{"id":12789,"date":"2026-02-19T18:18:00","date_gmt":"2026-02-19T18:18:00","guid":{"rendered":"https:\/\/csiag.de\/?p=12789"},"modified":"2026-02-21T06:07:24","modified_gmt":"2026-02-21T06:07:24","slug":"%e5%85%8d%e7%96%ab%e7%bb%86%e8%83%9e%e7%96%97%e6%b3%95","status":"publish","type":"post","link":"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/","title":{"rendered":"\u514d\u75ab\u7ec6\u80de\u7597\u6cd5"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u5f55<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_Immunsystem_%E2%80%93_was_macht_das\" >\u514d\u75ab\u7cfb\u7edf--\u5b83\u80fd\u505a\u4ec0\u4e48\uff1f<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Was_Immunzelltherapie_macht\" >\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u7684\u4f5c\u7528<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_Geniale_daran\" >\u5b83\u7684\u5929\u624d\u4e4b\u5904<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Die_drei_Typen_%E2%80%93_ganz_einfach\" >\u4e09\u79cd\u7c7b\u578b--\u975e\u5e38\u7b80\u5355<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#T-Zellen_und_ihre_Rolle\" >T \u7ec6\u80de\u53ca\u5176\u4f5c\u7528<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Tumorimmunologie-Grundprinzip\" >\u80bf\u7624\u514d\u75ab\u5b66\u7684\u57fa\u672c\u539f\u7406<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#CAR-T-Zelltherapie_%E2%80%93_Konstruktion_und_Mechanismus\" >CAR-T \u7ec6\u80de\u7597\u6cd5--\u8bbe\u8ba1\u4e0e\u673a\u5236<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Molekularer_Aufbau_des_CAR\" >CAR \u7684\u5206\u5b50\u7ed3\u6784<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Herstellungsprozess_Autolog\" >\u5236\u9020\u5de5\u827a\uff08\u81ea\u4f53\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Wirkmechanismus_Effektorphase\" >\u4f5c\u7528\u673a\u5236\u548c\u6548\u5e94\u9636\u6bb5<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#TCR-T-Zelltherapie_Die_entscheidenden_Unterschiede\" >TCR-T \u7ec6\u80de\u7597\u6cd5\uff1a\u4e3b\u8981\u533a\u522b<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Warum_TCR_und_nicht_CAR_fur_intrazellulare_Antigene\" >\u7ec6\u80de\u5185\u6297\u539f\u4e3a\u4ec0\u4e48\u662f TCR \u800c\u4e0d\u662f CAR\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Struktur_des_therapeutischen_TCR\" >\u6cbb\u7597\u6027 TCR \u7684\u7ed3\u6784<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#TIL-Therapie_%E2%80%93_Prinzip_der_naturlichen_Tumorerkennung\" >TIL\u7597\u6cd5--\u81ea\u7136\u80bf\u7624\u68c0\u6d4b\u539f\u7406<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Biologische_Grundlage\" >\u751f\u7269\u5b66\u57fa\u7840<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Herstellungsprozess_Lifileucel\" >\u751f\u4ea7\u5de5\u827a\uff08Lifileucel\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Herausforderungen_%E2%80%93_aktuelle_Forschungsansatze\" >\u6311\u6218--\u5f53\u524d\u7684\u7814\u7a76\u65b9\u6cd5<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Antigen-Escape\" >\u6297\u539f\u9003\u9038<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#T-Zell-Erschopfung_Exhaustion\" >T \u7ec6\u80de\u8870\u7aed\uff08\u8870\u7aed\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Tumormikroumgebung_TME\" >\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Zytokinsturm_CRS_ICANS\" >\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\uff08CRS\uff09\u548c ICANS<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Allogene_%E2%80%9EOff-the-shelf%E2%80%9C-Therapien\" >\u5f02\u4f53 \u201e\u73b0\u6210 \u201c\u7597\u6cd5<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#27_Quantitative_Wirksamkeitsdaten_im_Uberblick\" >2.7 \u91cf\u5316\u6210\u6548\u6570\u636e\u6982\u89c8<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Weiterfuhrende_Literatur_Ressourcen\" >\u66f4\u591a\u9605\u8bfb\u548c\u8d44\u6e90<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Weltweit_zugelassene_Immunzelltherapien\" >\u5168\u7403\u8ba4\u53ef\u7684\u514d\u75ab\u7ec6\u80de\u7597\u6cd5<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Einleitung_Die_drei_grosen_Klassen\" >\u5bfc\u8a00\uff1a\u4e09\u5927\u7c7b<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#CAR-T-ZELLTHERAPIEN\" >CAR-T \u7ec6\u80de\u7597\u6cd5<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Tisagenlecleucel_Kymriah%C2%AE_%E2%80%93_Novartis\" >Tisagenlecleucel (Kymriah\u00ae) - Novartis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Axicabtagene_Ciloleucel_Yescarta%C2%AE_%E2%80%93_KiteGilead\" >Axicabtagene ciloleucel (Yescarta\u00ae) - Kite\/Gilead<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Brexucabtagene_Autoleucel_Tecartus%C2%AE_%E2%80%93_KiteGilead\" >Brexucabtagene Autoleucel (Tecartus\u00ae) - Kite\/Gilead<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Lisocabtagene_Maraleucel_Breyanzi%C2%AE_%E2%80%93_Bristol_Myers_Squibb\" >Lisocabtagene Maraleucel (Breyanzi\u00ae) - Bristol Myers Squibb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Idecabtagene_Vicleucel_Abecma%C2%AE_%E2%80%93_Bristol_Myers_Squibb_2seventy_bio\" >Idecabtagene Vicleucel (Abecma\u00ae) - Bristol Myers Squibb \/ 2seventy bio<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Ciltacabtagene_Autoleucel_Carvykti%C2%AE_%E2%80%93_JanssenLegend_Biotech\" >Ciltacabtagene Autoleucel (Carvykti\u00ae) - Janssen\/Legend Biotech<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Obecabtagene_Autoleucel_Aucatzyl%C2%AE_%E2%80%93_Autolus_neu_112024\" >Obecabtagene Autoleucel (Aucatzyl\u00ae) - Autolus\uff08\u65b0\uff1a11.2024\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#WELTWEIT_ZUGELASSEN_%E2%80%93_NICHT_IN_USAEU_weitere_Lander\" >\u5168\u7403\u5141\u8bb8 - \u7f8e\u56fd\/\u6b27\u76df\uff08\u5176\u4ed6\u56fd\u5bb6\uff09\u4e0d\u5141\u8bb8<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#China_NMPA_%E2%80%93_vier_zusatzliche_CAR-T-Produkte\" >\u4e2d\u56fd\uff08NMPA\uff09--\u65b0\u589e\u56db\u79cd CAR-T \u4ea7\u54c1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-37\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Indien_CDSCO\" >\u5370\u5ea6\uff08CDSCO\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-38\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#TCR-T-ZELLTHERAPIEN_zugelassen\" >TCR-T \u7ec6\u80de\u7597\u6cd5\uff08\u5df2\u83b7\u6388\u6743\uff09<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-39\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Afamitresgene_Autoleucel_Tecelra%C2%AE_%E2%80%93_Adaptimmune_August_2024\" >Afamitresgene Autoleucel (Tecelra\u00ae) - Adaptimmune\uff082024 \u5e74 8 \u6708\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-40\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Tebentafusp-tebn_Kimmtrak%C2%AE_%E2%80%93_Immunocore_Januar_2022\" >Tebentafusp-tebn (Kimmtrak\u00ae) - Immunocore\uff082022 \u5e74 1 \u6708\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-41\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#TIL-THERAPIE_zugelassen\" >TIL-THERAPY \uff08\u6388\u6743\uff09<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-42\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Lifileucel_Amtagvi%C2%AE_%E2%80%93_Iovance_Biotherapeutics_Februar_2024\" >Lifileucel (Amtagvi\u00ae) - Iovance Biotherapeutics\uff082024 \u5e74 2 \u6708\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-43\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Ubersicht_aller_Immunzelltherapien_weltweit\" >\u5168\u7403\u6240\u6709\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u6982\u89c8<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-44\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Nebenwirkungen_%E2%80%93_Was_alle_Therapien_verbindet\" >\u526f\u4f5c\u7528--\u6240\u6709\u7597\u6cd5\u7684\u5171\u540c\u70b9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-45\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Wo_werden_diese_Therapien_in_Deutschland_angeboten\" >\u8fd9\u4e9b\u7597\u6cd5\u5728\u5fb7\u56fd\u54ea\u4e9b\u5730\u65b9\u63d0\u4f9b\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-46\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Ausblick_Was_kommt_als_nachstes\" >\u5c55\u671b\uff1a\u4e0b\u4e00\u6b65\u662f\u4ec0\u4e48\uff1f<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-47\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#GKV-Erstattung_von_Immunzelltherapien_in_Deutschland\" >\u5fb7\u56fd\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u7684 SHI \u62a5\u9500<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-48\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#CAR-T-Zelltherapien\" >CAR-T \u7ec6\u80de\u7597\u6cd5<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-49\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#AMNOG_NUB-Verfahren\" >AMNOG \u548c NUB \u7a0b\u5e8f<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-50\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Fruhe_Nutzenbewertung_durch_den_G-BA\" >G-BA \u7684\u65e9\u671f\u6548\u76ca\u8bc4\u4f30<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-51\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Preisverhandlung_nach_%C2%A7_130b_SGB_V\" >\u6839\u636e \u00a7 130b SGB V \u8fdb\u884c\u4ef7\u683c\u8c08\u5224<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-52\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#NUB-Verfahren_fur_Krankenhauser\" >\u533b\u9662\u7684 NUB \u7a0b\u5e8f<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-53\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Die_Realitat_Einzelfallantrage_und_Burokratie\" >\u73b0\u5b9e\uff1a\u4e2a\u4eba\u7533\u8bf7\u548c\u5b98\u50da\u4e3b\u4e49<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-54\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_%E2%80%9EPay-for-Outcome%E2%80%9C-Modell\" >\u6309\u6210\u679c\u4ed8\u8d39 \u201e\u6a21\u5f0f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-55\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Welche_CAR-T-Produkte_sind_in_Deutschland_erstattungsfahig\" >\u54ea\u4e9b CAR-T \u4ea7\u54c1\u5728\u5fb7\u56fd\u7b26\u5408\u62a5\u9500\u6761\u4ef6\uff1f<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-56\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Kimmtrak_Tebentafusp_%E2%80%93_Sonderfall\" >Kimmtrak\uff08Tebentafusp\uff09--\u7279\u4f8b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-57\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#TIL-Therapie_Lifileucel_Amtagvi_%E2%80%93_In_Deutschland_derzeit_NICHT_erstattungsfahig\" >TIL\u7597\u6cd5\uff08Lifileucel\/Amtagvi\uff09--\u76ee\u524d\u5728\u5fb7\u56fd\u4e0d\u4e88\u62a5\u9500<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-58\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#TCR-T-Therapien_Afami-cel_Tecelra_%E2%80%93_In_Europa_nicht_zugelassen\" >TCR-T \u7597\u6cd5\uff08Afami-cel \/ Tecelra\uff09--\u672a\u83b7\u6b27\u6d32\u6388\u6743<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-59\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Was_tun_wenn_die_Kasse_ablehnt_Rechtliche_Moglichkeiten\" >\u5982\u679c\u4fdd\u9669\u516c\u53f8\u62d2\u7edd\uff0c\u8be5\u600e\u4e48\u529e\uff1f\u6cd5\u5f8b\u9009\u62e9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-60\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Osterreich\" >\u5965\u5730\u5229<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-61\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Schweiz\" >\u745e\u58eb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-62\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Zusammenfassung\" >\u6458\u8981<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-63\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#PKV_und_Immunzelltherapie_%E2%80%93_Die_vollstandige_Rechtslage\" >PKV \u548c\u514d\u75ab\u7ec6\u80de\u7597\u6cd5--\u5b8c\u6574\u7684\u6cd5\u5f8b\u72b6\u51b5<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-64\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_rechtliche_Fundament_%C2%A7_192_VVG_und_MBKK_2009\" >\u6cd5\u5f8b\u57fa\u7840\uff1a\u00a7 192 VVG \u548c MB\/KK 2009<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-65\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Der_Schlusselbegriff_%E2%80%9EMedizinisch_notwendige_Heilbehandlung%E2%80%9C\" >\u5173\u952e\u672f\u8bed\uff1a\u201e\u533b\u7597\u5fc5\u9700\u7684\u6cbb\u7597\u201c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-66\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_Richtungsurteil_OLG_Frankfurt_29062022_%E2%80%93_Az_7_U_14021\" >\u91cc\u7a0b\u7891\u5f0f\u7684\u5224\u51b3\uff1a\u6cd5\u5170\u514b\u798f\u5730\u65b9\u6cd5\u9662\uff0c2022 \u5e74 6 \u6708 29 \u65e5 - \u7f16\u53f7 7 U 140\/21<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-67\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_%E2%80%9Eauffallige_Missverhaltnis%E2%80%9C_nach_%C2%A7_192_Abs_2_VVG_%E2%80%93_und_warum_es_bei_CAR-T_nicht_greift\" >VVG \u7b2c 192 \u6761\u7b2c 2 \u6b3e\u89c4\u5b9a\u7684 \u201e\u660e\u663e\u4e0d\u76f8\u79f0\u201c--\u4ee5\u53ca\u4e3a\u4f55\u4e0d\u9002\u7528\u4e8e CAR-T<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-68\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_Voranfrageverfahren_nach_%C2%A7_192_Abs_8_VVG_%E2%80%93_der_wichtigste_praktische_Schritt\" >VVG \u7b2c 192 (8) \u6761\u89c4\u5b9a\u7684\u521d\u6b65\u8c03\u67e5\u7a0b\u5e8f--\u6700\u91cd\u8981\u7684\u5b9e\u9645\u6b65\u9aa4<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-69\" href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/#Bei_Ablehnung_Rechtsmittel_und_Klage\" >\u5982\u679c\u88ab\u62d2\u7edd\uff1a\u4e0a\u8bc9\u548c\u6cd5\u5f8b\u8bc9\u8bbc<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u9605\u8bfb\u65f6\u95f4<\/span> <span class=\"rt-time\"> 20<\/span> <span class=\"rt-label rt-postfix\">\u5206\u949f<\/span><\/span>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_Immunsystem_%E2%80%93_was_macht_das\"><\/span>\u514d\u75ab\u7cfb\u7edf--\u5b83\u80fd\u505a\u4ec0\u4e48\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u514d\u75ab\u7cfb\u7edf\u62e5\u6709\u4e00\u6574\u652f\u7531\u4fa6\u5bdf\u5175\u3001\u6218\u6597\u673a\uff08\u5982......\uff09\u7ec4\u6210\u7684\u519b\u961f\u3002<em>T \u7ec6\u80de<\/em>)\u548c\u52a9\u624b\u3002\u5b83\u4eec\u4e0d\u505c\u5730\u5728\u4f53\u5185\u5de1\u903b\uff0c\u5bfb\u627e\u5165\u4fb5\u8005\uff0c\u5982\u7ec6\u83cc\u3001\u75c5\u6bd2\uff0c\u4e5f\u5305\u62ec\u4f53\u5185\u5931\u63a7\u7684\u81ea\u8eab\u7ec6\u80de--\u764c\u7ec6\u80de\u3002.<\/p>\n\n\n\n<p>\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0c\u8fd9\u4e9b\u8086\u8650\u7684\u7ec6\u80de\u5f88\u5feb\u5c31\u4f1a\u88ab\u514d\u75ab\u7cfb\u7edf\u7684\u5b88\u62a4\u8005\u53d1\u73b0\uff0c\u5e76\u88ab\u6740\u6b7b\uff0c\u5176\u6b8b\u9ab8\u4e5f\u4f1a\u88ab\u6e05\u9664\u548c\u5206\u89e3\u3002\u8fd9\u79cd\u60c5\u51b5\u6bcf\u5929\u90fd\u5728\u4e0d\u65ad\u53d1\u751f\u3002\u8fd9\u6837\uff0c\u514d\u75ab\u7cfb\u7edf\u5c31\u80fd\u963b\u6b62\u5927\u591a\u6570\u764c\u7ec6\u80de\u6269\u6563\uff0c\u5e76\u53ca\u65f6\u4f7f\u5176\u65e0\u5bb3\u5316\u3002.