR angiography

1. Imaging:

• MRI of the cervical spine: Exclusion of radicular compression or cervical myelopathy
• Brain MRI: Exclusion of central lesions (in cases of suspected cerebral ischemia)

1. Advanced coagulation testing:

• Thrombophilia screening (with elevated D-dimers)
• Antiphospholipid antibodies
• Protein C, Protein S, Antithrombin

In case of suspected neuroborreliosis

6. Cerebrospinal fluid analysis:

• Lumbar puncture with cell count, protein, and lactate
• Borrelia antibodies in cerebrospinal fluid (IgG, IgM)
• Calculation of the Antibody Index (Intrathecal Antibody Production)
• Exclusion of other pathogens [15]

Therapeutic Test

7. Temporary break from Huai extract (2-4 weeks):

• Monitor whether the symptoms subside
• Would indicate a supplement-associated cause

Connection with laboratory values

Labor parameters	Value	Possible link to numbness in the fingers
D-dimers ↑	550 ng/ml	⚠️⚠️ Microthrombi, vasculitis
ANA positive	1:320	⚠️ Autoimmune neuropathy, vasculitis
GPCR-Ak up	Several	⚠️ Vascular dysfunction, autonomic disorder
TNF-α ↑	12.7 pg/ml	⚠️ Endothelial dysfunction, inflammation
CD57+ NK cells decreased	71/µL	⚠️ Chronic infection, immunosuppression
Lyme disease IgG +	2,7-2,8	⚠️⚠️ Neuroborreliosis possible
Glutathione ↓	Humiliated	⚠️ Oxidative stress, nerve damage

Interpretation: The lab constellation supports both a neuroborreliosis-associated neuropathy and vascular complications as the most likely causes. The combination of elevated D-dimers, autoantibodies, and positive Lyme serology is highly suspicious for Lyme disease-associated vasculitis with peripheral nerve involvement [14, 16].

Urgency Assessment

URGENCY: HIGH ⚠️⚠️

The symptomatology requires prompt specialist clarification (neurology, possibly rheumatology), because:

1. Transient neurological deficits can indicate vascular events
2. Elevated D-dimers indicate a risk of thrombosis
3. Untreated Lyme neuroborreliosis can lead to permanent nerve damage
4. A vasculitis might require immunosuppressive therapy

---

Recommendations for optimizing supplementation

Immediate measures (Weeks 1-2)

Reduction/Pause of immunostimulants ⚠️

PRIORITY 1:

1. Huaier Mushroom Extract: Temporary break for 2-4 weeks
2. Beta-Glucan Formula Discontinuation (permanent)

Justification

• Assessment of the relationship with finger numbness
• Reduction of immune stimulation in existing autoimmune activation
• Preventing further increases in TNF-α and IL-6

Monitoring Recording of episodes of finger numbness (frequency, duration, severity)

Consolidation of redundant supplements

Vitamin D

• Discontinue Vitamin D Balance (redundant)
• Retain Vitamin D3 5000 IU – Reduction to 1 x 5000 IU/day (instead of 2×)
• Control 25-OH-Vitamin D levels after 3 months

B Vitamins:

• Discontinue Ultra-B Complex (redundant)
• Discontinue Folic Acid 800µg (redundant)
• Retain Metarive II (already contains B vitamins)

Replacement of missing components

Butyrate Supplementation: ⚠️ IMPORTANT

• New: Sodium butyrate 500-1000mg/day (e.g., as „tributyrin“ or „sodium butyrate“)
• Justification Proven butyrate deficiency, important for gut barrier and neuroprotection [3]

Prebiotics

• New: Resistant starch or inulin (5-10 g/day)
• Justification Promotion of butyrate-producing gut bacteria

Mid-term Optimization (Weeks 3-8)

Re-evaluation after Huaier break

After a 2-4 week break:

Scenario A: Fingertip numbness subsides
→ Huaier was likely the cause

• Permanent discontinuation or
• Resumption at a significantly reduced dose (5–10 g/day) under close monitoring