<\/p>\n\n\n\n<p>\u4f46\u764c\u7ec6\u80de\u5f88\u6709\u521b\u9020\u529b\uff0c\u56e0\u4e3a\u5b83\u4eec\u60f3\u4e0d\u60dc\u4e00\u5207\u4ee3\u4ef7\u751f\u5b58\u4e0b\u53bb\u3002\u56e0\u6b64\uff0c\u5b83\u4eec\u4f1a\u4f2a\u88c5\u81ea\u5df1\uff0c\u6709\u6548\u5730\u8eb2\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u5b88\u62a4\u8005\uff0c\u5e76\u51e0\u4e4e\u4e0d\u53d7\u63a7\u5236\u5730\u7ee7\u7eed\u6269\u6563\u3002\u5b83\u4eec\u4e0d\u4ec5\u8ba9\u4eba\u8ba4\u4e0d\u51fa\u81ea\u5df1\u662f\u654c\u4eba\uff0c\u8fd8\u8ba9\u514d\u75ab\u7cfb\u7edf\u5fd9\u5f97\u4e0d\u53ef\u5f00\u4ea4\uff0c\u4ee5\u81f3\u4e8e\u4e00\u6bb5\u65f6\u95f4\u540e\uff0c\u514d\u75ab\u7cfb\u7edf\u5c31\u4f1a\u7cbe\u75b2\u529b\u7aed\uff0c\u751a\u81f3\u4e0d\u5f97\u4e0d\u4f38\u5c55\u7fc5\u8180--\u5411\u764c\u75c7\u5c48\u670d\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_Immunzelltherapie_macht\"><\/span>\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u7684\u4f5c\u7528<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5728\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u4e2d\uff0c\u514d\u75ab\u7ec6\u80de\u88ab\u4ece\u75c5\u4eba\u4f53\u5185\u53d6\u51fa\uff0c\u914d\u5907\u4e86\u66f4\u597d\u7684\u8bc6\u522b\u6280\u672f\u3001\u66f4\u5f3a\u7684\u6218\u6597\u529b\u6216\u65b0\u7684 \u201e\u76ee\u6807\u5149\u5b66\u201c\uff0c\u7136\u540e\u88ab\u9001\u56de\u4f53\u5185\uff0c\u4ee5\u66f4\u6709\u9488\u5bf9\u6027\u7684\u65b9\u5f0f\u653b\u51fb\u548c\u6d88\u706d\u764c\u75c7\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_Geniale_daran\"><\/span>\u5b83\u7684\u5929\u624d\u4e4b\u5904<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5316\u7597\u539f\u5219\u4e0a\u4f1a\u6740\u6b7b\u4e00\u5207\u5feb\u901f\u5206\u88c2\u7684\u7ec6\u80de\uff08\u4e00\u65b9\u9762\u662f\u764c\u7ec6\u80de\uff0c\u4f46\u65e0\u610f\u4e2d\u4e5f\u4f1a\u6740\u6b7b\u6bdb\u7ec6\u80de\u3001\u80a0\u9053\u7ec6\u80de\u7b49\uff09\uff0c\u800c\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u5219\u4e0d\u540c\uff0c\u5b83\u7684\u76ee\u6807\u662f <strong>\u53ea\u9488\u5bf9\u764c\u7ec6\u80de<\/strong> - \u81f3\u5c11\u5728\u7406\u8bba\u4e0a\u662f\u8fd9\u6837\u3002.<\/p>\n\n\n\n<p>\u7531\u4e8e\u514d\u75ab\u7cfb\u7edf\u4f1a\u8bb0\u4f4f\u5b83\u6240\u8bc6\u522b\u7684\u654c\u4eba\uff0c\u56e0\u6b64\u5982\u679c\u764c\u75c7\u590d\u53d1\uff0c\u5b83\u4f1a\u7acb\u5373\u653b\u51fb\u65b0\u7684\u764c\u7ec6\u80de\u5e76\u5c06\u5176\u6d88\u706d\u3002\u8fd9\u5c31\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u6709\u4e9b\u60a3\u8005\u5728\u8f93\u6ce8\u4e00\u6b21\u540e\u5c31\u80fd\u6c38\u4e45\u6446\u8131\u80bf\u7624\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Die_drei_Typen_%E2%80%93_ganz_einfach\"><\/span>\u4e09\u79cd\u7c7b\u578b--\u975e\u5e38\u7b80\u5355<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>1 CAR-T \u7ec6\u80de\uff1a\u8f6c\u6362<\/strong><br>T\u7ec6\u80de\uff08\u514d\u75ab\u7cfb\u7edf\u7684\u6218\u6597\u529b\u91cf\uff09\u88ab\u63d0\u53d6\u51fa\u6765\uff0c\u5e76\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u4e3a\u5176\u690d\u5165\u4e00\u4e2a\u5168\u65b0\u7684 \u201e\u6293\u624b\u201c--\u4eba\u5de5\u53d7\u4f53\u3002\u5b83\u80fd\u8bc6\u522b\u764c\u7ec6\u80de\u8868\u9762\u7684\u4e00\u4e2a\u975e\u5e38\u7279\u6b8a\u7684\u7279\u5f81\uff0c\u7136\u540e\u76f4\u63a5\u6467\u6bc1\u764c\u7ec6\u80de\u3002.<\/p>\n\n\n\n<p><strong>2 TCR T \u7ec6\u80de\uff1a\u66f4\u597d\u7684\u773c\u955c<\/strong><br>\u4e0e CAR-T \u7c7b\u4f3c\uff0cT \u7ec6\u80de\u4e0d\u662f\u4eba\u5de5\u6293\u53d6\u81c2\uff0c\u800c\u662f\u4e00\u79cd\u7ecf\u8fc7\u6539\u826f\u7684\u5929\u7136\u53d7\u4f53\uff0c\u8fd9\u79cd\u53d7\u4f53\u4e5f\u80fd\u8bc6\u522b\u6df1\u5c42\u6b21\u7684\u7279\u5f81\u3002 <em>\u5185\u4fa7<\/em> \u7684\u764c\u7ec6\u80de\uff0c\u5916\u754c\u53ea\u80fd\u770b\u5230\u5fae\u5c0f\u7684\u788e\u7247\u3002.<\/p>\n\n\n\n<p><strong>\u7b2c 3 \u79cd TIL \u7597\u6cd5\uff1a\u9000\u4f0d\u519b\u4eba<\/strong><br>\u5728\u8fd9\u91cc\uff0c\u63d0\u53d6\u7684 T \u7ec6\u80de\u5df2\u7ecf <em>\u80bf\u7624\u672c\u8eab<\/em> \u5e76\u4e86\u89e3\u4ed6\u3002\u5b83\u4eec\u88ab\u63d0\u53d6\u51fa\u6765\uff0c\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u5927\u91cf\u7e41\u6b96--\u51e0\u4e2a\u7ec6\u80de\u53d8\u6210\u6570\u5341\u4ebf--\u7136\u540e\u88ab\u9001\u56de\u7ecf\u9a8c\u4e30\u5bcc\u7684 \u201e\u8001\u5175 \u201c\u90a3\u91cc\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"T-Zellen_und_ihre_Rolle\"><\/span>T \u7ec6\u80de\u53ca\u5176\u4f5c\u7528<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u4e3b\u8981\u4ee5\u4e24\u79cd\u7ec6\u80de\u7c7b\u578b\u4e3a\u57fa\u7840\uff1a <strong>B \u7ec6\u80de<\/strong> (\u6297\u4f53\u751f\u4ea7\uff09\u548c <strong>T \u7ec6\u80de<\/strong> (\u7ec6\u80de\u514d\u75ab\uff09\u3002T \u7ec6\u80de\u5206\u4e3a\u4e24\u4e2a\u529f\u80fd\u7fa4\uff0c\u4e3b\u8981\u4e0e\u6240\u6709\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u76f8\u5173\uff1a<\/p>\n\n\n\n<p><strong>CD8+ \u7ec6\u80de\u6bd2\u6027 T \u7ec6\u80de (CTL)<\/strong><br>\u901a\u8fc7 T \u7ec6\u80de\u53d7\u4f53 (TCR) \u8bc6\u522b\u611f\u67d3\u7ec6\u80de\u6216\u6076\u6027\u7ec6\u80de\u8868\u9762\u7684\u591a\u80bd-MHC I \u7c7b\u590d\u5408\u7269\uff0c\u5e76\u901a\u8fc7\u7a7f\u5b54\u7d20\/\u7c92\u9176 B \u91ca\u653e\u6216 FasL\/Fas \u76f8\u4e92\u4f5c\u7528\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3002.<\/p>\n\n\n\n<p><strong>CD4+ \u8f85\u52a9 T \u7ec6\u80de<\/strong><br>\u901a\u8fc7\u7ec6\u80de\u56e0\u5b50\u5206\u6ccc\uff08IL-2\u3001IFN-\u03b3\u3001TNF-\u03b1\uff09\u534f\u8c03\u514d\u75ab\u53cd\u5e94\uff0c\u5bf9 CTL \u53cd\u5e94\u7684\u957f\u671f\u6301\u7eed\u6027\u81f3\u5173\u91cd\u8981\u3002.<\/p>\n\n\n\n<p><strong>\u79d1\u5b66\u4f9d\u636e\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>T \u7ec6\u80de\u514d\u75ab\u5b66\u57fa\u7840\u7814\u7a76\uff1a <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK10757\/\" target=\"_blank\" rel=\"noopener\">\u8a79\u97e6\u7684\u514d\u75ab\u751f\u7269\u5b66\uff08NCBI \u4e66\u67b6\uff09<\/a><\/li>\n\n\n\n<li>\u764c\u75c7\u4e2d\u7684 T \u7ec6\u80de\u8870\u7aed\u6982\u8ff0\uff1a <a href=\"https:\/\/www.nature.com\/articles\/nri3862\" target=\"_blank\" rel=\"noopener\">Wherry\u548cKurachi\uff0c\u300a\u81ea\u7136-\u514d\u75ab\u5b66\u8bc4\u8bba\u300b\uff0c2015\u5e74<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tumorimmunologie-Grundprinzip\"><\/span>\u80bf\u7624\u514d\u75ab\u5b66\u7684\u57fa\u672c\u539f\u7406<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u764c\u75c7\u4e0d\u4f1a\u5728\u514d\u75ab\u771f\u7a7a\u4e2d\u53d1\u5c55\u3002\u514d\u75ab <strong>\u764c\u75c7\u514d\u75ab\u7f16\u8f91<\/strong>-\u6982\u5ff5\uff08Dunn\u3001Bruce \u548c Schreiber\uff0c2004 \u5e74\uff09\u63cf\u8ff0\u4e86\u4e09\u4e2a\u9636\u6bb5\uff1a<\/p>\n\n\n\n<p><strong>\u6d88\u9664<\/strong><br>\u514d\u75ab\u7cfb\u7edf\u901a\u8fc7\u80bf\u7624\u76f8\u5173\u6297\u539f\uff08TAA\uff09\u548c\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\uff08TSA\uff09\u8bc6\u522b\u5e76\u6d88\u706d\u8f6c\u5316\u7ec6\u80de\u3002MHC-I \u4ecb\u5bfc\u7684\u7a81\u53d8\u80bd\u53ef\u6fc0\u6d3b CTL\u3002.<\/p>\n\n\n\n<p><strong>\u5e73\u8861<\/strong><br>\u514d\u75ab\u7cfb\u7edf\u4f1a\u4fdd\u6301\u80bf\u7624\u751f\u957f\u7684\u5e73\u8861\uff0c\u4f46\u540c\u65f6\u4e5f\u4f1a\u9009\u62e9\u514d\u75ab\u6297\u6027\u53d8\u4f53\u3002.<\/p>\n\n\n\n<p><strong>\u9003\u79bb<\/strong><br>\u764c\u7ec6\u80de\u4f1a\u901a\u8fc7\u4e0b\u8c03 MHC-I\u3001\u8fc7\u5ea6\u8868\u8fbe\u514d\u75ab\u68c0\u67e5\u70b9\uff08PD-L1\u3001CTLA-4 \u914d\u4f53\uff09\u3001\u5206\u6ccc\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50\uff08TGF-\u03b2\u3001IL-10\uff09\u548c\u62db\u52df\u8c03\u8282\u6027 T \u7ec6\u80de\uff08Tregs\uff09\u6765\u9003\u8131\u3002.<\/p>\n\n\n\n<p><strong>\u79d1\u5b66\u4f9d\u636e\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(02)00272-3\" target=\"_blank\" rel=\"noopener\">Dunn \u7b49\u4eba\uff0c\u300a\u514d\u75ab\u300b\uff0c2002 \u5e74<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(13)00272-X\" target=\"_blank\" rel=\"noopener\">Chen &amp; Mellman\uff0c\u300a\u514d\u75ab\u5b66\u300b2013 \u5e74\u7248--\u764c\u75c7\u514d\u75ab\u5468\u671f<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"CAR-T-Zelltherapie_%E2%80%93_Konstruktion_und_Mechanismus\"><\/span>CAR-T \u7ec6\u80de\u7597\u6cd5--\u8bbe\u8ba1\u4e0e\u673a\u5236<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Molekularer_Aufbau_des_CAR\"><\/span>CAR \u7684\u5206\u5b50\u7ed3\u6784<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\u662f\u4e00\u79cd\u5177\u6709\u56db\u4e2a\u529f\u80fd\u57df\u7684\u5408\u6210\u8de8\u819c\u86cb\u767d\uff1a<\/p>\n\n\n\n<p><strong>1. \u7ec6\u80de\u5916\u7ed3\u5408\u57df<\/strong><br>\u5927\u90e8\u5206\u662f <strong>scFv<\/strong> (\u5355\u514b\u9686\u6297\u4f53\u7684\u5355\u94fe\u53ef\u53d8\u7247\u6bb5\uff09\u3002\u4ee5\u4e0d\u4f9d\u8d56\u4e8e MHC \u7684\u65b9\u5f0f\u76f4\u63a5\u4e0e\u8868\u9762\u6297\u539f\uff08\u5982 B \u7ec6\u80de\u4e0a\u7684 CD19\u3001\u6d46\u7ec6\u80de\u4e0a\u7684 BCMA\uff09\u7ed3\u5408\u3002\u8fd9\u79cd\u4e0e MHC \u65e0\u5173\u7684\u7279\u6027\u662f\u4e0e\u5929\u7136 TCR \u7684\u6839\u672c\u533a\u522b\u3002.<\/p>\n\n\n\n<p><strong>2. \u94f0\u94fe\/\u8fde\u63a5\u533a<\/strong><br>\u7ed3\u5408\u57df\u4e0e\u7ec6\u80de\u819c\u4e4b\u95f4\u7684\u67d4\u6027\u95f4\u9694\uff08\u5982 IgG4-Hinge\u3001CD8\u03b1-Hinge\uff09\u3002\u957f\u5ea6\u548c\u7075\u6d3b\u6027\u5bf9\u7ed3\u5408\u6548\u7387\u6709\u5f88\u5927\u5f71\u54cd\u3002.<\/p>\n\n\n\n<p><strong>3. \u8de8\u819c\u7ed3\u6784\u57df<\/strong><br>\u5c06 CAR \u56fa\u5b9a\u5728 T \u7ec6\u80de\u819c\u4e0a\uff1b\u5f71\u54cd\u4fe1\u53f7\u7684\u7a33\u5b9a\u6027\u3002.<\/p>\n\n\n\n<p><strong>4. \u7ec6\u80de\u5185\u4fe1\u53f7\u7ed3\u6784\u57df<\/strong><br>\u7531\u4e3b\u6fc0\u6d3b\u7ed3\u6784\u57df\uff08CD3\u03b6 \u548c 3 \u4e2a ITAMs\uff09+ \u8f85\u52a9\u523a\u6fc0\u7ed3\u6784\u57df\u7ec4\u6210\u3002\u8f85\u52a9\u523a\u6fc0\u7ed3\u6784\u57df\u5b9a\u4e49\u4e86 <strong>CAR \u4e16\u4ee3\uff1a<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u4e00\u4ee3\u4eba<\/th><th>\u5171\u540c\u523a\u6fc0<\/th><th>\u7279\u70b9<\/th><\/tr><\/thead><tbody><tr><td>\u7b2c 1 \u4ee3<\/td><td>\u4ec5 CD3\u03b6<\/td><td>\u5bff\u547d\u77ed\uff0c\u589e\u6b96\u80fd\u529b\u5f31<\/td><\/tr><tr><td>\u7b2c\u4e8c\u4ee3<\/td><td>CD28 <strong>\u6216<\/strong> 4-1BB (CD137) + CD3\u03b6<\/td><td>\u4eca\u65e5\u6807\u51c6\uff1bKymriah=4-1BB\uff1bYescarta=CD28<\/td><\/tr><tr><td>\u7b2c\u4e09\u4ee3<\/td><td>CD28 <strong>\u548c<\/strong> 4-1BB + CD3\u03b6<\/td><td>\u6fc0\u6d3b\u66f4\u5f3a\uff0cCRS \u98ce\u9669\u589e\u52a0<\/td><\/tr><tr><td>\u7b2c\u56db\u4ee3<\/td><td>\u7b2c\u4e8c\u57fa\u56e0 + \u8f6c\u57fa\u56e0\uff08\u5982 IL-12\u3001IL-15\uff09<\/td><td>\u201e\u88c5\u7532 CAR\u201c\uff0c\u6539\u5584\u80bf\u7624\u5fae\u73af\u5883<\/td><\/tr><tr><td>\u7b2c\u4e94\u4ee3<\/td><td>\u7b2c 2 \u4e2a\u57fa\u56e0 + \u7ec6\u80de\u5185 IL-2R\u03b2 \u7ed3\u6784\u57df<\/td><td>Jagged-CAR\uff1bJAK-STAT \u4fe1\u53f7\u901a\u8def<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>4-1BB \u4e0e CD28 \u534f\u540c\u523a\u6fc0<\/strong><br>4-1BB-CARs\uff08Kymriah\uff09\u663e\u793a\u51fa\u66f4\u597d\u7684\u957f\u671f\u6301\u7eed\u6027\u548c\u66f4\u5c11\u7684\u8870\u7aed\uff08\u66f4\u5c11\u7684T\u7ec6\u80de\u8870\u7aed\uff09\uff0cCD28-CARs\uff08Yescarta\uff09\u663e\u793a\u51fa\u66f4\u5feb\u7684\u521d\u59cb\u6fc0\u6d3b\u548c\u66f4\u9ad8\u7684\u65e9\u671f\u53cd\u5e94\u7387\uff0c\u4f46\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\u5f80\u5f80\u8f83\u77ed\u3002.<\/p>\n\n\n\n<p><strong>\u79d1\u5b66\u4f9d\u636e\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u65bd\u5de5\u6982\u51b5 CAR\uff1a <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMra1706169\" target=\"_blank\" rel=\"noopener\">June &amp; Sadelain, NEJM 2018<\/a><\/li>\n\n\n\n<li>4-1BB \u4e0e CD28 \u7684\u6bd4\u8f83\uff1a <a href=\"https:\/\/www.nature.com\/articles\/s41591-018-0087-0\" target=\"_blank\" rel=\"noopener\">Salter \u7b49\u4eba\uff0c\u300a\u81ea\u7136\u533b\u5b66\u300b\uff0c2018 \u5e74<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Herstellungsprozess_Autolog\"><\/span>\u5236\u9020\u5de5\u827a\uff08\u81ea\u4f53\uff09<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><strong>\u767d\u7ec6\u80de\u5206\u79bb<\/strong><br>\u5728 3-5 \u5c0f\u65f6\u5185\u901a\u8fc7\u7ec6\u80de\u5206\u79bb\u4ece\u60a3\u8005\u8840\u6db2\u4e2d\u91c7\u96c6\u5355\u6838\u8840\u7ec6\u80de\u3002.<\/p>\n\n\n\n<p><strong>T \u7ec6\u80de\u6fc0\u6d3b<\/strong><br>\u7528\u6297-CD3\/\u6297-CD28 \u6297\u4f53\u5305\u88ab\u73e0\u6216\u91cd\u7ec4\u914d\u4f53\u8fdb\u884c\u4f53\u5916\u523a\u6fc0\uff1b\u52a0\u5165 IL-2 \u548c IL-7\/IL-15 \u4ee5\u4fc3\u8fdb\u589e\u6b96\u3002.<\/p>\n\n\n\n<p><strong>\u57fa\u56e0\u8f6c\u79fb<\/strong><br>\u91c7\u7528 CAR \u57fa\u56e0\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6162\u75c5\u6bd2\u8f7d\u4f53<\/strong> (Kymriah, Breyanzi\uff09\uff1a\u7a33\u5b9a\u5730\u6574\u5408\u5230\u5bbf\u4e3b\u57fa\u56e0\u7ec4\u4e2d\uff1b\u957f\u671f\u8868\u8fbe<\/li>\n\n\n\n<li><strong>\u4f3d\u9a6c\u9006\u8f6c\u5f55\u75c5\u6bd2\u8f7d\u4f53<\/strong> (Yescarta, Tecartus\uff09\uff1a\u7c7b\u4f3c\uff0c\u4f46\u63d2\u5165\u8bf1\u53d8\u98ce\u9669\u8f83\u9ad8<\/li>\n\n\n\n<li><strong>\u8f6c\u5ea7\u5b50\u7cfb\u7edf\/mRNA<\/strong> (\u5b9e\u9a8c\uff09\uff1a\u975e\u4e00\u4f53\u5316\u66ff\u4ee3\u54c1<\/li>\n<\/ul>\n\n\n\n<p><strong>\u6269\u5efa<\/strong><br>\u8f6c\u5bfc\u7ec6\u80de\u7ecf\u8fc7 7-14 \u5929\u7684\u7e41\u6b96\uff0c\u4e00\u822c\u8fbe\u5230 10\u2078-10\ud841\udf99 \u4e2a\u3002.<\/p>\n\n\n\n<p><strong>\u8d28\u91cf\u63a7\u5236<\/strong><br>\u6d4b\u8bd5 CAR \u8f6c\u5bfc\u6548\u7387\u3001\u65e0\u83cc\u6027\u3001\u6b8b\u7559\u6210\u5206\u3001T \u7ec6\u80de\u8868\u578b\u3001\u6548\u529b\u6d4b\u8bd5\u3002.<\/p>\n\n\n\n<p><strong>\u4f4e\u6e29\u4fdd\u5b58\u548c\u8fd0\u8f93<\/strong><br>\u5230\u6cbb\u7597\u4e2d\u5fc3\u3002.<\/p>\n\n\n\n<p><strong>\u6dcb\u5df4\u6d88\u8017<\/strong><br>\u60a3\u8005\u5728 CAR-T \u8f93\u6ce8\u524d 2-7 \u5929\u63a5\u53d7\u5316\u7597\uff08\u901a\u5e38\u662f\u6c1f\u8fbe\u62c9\u6ee8+\u73af\u78f7\u9170\u80fa\uff09\uff0c\u4ee5\u51cf\u5c11\u673a\u4f53\u81ea\u8eab\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u521b\u9020 \u201e\u7a7a\u95f4\u201c\uff08\u6dcb\u5df4\u6d88\u8017\u8c03\u7406\uff09\u3002\u8fd9\u4e00\u6b65\u9aa4\u53ef\u901a\u8fc7IL-7\/IL-15\u4fe1\u53f7\u7684\u5e73\u8861\u4f5c\u7528\uff0c\u5927\u91cf\u589e\u52a0CAR-T\u7ec6\u80de\u7684\u589e\u6b96\u548c\u6301\u4e45\u6027\u3002.<\/p>\n\n\n\n<p><strong>\u8f93\u6db2<\/strong><br>\u5355\u6b21\u9759\u8109\u6ce8\u5c04 CAR-T \u7ec6\u80de\u3002.<\/p>\n\n\n\n<p><strong>\u80cc\u540e\u7684\u79d1\u5b66<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6dcb\u5df4\u6d88\u8017\u673a\u5236 <a href=\"https:\/\/www.nature.com\/articles\/nm1263\" target=\"_blank\" rel=\"noopener\">Gattinoni \u7b49\u4eba\uff0c\u300a\u81ea\u7136\u533b\u5b66\u300b\uff0c2005 \u5e74<\/a><\/li>\n\n\n\n<li>\u751f\u4ea7\u6982\u51b5 <a href=\"https:\/\/www.cell.com\/molecular-therapy-family\/molecular-therapy\/fulltext\/S1525-0016(16)45462-1\" target=\"_blank\" rel=\"noopener\">\u83b1\u6587\u7b49\u4eba\uff0c\u300a\u5206\u5b50\u6cbb\u7597\u300b\uff0c2017 \u5e74<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wirkmechanismus_Effektorphase\"><\/span>\u4f5c\u7528\u673a\u5236\u548c\u6548\u5e94\u9636\u6bb5<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u8f93\u6ce8\u540e\uff0cCAR-T \u7ec6\u80de\u80fd\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u4e0a\u7684\u76ee\u6807\u6297\u539f\uff0c\u4ece\u800c\u5f62\u6210\u514d\u75ab\u7a81\u89e6\uff1aCAR \u4e0e\u6297\u539f\u7ed3\u5408\u2192CD3\u03b6-ITAM \u78f7\u9178\u5316\u2192ZAP-70\/Lck \u6fc0\u9176\u7ea7\u8054\u2192NF-\u03baB\u3001NFAT\u3001AP-1 \u6fc0\u6d3b\u2192\u7a7f\u5b54\u7d20\/\u9176 B \u91ca\u653e\uff08\u76f4\u63a5\u7ec6\u80de\u6eb6\u89e3\uff09+ IFN-\u03b3\u3001TNF-\u03b1\uff08\u7ec6\u80de\u56e0\u5b50\u5206\u6ccc\uff09\u3002.