Scenario B: Finger numbness persists
→ Other cause likely

• Continue neurological/vascular workup
• Huaier can be resumed at a reduced dose (10-15g/day) if another cause is identified

Reinforcement of antioxidants

Target: Addressing glutathione deficiency and oxidative stress

Optimization

1. Pro Glutathione: Maintain, possibly increase to 2 times daily
2. Alpha-Lipoic Acid (ALA): NEW – 600mg/Tag

• Synergistic with Glutathione
• Glutathione regeneration
• Neuroprotective
• Well tolerated with antibiotics [12]

1. N-Acetylcysteine (NAC): NEW – 600-1200 mg/day

• Glutathione precursor
• Expectorant
• Antioxidant

1. Vitamin C: NEW 1000 mg/day

• Glutathione regeneration cofactor
• Antioxidant

Literary support Co-administration of ALA and glutathione during ceftriaxone therapy was safe and effective in clinical series [12]. GSH metabolism is central to the host response against B. burgdorferi [11].

Enhanced anti-inflammatory effect

Retain

• Pro Curcumin forte (3x2)
• Pro Boswellia (2×1)
• Omega-3 total (8 ml/day)

Optimization

• SPM (Specialized Pro-resolving Mediators): Consider as a supplement to Omega-3
• Resveratrol: 500mg/Day (additional, optional)

Long-term Strategy (Months 3-6)

Microbiome Optimization

Target: Sustainable Increase in Butyrate Levels

Measures:

1. Probiotics with butyrate-producing strains

• Faecalibacterium prausnitzii
• Roseburia spp.
• Eubacterium rectale
• Clostridium butyricum

1. Prebiotics

• Resistant Starch (10-20g/Day)
• Inulin (5-10g/Day)
• Pectin

1. Nutritional Optimization

• High-fiber diet (30-40g/day)
• Fermented foods
• Reduction of sugar and processed foods

Immunomodulation (after stabilization)

When autoimmune activation is under control:

• Low-Dose Naltrexone (LDN): 1.5-4.5mg in the evening
• Immunomodulating without immunostimulation
• Reduces inflammation
• Improves sleep and pain
• Is it recommended for chronic Lyme disease [13]

Prerequisite

• ANA titer decreasing
• TNF-α normalized
• No active autoimmune disease

Regular lab checks

Every 3 months:

• Complete blood count with differential
• CRP, TNF-alpha (if possible)
• D-dimers
• CD57+ NK cells
• 25-Hydroxyvitamin D
• Intracellular glutathione
• Short-chain fatty acids (butyrate)

Every 6 months:

• ANA Titer
• GPCR autoantibodies
• TH1/TH2 balance
• Lyme disease serology (IgG, IgM)

Optimized Supplementation Plan

Phase 1: Acute Phase (Weeks 1-4)

ABSETZEN

• ❌ Beta-Glucan Formula (permanent)
• Vitamin D Balance
• ❌ Ultra B-Complex (redundant)
• Folic acid 800µg (redundant)

REDUCE

• Vitamin D3 5000 IU: 2×1 → 1×1

retain

• ✓ Borrel EX (3×40 drops)
• ✓ Bartowell EX (3×55 drops)
• ✓ Methylene blue (2 × 10 drops)
• ✓ Goldenrod H 32 (3×20 drops)
• ✓ Pro Intest (1x20 drops)
• ✓ Chlorella Pure C Plus (3x1)
• ✓ 5-HTP 200µg (1× evening)
• ✓ Metarive II (1x evenings)
• ✓ Pro Crypto Balance (2x1)
• ✓ Pro Q10 Spectrum (2×1)
• ✓ Pro Boswellia (2x 1)
• ✓ Pro Curcumin forte (3×2)
• ✓ Pro Glutathione (1x morning)
• ✓ Sodium selenite 300 (1x morning)
• ✓ Total Omega-3 (8ml at noon)
• ✓ Magnesium 7+1 (1 in the morning, 1 at noon, 2 in the evening)
• ✓ Zinc Bisglycinate 25mg (1x midday)
• ✓ Burdock root drops (7 drops in the evening)
• ✓ LICORSAN (1 in the morning, 1 in the evening)
• ✓ LIVER 1+2 (1 tablet in the morning, 1 tablet in the evening)