<\/p>\n\n\n\n<p>\u5e76\u884c <strong>\u6fc0\u6d3b\u65c1\u89c2\u8005<\/strong> - \u91ca\u653e\u7684\u7ec6\u80de\u56e0\u5b50\u4f1a\u6fc0\u6d3b\u5176\u4ed6\u5185\u6e90\u6027\u514d\u75ab\u7ec6\u80de\uff0c\u5e76\u53ef\u80fd\u5bfc\u81f4\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u3002.<\/p>\n\n\n\n<p><strong>\u79d1\u5b66<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>CAR-T \u7684\u4f5c\u7528\u673a\u5236\uff1a <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aam8871\" target=\"_blank\" rel=\"noopener\">\u6797\u548c\u541b\uff0c\u300a\u79d1\u5b66\u300b2017 \u5e74<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TCR-T-Zelltherapie_Die_entscheidenden_Unterschiede\"><\/span>TCR-T \u7ec6\u80de\u7597\u6cd5\uff1a\u4e3b\u8981\u533a\u522b<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Warum_TCR_und_nicht_CAR_fur_intrazellulare_Antigene\"><\/span>\u7ec6\u80de\u5185\u6297\u539f\u4e3a\u4ec0\u4e48\u662f TCR \u800c\u4e0d\u662f CAR\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>CAR \u53d7\u4f53\u53ea\u80fd\u8bc6\u522b <strong>\u8868\u9762\u86cb\u767d\u8d28<\/strong>. .\u7136\u800c\uff0c\u7531\u4e8e\u5927\u591a\u6570\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\u90fd\u5728\u7ec6\u80de\u5185\u5b9a\u4f4d\uff08\u8f6c\u5f55\u56e0\u5b50\u3001\u4ee3\u8c22\u9176\u3001\u764c\u75c7\u777e\u4e38\u6297\u539f\uff0c\u5982 PRAME\u3001MAGE-A4\uff09\uff0cCAR-T \u5bf9\u8fd9\u4e9b\u9776\u70b9\u89c6\u800c\u4e0d\u89c1\u3002.<\/p>\n\n\n\n<p>\u5929\u7136 TCR \u5177\u6709\u8bc6\u522b\u7ec6\u80de\u5185\u86cb\u767d\u8d28\u7684\u80fd\u529b\uff0c\u56e0\u4e3a\u7ec6\u80de\u5185\u86cb\u767d\u8d28\u4f1a\u4e0d\u65ad\u88ab <strong>\u86cb\u767d\u9176\u4f53<\/strong> \u964d\u89e3\u4e3a ~8-11 \u4e2a\u6c28\u57fa\u9178\u957f\u7684\u80bd\u3002\u8fd9\u4e9b\u80bd\u5728\u5185\u8d28\u7f51\u4e2d\u964d\u89e3\u4e3a <strong>MHC I \u7c7b\u5206\u5b50\uff08\u4eba\u7c7b\u7684 HLA\uff09<\/strong> \u5e76\u8fd0\u9001\u5230\u7ec6\u80de\u8868\u9762\u3002\u5728\u90a3\u91cc\uff0c\u5b83\u4eec\u4f1a\u88ab\u03b1\u03b2-TCR\u7ed3\u5408\uff0c\u8fd9\u79cd\u673a\u5236\u5728\u6240\u6709\u6709\u6838\u4f53\u7ec6\u80de\u4e0a\u90fd\u5f88\u6d3b\u8dc3\u3002.<\/p>\n\n\n\n<p><strong>TCR \u7597\u6cd5\u7684\u6280\u672f\u6311\u6218<\/strong> \u662f\u5fc5\u8981\u7684 HLA \u9650\u5236\uff1a\u5929\u7136\u9ad8\u4eb2\u548c\u529b TCR \u53ea\u80fd\u5728\u7279\u5b9a HLA \u7b49\u4f4d\u57fa\u56e0\uff08\u5982 HLA-A*02:01\uff0c\u5728\u9ad8\u52a0\u7d22\u4eba\u7fa4\u4e2d\u7ea6\u6709 40-50 %\uff09\u7684\u80cc\u666f\u4e0b\u8bc6\u522b\u7279\u5b9a\u80bd\u3002\u8fd9\u610f\u5473\u7740\u60a3\u8005\u5fc5\u987b\u540c\u65f6\u5177\u6709 HLA \u76f8\u5bb9\u6027\u548c\u76ee\u6807\u6297\u539f\u7684\u80bf\u7624\u9633\u6027\u3002.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Struktur_des_therapeutischen_TCR\"><\/span>\u6cbb\u7597\u6027 TCR \u7684\u7ed3\u6784<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u6cbb\u7597\u6027 TCR \u591a\u4e3a <strong>\u03b1\u03b2-TCR \u5f02\u4e8c\u805a\u4f53<\/strong>, \u5176\u4e2d\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u901a\u8fc7\u566c\u83cc\u4f53\u5c55\u793a\u6216\u5c0f\u9f20\u4eba\u6e90\u5316\u5f00\u53d1\uff0c\u5177\u6709\u6781\u9ad8\u7684\u4eb2\u548c\u529b\uff08KD \u5728 pM \u8303\u56f4\u5185\uff09\u3002\u5929\u7136 TCR \u53ea\u6709\u4e2d\u7b49\u4eb2\u548c\u529b\uff08\u03bcM\uff09\uff0c\u56e0\u4e3a\u8fc7\u9ad8\u7684\u4eb2\u548c\u529b\u4f1a\u5bfc\u81f4\u81ea\u8eab\u514d\u75ab<\/li>\n\n\n\n<li>\u901a\u8fc7\u5c0f\u9f20\u66ff\u6362\u6216\u4e8c\u786b\u952e\u7a33\u5b9a\uff0c\u9632\u6b62\u4e0e\u5185\u6e90\u6027 TCR \u94fe\u610f\u5916\u914d\u5bf9<\/li>\n\n\n\n<li>\u901a\u8fc7\u6162\u75c5\u6bd2\u8f6c\u5bfc\u5c06\u5176\u5bfc\u5165\u60a3\u8005\u81ea\u8eab\u7684 T \u7ec6\u80de\u4e2d<\/li>\n<\/ul>\n\n\n\n<p><strong>\u79d1\u5b66<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>TCR \u4eb2\u548c\u5de5\u7a0b\uff1a <a href=\"https:\/\/www.jimmunol.org\/content\/180\/9\/6116\" target=\"_blank\" rel=\"noopener\">\u7f57\u5bbe\u65af\u7b49\u4eba\uff0c\u300a\u514d\u75ab\u5b66\u6742\u5fd7\u300b\uff0c2008 \u5e74<\/a><\/li>\n\n\n\n<li>TCR-T \u673a\u5236\u6982\u8ff0\uff1a <a href=\"https:\/\/aacrjournals.org\/cancerimmunolres\/article\/7\/8\/1236\/469286\" target=\"_blank\" rel=\"noopener\">Dangaj \u7b49\u4eba\uff0c\u300a\u764c\u75c7\u514d\u75ab\u5b66\u7814\u7a76\u300b\uff0c2019 \u5e74<\/a><\/li>\n\n\n\n<li>\u7528\u4e8e Tecelra \u7684 MAGE-A4 TCR \u57fa\u5730\uff1a <a href=\"https:\/\/aacrjournals.org\/clincancerres\/article\/25\/24\/7537\/82286\" target=\"_blank\" rel=\"noopener\">Kageyama \u7b49\u4eba\uff0c\u300a\u4e34\u5e8a\u764c\u75c7\u7814\u7a76\u300b\uff0c2019 \u5e74<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TIL-Therapie_%E2%80%93_Prinzip_der_naturlichen_Tumorerkennung\"><\/span>TIL\u7597\u6cd5--\u81ea\u7136\u80bf\u7624\u68c0\u6d4b\u539f\u7406<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Biologische_Grundlage\"><\/span>\u751f\u7269\u5b66\u57fa\u7840<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u80bf\u7624\u4f1a\u88ab\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\uff0c\u8fd9\u4e9b\u514d\u75ab\u7ec6\u80de\u5305\u62ec <strong>\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TIL\uff09<\/strong>. .\u8fd9\u4e9b T \u7ec6\u80de\u5df2\u7ecf\u8bc6\u522b\u4e86\u80bf\u7624\uff0c\u4f46\u7531\u4e8e\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u5b83\u4eec\u5f80\u5f80\u5df2\u7ecf\u8870\u7aed\u3001\u5931\u53bb\u6d3b\u6027\u6216\u6570\u91cf\u8fc7\u5c11\u3002\u5728\u8bb8\u591a\u7c7b\u578b\u7684\u764c\u75c7\u4e2d\uff0c\u80bf\u7624\u4e2d\u7684 TIL \u5bc6\u5ea6\u8d8a\u9ad8\uff0c\u9884\u540e\u8d8a\u597d\u3002.<\/p>\n\n\n\n<p>TIL\u7597\u6cd5\u7684\u7406\u5ff5\uff08\u7531\u8d1d\u585e\u65af\u8fbeNCI\u7684\u53f2\u8482\u6587-\u7f57\u68ee\u4f2f\u683c\u4e8e20\u4e16\u7eaa80\u5e74\u4ee3\u63d0\u51fa\uff09\uff1a\u5229\u7528\u8fd9\u4e9b\u5df2\u7ecf\u5177\u6709\u80bf\u7624\u7279\u5f02\u6027\u7684 T \u7ec6\u80de\uff0c\u5c06\u5b83\u4eec\u4ece\u514d\u75ab\u6291\u5236\u73af\u5883\u4e2d\u89e3\u653e\u51fa\u6765\uff0c\u5728\u4f53\u5916\u5927\u91cf\u6fc0\u6d3b\u548c\u7e41\u6b96\u5b83\u4eec\uff0c\u5e76\u5c06\u5b83\u4eec\u5927\u91cf\u9001\u56de\u4f53\u5185\uff0c\u5c3d\u7ba1\u5b83\u4eec\u6709\u8870\u7aed\u7684\u8d8b\u52bf\uff0c\u4f46\u4ecd\u80fd\u53d1\u6325\u6cbb\u7597\u6548\u679c\u3002.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Herstellungsprozess_Lifileucel\"><\/span>\u751f\u4ea7\u5de5\u827a\uff08Lifileucel\uff09<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><strong>\u80bf\u7624\u5207\u9664\u672f<\/strong><br>\u624b\u672f\u5207\u9664\u81f3\u5c11 1.5 \u7acb\u65b9\u5398\u7c73\u7684\u80bf\u7624\u7ec4\u7ec7\uff0c\u5e76\u7acb\u5373\u5c06\u5176\u52a0\u5de5\u6210 <a href=\"https:\/\/www.iovance.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Iovance \u751f\u7269\u6cbb\u7597\u516c\u53f8.<\/a> \u53d1\u9001\u3002.<\/p>\n\n\n\n<p><strong>\u521d\u59cb\u6269\u5c55\uff08\u7ea6 11 \u5929\uff09<\/strong><br>\u80bf\u7624\u7ecf\u673a\u68b0\u548c\u9176\u89e3\u79bb\uff1bTIL \u5728 IL-2 \u2192 \u9884\u5feb\u901f\u6269\u589e\u65b9\u6848\uff08Pre-REP\uff09\u5b58\u5728\u4e0b\u57f9\u517b\u3002.<\/p>\n\n\n\n<p><strong>\u5feb\u901f\u6269\u5c55\uff08\u7ea6 11 \u5929\uff09<\/strong><br>\u7528\u6297 CD3 \u6297\u4f53\uff08OKT3\uff09\u3001\u8f90\u7167\u8fc7\u7684\u5f02\u4f53 PBMC\uff08\u5145\u5f53\u6297\u539f\u9012\u5448\u7ec6\u80de\uff09\u548c IL-2 \u5904\u7406 TIL\uff0c\u4f7f\u5176\u4e0e\u6297 CD3 \u6297\u4f53\uff08OKT3\uff09\u3001\u8f90\u7167\u8fc7\u7684\u5f02\u4f53 PBMC\uff08\u5145\u5f53\u6297\u539f\u9012\u5448\u7ec6\u80de\uff09\u548c IL-2 \u7ed3\u5408\u5728\u4e00\u8d77\u3002 <strong>&gt;7.5 \u00d7 10\u2079 \u7ec6\u80de<\/strong> \u6269\u5927\uff08\u4ece\u51e0\u767e\u4e07\u5230\u51e0\u5341\u4ebf\uff09\u3002.<\/p>\n\n\n\n<p><strong>\u6dcb\u5df4\u6d88\u8017\u548c\u8f93\u6ce8<\/strong><br>\u4e0e CAR-T \u76f8\u540c\uff1aFlu\/Cy \u8c03\u7406\uff0c\u7136\u540e\u5355\u6b21\u8f93\u6ce8 TIL\uff0c\u63a5\u7740\u65bd\u7528 IL-2 \u8fdb\u4e00\u6b65\u4f53\u5185\u6269\u589e\u3002.<\/p>\n\n\n\n<p><strong>\u65f6\u95f4\u6846\u67b6<\/strong><br>\u751f\u4ea7\u7ea6 22 \u5929\uff1b\u4ece\u80bf\u7624\u5207\u9664\u5230\u8f93\u6db2\u5171\u7ea6 6-7 \u5468\u3002.<\/p>\n\n\n\n<p><strong>\u79d1\u5b66<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7f57\u68ee\u4f2f\u683c\u7684\u5f00\u521b\u6027\u5de5\u4f5c\uff1a <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJM198812223192529\" target=\"_blank\" rel=\"noopener\">\u7f57\u68ee\u4f2f\u683c\u7b49\u4eba\uff0c1988 \u5e74 NEJM<\/a><\/li>\n\n\n\n<li>Lifileucel 2 \u671f\u5173\u952e\u6027\u7814\u7a76\uff08C-144-01\uff09\uff1a <a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.21.02179\" target=\"_blank\" rel=\"noopener\">\u5207\u65af\u5c3c\u7b49\u4eba\uff0cJCO 2022<\/a><\/li>\n\n\n\n<li>\u968f\u8bbf 5 \u5e74\uff1a <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40699950\/\" target=\"_blank\" rel=\"noopener\">2024 \u5e74\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u6458\u8981<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Herausforderungen_%E2%80%93_aktuelle_Forschungsansatze\"><\/span>\u6311\u6218--\u5f53\u524d\u7684\u7814\u7a76\u65b9\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Antigen-Escape\"><\/span>\u6297\u539f\u9003\u9038<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><strong>\u95ee\u9898\u5b9a\u4e49<\/strong><br>\u80bf\u7624\u7ec6\u80de\u53ef\u4e0b\u8c03\u6216\u5931\u53bb\u9776\u6297\u539f\u7684\u8868\u8fbe\u3002\u5728 CD19-CAR-T \u4e2d\uff0c30-40 % \u7684\u75c5\u4f8b\u4f1a\u51fa\u73b0 CD19 \u9634\u6027\u590d\u53d1\u3002.<\/p>\n\n\n\n<p><strong>\u89e3\u51b3\u65b9\u6848<\/strong><br>\u53cc\u91cd\u9776\u5411\u7b56\u7565\uff08CD19+CD22\u3001BCMA+CD38\uff09\u3001\u4e32\u8054 CAR\u3001\u903b\u8f91\u95e8 CAR\uff08AND \u95e8\uff1a\u9700\u8981\u4e24\u79cd\u6297\u539f\uff1bNOT \u95e8\uff1a\u53ea\u6740\u6b7b\u6ca1\u6709\u4fdd\u62a4\u6027\u6297\u539f\u7684\u7ec6\u80de\uff09\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/nm.4164\" target=\"_blank\" rel=\"noopener\">Ruella \u7b49\u4eba\uff0c\u300a\u81ea\u7136\u533b\u5b66\u300b\uff0c2016 \u5e74\uff08CD19-Escape\uff09<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"T-Zell-Erschopfung_Exhaustion\"><\/span>T \u7ec6\u80de\u8870\u7aed\uff08\u8870\u7aed\uff09<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><strong>\u95ee\u9898\u5b9a\u4e49<\/strong><br>\u80bf\u7624\u7ec6\u80de\u53ef\u4e0b\u8c03\u6216\u5931\u53bb\u9776\u6297\u539f\u7684\u8868\u8fbe\u3002\u5728 CD19-CAR-T \u4e2d\uff0c30-40 % \u7684\u75c5\u4f8b\u4f1a\u51fa\u73b0 CD19 \u9634\u6027\u590d\u53d1\u3002.<\/p>\n\n\n\n<p>\u6162\u6027\u6297\u539f\u66b4\u9732\u2192\u8870\u7aed\u6807\u5fd7\u7269\uff08PD-1\u3001TIM-3\u3001LAG-3\u3001TOX \u8f6c\u5f55\u56e0\u5b50\uff09\u8868\u8fbe\u2192\u529f\u80fd\u4e27\u5931\u3002.<\/p>\n\n\n\n<p><strong>\u89e3\u51b3\u65b9\u6848<\/strong> \u4e0e\u68c0\u67e5\u70b9\u6291\u5236\u5242\u76f8\u7ed3\u5408\u3001\u901a\u8fc7 TET2 \u6572\u9664\u8fdb\u884c\u8868\u89c2\u9057\u4f20\u91cd\u7f16\u7a0b\u3001\u5185\u7f6e\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u4e0b\u4e00\u4ee3 CAR \u8bbe\u8ba1\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1546-z\" target=\"_blank\" rel=\"noopener\">Chen \u7b49\u4eba\uff0c\u300a\u81ea\u7136\u300b2019\uff08TET2 \u57fa\u56e0\u6572\u9664\uff09<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tumormikroumgebung_TME\"><\/span>\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><strong>\u95ee\u9898\u5b9a\u4e49<\/strong><br>\u80bf\u7624\u7ec6\u80de\u53ef\u4e0b\u8c03\u6216\u5931\u53bb\u9776\u6297\u539f\u7684\u8868\u8fbe\u3002\u5728 CD19-CAR-T \u4e2d\uff0c30-40 % \u7684\u75c5\u4f8b\u4f1a\u51fa\u73b0 CD19 \u9634\u6027\u590d\u53d1\u3002.<\/p>\n\n\n\n<p>\u5b9e\u4f53\u7624\u7684\u5fae\u73af\u5883\u6076\u52a3\uff1a\u7f3a\u6c27\u3001\u8461\u8404\u7cd6\u7f3a\u4e4f\u3001\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50\uff08TGF-\u03b2\u3001IL-10\uff09\u3001Tregs\u3001MDSCs\u3002.<\/p>\n\n\n\n<p><strong>\u89e3\u51b3\u65b9\u6848<\/strong><br>\u5206\u6cccIL-12\/IL-15\/IL-18\u7684\u94e0\u88c5CAR\u3001\u6297PD-1\u7684CAR\u3001\u4e0e\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u7ed3\u5408\u3001\u5c40\u90e8\u7624\u5185\u6ce8\u5c04\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41598-017-10259-0\" target=\"_blank\" rel=\"noopener\">Yeku \u7b49\u4eba\uff0c\u300a\u79d1\u5b66\u62a5\u544a 2017\u300b\uff08\u88c5\u7532 CAR\uff09<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zytokinsturm_CRS_ICANS\"><\/span>\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\uff08CRS\uff09\u548c ICANS<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><strong>\u95ee\u9898\u5b9a\u4e49<\/strong><br>CRS \u662f\u7531\u6d3b\u5316\u7684 CAR-T \u548c\u5de8\u566c\u7ec6\u80de\u5927\u91cf\u91ca\u653e\u7ec6\u80de\u56e0\u5b50\uff08IL-6\u3001IFN-\u03b3\u3001IL-1\u03b2\uff09\u5f15\u8d77\u7684\u3002\u4e25\u91cd\u7684 CRS\uff083-4 \u7ea7\uff09\u9700\u8981\u5f3a\u5316\u6cbb\u7597\u3002ICANS\uff08\u795e\u7ecf\u6bd2\u6027\uff09\u662f\u5185\u76ae\u6fc0\u6d3b\u548c\u8840\u8111\u5c4f\u969c\u529f\u80fd\u969c\u788d\u7684\u7ed3\u679c\u3002.<\/p>\n\n\n\n<p><strong>\u7ba1\u7406\u5c42<\/strong><br>Tocilizumab\uff08IL-6R \u963b\u65ad\u5242\uff09\u3001\u76ae\u8d28\u7c7b\u56fa\u9187\u3001anakinra\uff08IL-1 \u963b\u65ad\u5242\uff09\uff1b\u65e9\u671f\u5e72\u9884\u53ef\u63d0\u9ad8\u7597\u6548\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4116524\/\" target=\"_blank\" rel=\"noopener\">Lee \u7b49\u4eba\uff0c\u300a2014 \u5e74\u8840\u6db2\u5b66\u300b--CRS \u5206\u7ea7\u7cfb\u7edf<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/nrneurol.2018.138\" target=\"_blank\" rel=\"noopener\">Neelapu \u7b49\u4eba\uff0cNature Reviews Neurology 2018 - ICANS<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Allogene_%E2%80%9EOff-the-shelf%E2%80%9C-Therapien\"><\/span>\u5f02\u4f53 \u201e\u73b0\u6210 \u201c\u7597\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><strong>\u95ee\u9898\u5b9a\u4e49<\/strong><br>\u80bf\u7624\u7ec6\u80de\u53ef\u4e0b\u8c03\u6216\u5931\u53bb\u9776\u6297\u539f\u7684\u8868\u8fbe\u3002\u5728 CD19-CAR-T \u4e2d\uff0c30-40 % \u7684\u75c5\u4f8b\u4f1a\u51fa\u73b0 CD19 \u9634\u6027\u590d\u53d1\u3002.<\/p>\n\n\n\n<p>\u81ea\u4f53\u751f\u4ea7\u9700\u8981 3-6 \u5468\u65f6\u95f4\uff0c\u4ef7\u683c\u6602\u8d35\uff08400,000-600,000 \u6b27\u5143\uff09\u3002.<\/p>\n\n\n\n<p><strong>\u89e3\u51b3\u65b9\u6848<\/strong><br>\u6765\u81ea\u5065\u5eb7\u4f9b\u4f53\u7684\u5f02\u4f53 CAR-T\uff0c\u901a\u8fc7 CRISPR \u57fa\u56e0\u6572\u9664\u5185\u6e90\u6027 TCR\uff08\u9884\u9632 GvHD\uff09\u548c HLA \u6210\u5206\uff08\u9884\u9632\u6392\u65a5\u53cd\u5e94\uff09\u3002.