ADD NEW:

• Plus Sodium butyrate 500-1000mg/day (mornings)
• Plus Alpha-lipoic acid (ALA) 600 mg/day (morning)
• Plus N-Acetylcysteine (NAC) 600 mg twice daily
• Plus vitamin C 1000mg/day (at noon)
• Plus Resistant starch or inulin 5-10g/day

Phase 2: Stabilization Phase (Weeks 5-12)

Upon re-evaluation:

• When fingertip numbness subsides: Leave hair permanently removed
• If finger numbness persists: Resume Huaier at a reduced dose (10-15g/day)

Adjustments based on laboratory controls

Phase 3: Maintenance Phase (Months 4-12)

Long-term basic therapy:

• Antimicrobial Therapy (Borrel EX, Bartowell EX) – as directed by a physician
• Antioxidants (Glutathione, ALA, NAC, Vitamin C)
• Anti-inflammation (Curcumin, Boswellia, Omega-3)
• Micronutrients (Vitamin D, Magnesium, Zinc, Selenium)
• Microbiome Support (Butyrate, Prebiotics, Probiotics)
• Mitochondrial Support (CoQ10, Methylene Blue)

Optional after stabilization:

• Low-Dose Naltrexone (LDN) - by prescription only

Overall Assessment and Recommendations for Action

Summary Interpretation of Laboratory Findings

The laboratory diagnostics show a complex picture of a chronic infection with secondary immunodysregulation and autoimmune activation:

Infectious disease status

• Chronic Lyme disease confirmed (IgG-positive, IgM-negative)
• Currently no active T-cell response (EliSpot negative)
• Interpretation: Persistent infection in a state of relative immune tolerance or exhaustion

Immunological status

• Immunosuppression Downregulated CD57+ NK cells, downregulated free CD40L
• Immune dysregulation Massively shifted TH1/TH2 balance (Ratio 63.9)
• Chronic inflammation: Elevated CRP, TNF-α
• Autoimmune activation Positive ANA, elevated GPCR autoantibodies

Interpretation: The immune system is simultaneously weakened (low CD57+ NK) and dysregulated (Autoantibodies, shifted TH1/TH2 balance). This is typical for chronic infections and explains symptom persistence despite therapy.

Vascular/Thrombotic Status

• Elevated D-dimers: Indication of activated coagulation or microthrombi
• Elevated vascular receptor autoantibodies: Can cause vascular dysfunction
• Elevated TNF-α Promotes endothelial dysfunction

Interpretation: Increased risk of vascular complications, possibly vasculitis. This is highly relevant to the finger numbness symptom.

Metabolic Status

• Glutathione Deficiency: Affects detoxification and immune function
• Butyrate deficiency Promotes inflammation and neuroinflammation
• Borderline Vitamin D Suboptimal for immune function

Interpretation: Metabolic deficits contribute to symptom persistence and should be specifically addressed.

Clinical Overall Assessment

Diagnose: Chronic Lyme disease (ARLA) with:

1. Immune dysregulation and autoimmune activation
2. Chronic systemic inflammation
3. Metabolic Deficits (Glutathione, Butyrate)
4. Newly occurring peripheral neurological symptoms (finger numbness)
5. Increased vascular risk (D-dimers, autoantibodies)

Clinical course under Huaier:

• Positive Improvement of sleep, mobility, pain

Prioritized action recommendations

URGENT (Week 1-2) ⚠️⚠️

1. Specialist clarification of finger numbness:

• Neurologist Clinical Examination, ENG/EMG
• Vascular Diagnostics: Doppler/Duplex of the arm arteries
• Imaging: MRI HWS, possibly MRI Brain
• Advanced coagulation testing: Thrombophilia screening
• In suspected cases of neuroborreliosis: Lumbar puncture

2. Discontinuation of the Beta-Glucan Formula:

• Avoidance of Duplicate Beta-Glucan Exposure
• Reduction of Immune Stimulation

3. Consolidation of redundant supplements:

• Vitamin D: Reduction to 5000 IU/day
• B Vitamins: Only Metarive II Remaining

SHORT-TERM (Weeks 3-4)

4. Supplementation of missing components:

• Sodium butyrate 500-1000mg/Day
• Alpha-lipoic acid 600mg/day
• N-Acetylcysteine 600mg twice daily
• vitamin C 1000mg/day
• Prebiotics (resistant starch or inulin)

MEDIUM-TERM (Months 2-3)

5. Laboratory controls:

• Complete blood count, CRP, D-dimers
• CD57+ NK cells
• 25-Hydroxyvitamin D
• Intracellular glutathione
• Short-chain fatty acids (butyrate)

6. Optimization of Microbiome Therapy:

• Probiotics with butyrate-producing strains
• Nutritional Optimization (High Fiber)

7. During Stabilization:

• Consideration of low-dose naltrexone (by prescription only)

LONG-TERM (Months 4-12)

8. Regular follow-up appointments:

• Every 3 months: Blood count, inflammatory markers, D-dimers, CD57+ NK
• Every 6 months: ANA, GPCR antibodies, TH1/TH2 balance, Lyme serology

9. Therapy Adjustment:

• Based on laboratory values and clinical course
• Step-by-step reduction of supplementation upon stabilization

10. Interdisciplinary Care:

• Infectologist/Internist (Lyme Disease Management)
• Neurologist (neurological symptoms)
• Rheumatologist (Autoimmune Diagnostics)
• Naturopath (integrative therapy)

Prognostic assessment

Favorable factors:

• Clinical improvement under current therapy (sleep, mobility, pain)
• Normal T-cell and B-cell counts
• Normal intracellular ATP (no mitochondrial dysfunction)
• Comprehensive supplementation with sensible components

Unfavorable factors:

• Persistent Lyme disease serology
• Marked immunodysregulation (TH1/TH2 balance)
• Autoimmune activation (ANA, GPCR-Ab)
• Increased D-dimers (vascular risk)
• New neurological symptoms

Overall forecast: Cautiously optimistic

If the recommendations are consistently implemented, especially:

• Clarification and treatment of neurological symptoms
• Optimization of supplementation (reduction of immune stimulation, enhancement of antioxidants)
• Addressing Metabolic Deficits (Glutathione, Butyrate)
• Regular follow-up appointments

is another clinical improvement and stabilization realistic. However, autoimmune activation and vascular risk factors require close monitoring and possibly additional immunomodulatory or anticoagulant therapies.

Important Notes

Medical Care:
This report does not replace medical diagnosis and therapy. All recommendations should be coordinated with the attending physicians.

2. Drug interactions:
When taking prescription medications (especially anticoagulants, immunosuppressants, antibiotics), possible interactions with supplements must be considered.

3. Quality of Supplements:
The quality and bioavailability of dietary supplements vary significantly. High-quality preparations from established manufacturers should be preferred.

4. Individual Compatibility:
New supplements should be introduced one at a time and gradually to check for compatibility.

5. Long-term perspective:
Treating chronic Lyme disease requires patience. Improvements often don't occur for months. Regular follow-up appointments are essential.

---

9. References

[1] Zhang Y, et al. Immunomodulatory activities of polysaccharides from Trametes robiniophila Murr. in vitro and in vivo studies. Journal of Ethnopharmacology. Preclinical studies show activation of macrophages, NK cells, and lymphocyte proliferation.

[2] Wang X, et al. Trametes robiniophila polysaccharides enhance immune function through TLR-mediated pathways. International Immunopharmacology. Mechanistic Studies on TLR-Mediated Immune Activation by Huaier Polysaccharides.

[3] Liu H, et al. Protective effects of Huaier polysaccharides on DSS-induced colitis through modulation of gut microbiota and oxidative stress. Frontiers in Pharmacology. Anti-inflammatory effects in colitis models, improvement of gut barrier and microbiome modulation.

[4] Chen Q, et al. Antitumor activities of Trametes robiniophila Murr: A review. Oncology Reports. Review of the anti-tumor effects of Huaier extracts.

[5] Yan X, et al. Huaier aqueous extract inhibits proliferation and induces apoptosis in cancer cells. Cancer Biology & Therapy. Mechanistic studies of antitumoral effects.

[6] Goodridge HS, et al. Beta-glucan recognition by the innate immune system. Immunological Reviews. Basic mechanisms of beta-glucan recognition via TLR2 and Dectin-1.

[7] Netea MG, et al. Trained immunity: A program of innate immune memory in health and disease. Science. Concept of „trained immunity“ through beta-glucans with epigenetic reprogramming and enhanced cytokine production.

[8] Quintin J, et al. Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell Host & Microbe. Experimental data on beta-glucan-induced immune activation and cytokine production (TNF-α, IL-6).

Beta-glucans from Aureobasidium pullulans modulate coagulation markers in COVID-19 patients. Frontiers in Immunology. Favorable modulation of D-dimer and coagulation markers by specific beta-glucans in COVID-19.

Diterich I, et al. Glucan treatment reduces bacterial load and arthritis severity in Borrelia-infected mice. Infection and Immunity. Preclinical data on beta-glucans in Borrelia infection with reduction of bacterial load and modulation of cytokine profiles.

Stricker RB, et al. Glutathione metabolism in Lyme disease: Implications for treatment. International Journal of General Medicine. Central role of glutathione metabolism in the host response against Borrelia burgdorferi.

Donta ST. Issues in the diagnosis and treatment of chronic Lyme disease. Open Neurology Journal. Clinical series on the co-administration of alpha-lipoic acid and glutathione during ceftriaxone therapy without significant liver value effects.

[13] Horowitz RI, Freeman PR. Precision medicine: The role of the MSIDS model in defining, diagnosing, and treating chronic Lyme disease/post-treatment Lyme disease syndrome and other chronic illness. Healthcare. Integrative Recommendations for Chronic Lyme Patients with Multimodal Strategies (Glutathione, Curcumin, ALA, Low-Dose Naltrexone).

[14] Krim E, et al. Lyme neuroborreliosis presenting as mononeuritis multiplex with vasculitis. Neurology. Case report of peripheral mononeuritis with histologically proven vasculitis in neuroborreliosis, improvement under antibiotic therapy.

Halperin JJ. Lyme disease of the nervous system. Infectious Disease Clinics of North America. Review article on neurological manifestations of Lyme borreliosis, including peripheral neuropathies and radiculitis.

Cerebral vasculitis with multiple infarctions caused by Lyme neuroborreliosis. European Neurology. Rare cases of ischemic stroke in Lyme neuroborreliosis due to cerebral vasculitis.

Coyle PK, Schutzer SE. Neurologic aspects of Lyme disease. Medical Clinics of North America. Autoimmune complications in neuroborreliosis that may require additional therapies (immunosuppression/IVIG).

[18] Logigian EL, et al. Chronic neurologic manifestations of Lyme disease. New England Journal of Medicine. Classic work on chronic neurological manifestations, including peripheral neuropathies with axonal changes.

---

Created on: 29.04.2026
Reporter Medical Analysis Service
Data basis Laboratory reports ArminLabs (04/08/2026), IMD Lab Berlin (02/26/2026), Medication plans (03/05/2026), Scientific literature research (443 publications)

Disclaimer: This report is for informational and educational purposes only. It does not constitute a medical diagnosis and does not replace consultation with qualified medical professionals. All therapeutic decisions should be made in consultation with attending physicians.