<\/p>\n\n\n\n<p><strong>\u5f53\u524d\u6570\u636e<\/strong><br>CTX112\uff08CRISPR-\u5f02\u57fa\u56e0 CD19-CAR-T\uff09\u5728 CLL \u7b2c\u4e00\u9636\u6bb5\u663e\u793a\u51fa\u9996\u6b21\u5b8c\u5168\u7f13\u89e3\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abb4845\" target=\"_blank\" rel=\"noopener\">Stadtmauer \u7b49\u4eba\uff0c\u300a\u79d1\u5b66 2020\u300b--CRISPR CAR-T \u7b2c\u4e00\u9636\u6bb5<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"27_Quantitative_Wirksamkeitsdaten_im_Uberblick\"><\/span>2.7 \u91cf\u5316\u6210\u6548\u6570\u636e\u6982\u89c8<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u6cbb\u7597<\/th><th>\u8bf4\u660e<\/th><th>ORR<\/th><th>CR \u6bd4\u7387<\/th><th>\u4e2d\u4f4d OS<\/th><th>\u8d44\u6599\u6765\u6e90<\/th><\/tr><\/thead><tbody><tr><td>Tisagenlecleucel<\/td><td>B-ALL \u513f\u79d1<\/td><td>81 %<\/td><td>60 %<\/td><td>NR\uff0812 \u4e2a\u6708\u65f6\u4e3a 63 %\uff09<\/td><td>NEJM 2018<\/td><\/tr><tr><td>Axicabtagene-cel<\/td><td>DLBCL \u4e09\u7ebf<\/td><td>83 %<\/td><td>58 %<\/td><td>NR\uff0812 \u4e2a\u6708\u65f6\u4e3a 74 %\uff09<\/td><td>NEJM 2017<\/td><\/tr><tr><td>Ciltacabtagene-cel<\/td><td>\u591a\u3002\u9aa8\u9ad3\u7624<\/td><td>98 %<\/td><td>78 %<\/td><td>NR\uff0812 \u4e2a\u6708\u65f6 &gt;80 %\uff09<\/td><td>\u67f3\u53f6\u5200 2021<\/td><\/tr><tr><td>Lifileucel<\/td><td>\u9ed1\u8272\u7d20\u7624<\/td><td>31,4 %<\/td><td>7,5 %<\/td><td>\u65e0\uff0824 \u4e2a\u6708\u65f6\u6709 49 \u4e2a %\uff09<\/td><td>JCO 2022<\/td><\/tr><tr><td>Afamitresgene-cel<\/td><td>\u6ed1\u819c\u8089\u7624<\/td><td>43 %<\/td><td>4 %<\/td><td>16.4 \u4e2a\u6708<\/td><td>\u67f3\u53f6\u5200 2024<\/td><\/tr><tr><td>Tebentafusp<\/td><td>\u773c\u8272\u7d20\u5c42\u9ed1\u8272\u7d20\u7624<\/td><td>9 % (ORR)<\/td><td>&lt;1 %<\/td><td>21.7 \u4e2a\u6708<\/td><td>NEJM 2021<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><em>(NR = \u672a\u8fbe\u5230\uff1bOS* \u5c1a\u672a\u8fbe\u5230)<\/em><\/p>\n\n\n\n<p>*<em>\u64cd\u4f5c\u7cfb\u7edf<\/em> (<em>\u603b\u751f\u5b58\u7387<\/em>\u00a0) - \u4f8b\u5982\u201e<em>OS \u4e2d\u4f4d\u6570 21.7<\/em>\u201e\u4e00\u534a\u60a3\u8005\u5728 21.7 \u4e2a\u6708\u540e\u6b7b\u4ea1\uff0c\u53e6\u4e00\u534a\u60a3\u8005\u4ecd\u7136\u5b58\u6d3b<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Weiterfuhrende_Literatur_Ressourcen\"><\/span>\u66f4\u591a\u9605\u8bfb\u548c\u8d44\u6e90<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>\u8bc4\u8bba<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aar6711\" target=\"_blank\" rel=\"noopener\">June \u7b49\u4eba\uff0c\u300a\u79d1\u5b66\u300b\u6742\u5fd7\uff0c2018 \u5e74 - CAR-T \u7597\u6cd5\u6982\u8ff0<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00428-019-02571-3\" target=\"_blank\" rel=\"noopener\">Rohaan\u7b49\u4eba\uff0cVirchows Arch 2019 - TIL\u7597\u6cd5\u7efc\u8ff0<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1840-9\" target=\"_blank\" rel=\"noopener\">Stadtmauer \u7b49\u4eba\uff0c\u300a\u81ea\u7136-2020\u300b--\u5f02\u4f53 TCR\/CAR-T<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>\u6307\u5357\u4e0e\u6570\u636e\u5e93\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/clinicaltrials.gov\/search?term=CAR-T+OR+TIL+OR+TCR-T&amp;recency=5\" target=\"_blank\" rel=\"noopener\">ClinicalTrials.gov - \u6240\u6709\u6b63\u5728\u8fdb\u884c\u7684\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u8bd5\u9a8c<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.cancer.gov\/about-cancer\/treatment\/types\/immunotherapy\/t-cell-transfer-therapy\" target=\"_blank\" rel=\"noopener\">NCI - \u514d\u75ab\u7597\u6cd5\u6982\u8ff0<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.dgho.de\/informationen\/stellungnahmen\/gute-wissenschaftliche-praxis\/car-t-zellen\" target=\"_blank\" rel=\"noopener\">\u5fb7\u56fd\u8840\u6db2\u5b66\u4f1a (DGHO) - CAR-T \u7597\u6cd5<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>\u65b9\u4fbf\u60a3\u8005\u7684\u8d44\u6e90\uff08\u5fb7\u8bed\uff09\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.krebshilfe.de\/informieren\/ueber-krebs\/therapie\/immuntherapie\/\" target=\"_blank\" rel=\"noopener\">Krebshilfe Deutschland - \u514d\u75ab\u7597\u6cd5\u8be6\u89e3<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.kitz-heidelberg.de\/forschungsprogramme\/zell-und-gentherapie\/\" target=\"_blank\" rel=\"noopener\">\u6d77\u5fb7\u5821 KiTZ - \u60a3\u8005\u4e0e\u514d\u75ab\u7597\u6cd5<\/a><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><em>\u5728\u4e0d\u5230\u5341\u5e74\u7684\u65f6\u95f4\u91cc\uff0c\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u5df2\u7ecf\u4ece\u4e00\u4e2a\u5b9e\u9a8c\u6027\u6982\u5ff5\u98de\u8dc3\u6210\u4e3a\u4e00\u79cd\u6807\u51c6\u7684\u4e34\u5e8a\u7597\u6cd5--\u83b7\u6279\u4ea7\u54c1\u548c\u9002\u5e94\u75c7\u7684\u6570\u91cf\u6301\u7eed\u5feb\u901f\u589e\u957f\u3002\u5bf9\u4e8e\u7b26\u5408\u6761\u4ef6\u7684\u60a3\u8005\u6765\u8bf4\uff0c\u8fd9\u53ef\u80fd\u662f\u552f\u4e00\u53ef\u80fd\u6cbb\u6108\u75be\u75c5\u7684\u9009\u62e9\u3002.<\/em><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Weltweit_zugelassene_Immunzelltherapien\"><\/span>\u5168\u7403\u8ba4\u53ef\u7684\u514d\u75ab\u7ec6\u80de\u7597\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u72b6\u6001 02.2026<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Einleitung_Die_drei_grosen_Klassen\"><\/span>\u5bfc\u8a00\uff1a\u4e09\u5927\u7c7b<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5982\u4eca\uff0c\u201e\u514d\u75ab\u7ec6\u80de\u7597\u6cd5 \u201c\u4e00\u8bcd\u6db5\u76d6\u4e86\u80bf\u7624\u5b66\u9886\u57df\u4e09\u79cd\u4e0d\u540c\u7684\u4ea7\u54c1\u7c7b\u522b\uff1a<\/p>\n\n\n\n<p><strong>1. CAR-T \u7ec6\u80de\u7597\u6cd5<\/strong> (\u5d4c\u5408\u6297\u539f\u53d7\u4f53 T \u7ec6\u80de\uff09<br>\u7ecf\u8fc7\u57fa\u56e0\u6539\u9020\u7684 T \u7ec6\u80de\uff0c\u5177\u6709\u5408\u6210\u7684\u8868\u9762\u53d7\u4f53\uff0c\u53ef\u8bc6\u522b\u7ec6\u80de\u8868\u9762\u7684\u80bf\u7624\u6297\u539f\u3002\u8fc4\u4eca\u4e3a\u6b62\u83b7\u6279\u7684\u6240\u6709\u4ea7\u54c1\u90fd\u662f\u9488\u5bf9 CD19 \u6216 BCMA \u7684\uff0c\u5e76\u83b7\u51c6\u7528\u4e8e\u6cbb\u7597\u8840\u764c\u3002.<\/p>\n\n\n\n<p><strong>2. TCR-T \u7ec6\u80de\u7597\u6cd5<\/strong> (T \u7ec6\u80de\u53d7\u4f53 T \u7ec6\u80de\uff09\u3002<br>\u8f6c\u57fa\u56e0 T \u7ec6\u80de\u5177\u6709\u4f18\u5316\u7684\u5929\u7136 T \u7ec6\u80de\u53d7\u4f53\uff0c\u53ef\u8bc6\u522b HLA \u590d\u5408\u7269\u4e0a\u5448\u73b0\u7684\u7ec6\u80de\u5185\u80bf\u7624\u86cb\u767d\u30022024 \u5e74\u9996\u6b21\u83b7\u6279\u7528\u4e8e\u5b9e\u4f53\u7624\u6cbb\u7597\u3002.<\/p>\n\n\n\n<p><strong>\u7b2c 3 \u6b21 TIL \u6cbb\u7597<\/strong> (\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff09<br>\u4ece\u60a3\u8005\u80bf\u7624\u4e2d\u63d0\u53d6\u7684\u975e\u8f6c\u57fa\u56e0 T \u7ec6\u80de\uff0c\u7ecf\u8fc7\u5927\u91cf\u7e41\u6b96\u540e\u518d\u6ce8\u5165\u60a3\u8005\u4f53\u5185\u30022024 \u5e74\u9996\u6b21\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u3002.<\/p>\n\n\n\n<p>\u622a\u81f3 2024 \u5e74 12 \u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u53ca\u836f\u7269\u7ba1\u7406\u5c40\u5df2\u6279\u51c6\u4e86\u516d\u79cd CAR-T \u7ec6\u80de\u7597\u6cd5\uff0c\u5168\u7403\u5df2\u6709\u5341\u79cd CAR-T \u7ec6\u80de\u7597\u6cd5\u6295\u5165\u5546\u4e1a\u5e94\u7528\u3002\u6b64\u5916\uff0c\u8fd8\u6709\u4e00\u79cdTIL\u7597\u6cd5\uff08Lifileucel\uff09\u548c\u4e00\u79cdTCR\u7597\u6cd5\uff08Afamitresgene autoleucel\uff09--\u8fd9\u5728\u540c\u7c7b\u5b9e\u4f53\u7624\u7597\u6cd5\u4e2d\u5c1a\u5c5e\u9996\u4f8b\u3002. <a href=\"https:\/\/www.curemelanoma.org\/blog\/melanoma-clinical-trials-to-watch-fall-2025\" target=\"_blank\" rel=\"noreferrer noopener\">MRA<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"CAR-T-ZELLTHERAPIEN\"><\/span>CAR-T \u7ec6\u80de\u7597\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tisagenlecleucel_Kymriah%C2%AE_%E2%80%93_Novartis\"><\/span>Tisagenlecleucel\uff08Kymriah\u00ae\uff09 - <em>\u8bfa\u534e<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>\u76ee\u6807\u6297\u539f<\/strong> CD19 <br><strong>\u5df2\u6388\u6743\uff1a<\/strong> FDA 2017 \/ EMA 2018<br><strong>\u5168\u7403\u9996\u4e2a\u83b7\u6279\u7684 CAR-T \u4ea7\u54c1<\/strong><\/p>\n\n\n\n<p><strong>\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>25 \u5c81\u4ee5\u4e0b\u513f\u7ae5\u548c\u9752\u5c11\u5e74\uff1a\u590d\u53d1\/\u96be\u6cbb\u6027 B \u7ec6\u80de ALL\uff08\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff09<\/li>\n\n\n\n<li>\u6210\u4eba\uff1a\u2265 2 \u79cd\u7cfb\u7edf\u7597\u6cd5\u540e\u590d\u53d1\/\u96be\u6cbb\u7684\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624 (LBCL)<\/li>\n\n\n\n<li>\u590d\u53d1\/\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08FL\uff09<\/li>\n<\/ul>\n\n\n\n<p><strong>\u6700\u91cd\u8981\u7684\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ELIANA \u7814\u7a76\uff08\u6240\u6709\u513f\u79d1\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02435849\" target=\"_blank\" rel=\"noopener\">NCT02435849<\/a> | <a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.21.01019\" target=\"_blank\" rel=\"noopener\">JCO 2021<\/a><\/li>\n\n\n\n<li>JULIET \u7814\u7a76\uff08LBCL\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02445248\" target=\"_blank\" rel=\"noopener\">NCT02445248<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>\u6388\u6743\u673a\u6784<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40<\/li>\n\n\n\n<li>EMA<\/li>\n\n\n\n<li>TGA \uff08\u6fb3\u5927\u5229\u4e9a\uff09<\/li>\n\n\n\n<li>PMDA \uff08\u65e5\u672c\uff09 <\/li>\n<\/ul>\n\n\n\n<p><strong>\u5236\u9020\u5546\/\u7f51\u7ad9\uff1a<\/strong> <a href=\"https:\/\/www.novartis.com\/us-en\/sites\/novartis_us\/files\/kymriah.pdf\" target=\"_blank\" rel=\"noopener\">\u8bfa\u534e Kymriah<\/a><\/p>\n\n\n\n<p><strong>FDA \u4ea7\u54c1\u9875\u9762\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/kymriah\" target=\"_blank\" rel=\"noopener\">FDA Kymriah<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Axicabtagene_Ciloleucel_Yescarta%C2%AE_%E2%80%93_KiteGilead\"><\/span>Axicabtagene Ciloleucel\uff08Yescarta\u00ae\uff09 - <em>Kite\/Gilead<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>\u76ee\u6807\u6297\u539f<\/strong> CD19<br><strong>\u5df2\u6388\u6743\uff1a<\/strong> FDA 2017 \u5e74 10 \u6708 \/ EMA 2018 \u5e74 8 \u6708<\/p>\n\n\n\n<p><strong>\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\u3001PMBCL\u3001HGBCL\u3001tFL\uff09\u2265 2 \u79cd\u7cfb\u7edf\u7597\u6cd5\u540e<\/li>\n\n\n\n<li>\u539f\u53d1\u6027\u96be\u6cbb\u6027 DLBCL \u6216 12 \u4e2a\u6708\u5185\u590d\u53d1\uff08\u4e8c\u7ebf\u6cbb\u7597\uff09<\/li>\n\n\n\n<li>\u22652\u79cd\u7cfb\u7edf\u7597\u6cd5\u540e\u590d\u53d1\/\u96be\u6cbb\u7684\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624<\/li>\n<\/ul>\n\n\n\n<p><strong>\u6700\u91cd\u8981\u7684\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7956\u9a6c-1\uff08LBCL\uff0cORR 82 %\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02348216\" target=\"_blank\" rel=\"noopener\">NCT02348216<\/a> | <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1707447\" target=\"_blank\" rel=\"noopener\">NEJM 2017<\/a><\/li>\n\n\n\n<li>ZUMA-7\uff08\u4e8c\u7ebf\u7597\u6cd5 vs. ASCT\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03391466\" target=\"_blank\" rel=\"noopener\">NCT03391466<\/a><\/li>\n\n\n\n<li>ZUMA-5\uff08\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff0cORR &gt;90 %\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03105336\" target=\"_blank\" rel=\"noopener\">NCT03105336<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>\u6cbb\u7597\u4e2d\u5fc3\uff08D\/A\/CH \u9009\u62e9\uff09<\/strong><\/p>\n\n\n\n<p>\u6240\u6709\u83b7\u5f97 FACT\/JACIE \u8ba4\u8bc1\u7684\u5408\u683c\u79fb\u690d\u4e2d\u5fc3\uff1b\u5728\u5fb7\u56fd\uff0c\u5982\u6c49\u5821\u5927\u5b66\u533b\u7597\u4e2d\u5fc3\u3001\u67cf\u6797 Charit\u00e9\u3001\u6155\u5c3c\u9ed1\u5927\u5b66\u533b\u5b66\u9662\u3001\u6d77\u5fb7\u5821\u5927\u5b66\u533b\u7597\u4e2d\u5fc3\u3002.<\/p>\n\n\n\n<p><strong>\u5236\u9020\u5546\/\u7f51\u7ad9<\/strong>: <a href=\"https:\/\/www.yescarta.com\" target=\"_blank\" rel=\"noopener\">\u5409\u5229\u5fb7 Yescarta<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Brexucabtagene_Autoleucel_Tecartus%C2%AE_%E2%80%93_KiteGilead\"><\/span>Brexucabtagene Autoleucel (Tecartus\u00ae) - Brexucabtagene Autoleucel (Tecartus\u00ae) <em>Kite\/Gilead<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>\u76ee\u6807\u6297\u539f<\/strong> CD19<br><strong>\u5df2\u6388\u6743\uff1a<\/strong> FDA 2020 \u5e74 7 \u6708\uff08MCL\uff09\uff0c2021 \u5e74 10 \u6708\uff08\u6240\u6709\u6210\u4eba\uff09\/EMA 2020 \u5e74 12 \u6708<\/p>\n\n\n\n<p><strong>\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f7f\u7528 BTK \u6291\u5236\u5242\u540e\u590d\u53d1\/\u96be\u6cbb\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624 (MCL)<\/li>\n\n\n\n<li>\u590d\u53d1\/\u96be\u6cbb\u6027 B \u7ec6\u80de ALL \u6210\u4eba\u60a3\u8005<\/li>\n<\/ul>\n\n\n\n<p><strong>\u6700\u91cd\u8981\u7684\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ZUMA-2\uff08MCL\uff0cOS 12 \u4e2a\u6708\uff1a83 %\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02601313\" target=\"_blank\" rel=\"noopener\">NCT02601313<\/a><\/li>\n\n\n\n<li>ZUMA-3\uff08\u6210\u4eba B-ALL\uff0c\u4e2d\u4f4d OS 18.2 \u4e2a\u6708\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02614066\" target=\"_blank\" rel=\"noopener\">NCT02614066<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>FDA \u4ea7\u54c1\u9875\u9762\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/tecartus\" target=\"_blank\" rel=\"noopener\">FDA Tecartus<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lisocabtagene_Maraleucel_Breyanzi%C2%AE_%E2%80%93_Bristol_Myers_Squibb\"><\/span>Lisocabtagene Maraleucel (Breyanzi\u00ae) - Lisocabtagene Maraleucel (Breyanzi\u00ae) <em>\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>\u76ee\u6807\u6297\u539f<\/strong> CD19<br><strong>\u5df2\u6388\u6743\uff1a<\/strong> FDA 2021 \u5e74 2 \u6708\uff08\u521d\u59cb\uff09\/2022-2024 \u5e74\u6269\u5c55\u9002\u5e94\u75c7\/EMA 2022 \u5e74 10 \u6708<\/p>\n\n\n\n<p><strong>\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\uff08LBCL\u3001DLBCL\u3001HGBCL\u3001FL\uff09 \u4e8c\u7cfb + \u4e09\u7cfb<\/li>\n\n\n\n<li>\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\/\u5c0f\u7ec6\u80de\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u22652 \u79cd\u7597\u6cd5\uff08\u5305\u62ec BTK \u6291\u5236\u5242\uff09\u540e\uff08FDA 2024 \u5e74\u7248<\/li>\n\n\n\n<li>\u63a5\u53d7\u8fc7\u22652 \u79cd\u7cfb\u7edf\u7597\u6cd5\u7684\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624 (FL)<\/li>\n<\/ul>\n\n\n\n<p><strong>\u6700\u91cd\u8981\u7684\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>TRANSFORM\uff08\u4e8c\u7ebf DLBCL\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03575351\" target=\"_blank\" rel=\"noopener\">NCT03575351<\/a><\/li>\n\n\n\n<li>\u8d85\u8d8a-CLL-004\uff08CLL\/SLL\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03331198\" target=\"_blank\" rel=\"noopener\">NCT03331198<\/a> | <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(24)00422-7\/fulltext\" target=\"_blank\" rel=\"noopener\">\u67f3\u53f6\u5200 2024<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>FDA \u4ea7\u54c1\u9875\u9762\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/breyanzi\" target=\"_blank\" rel=\"noopener\">FDA Breyanzi<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Idecabtagene_Vicleucel_Abecma%C2%AE_%E2%80%93_Bristol_Myers_Squibb_2seventy_bio\"><\/span>Idecabtagene Vicleucel (Abecma\u00ae) - <em>Bristol Myers Squibb \/ 2seventy bio<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>\u76ee\u6807\u6297\u539f<\/strong> BCMA\uff08B\u7ec6\u80de\u6210\u719f\u6297\u539f\uff09<br><strong>\u5df2\u6388\u6743\uff1a<\/strong> FDA 2021 \u5e74 3 \u6708\/EMA 2021 \u5e74 8 \u6708<\/p>\n\n\n\n<p><strong>\u8bf4\u660e<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u65e2\u5f80\u63a5\u53d7\u8fc7\u22654 \u79cd\u6cbb\u7597\u540e\u590d\u53d1\/\u96be\u6cbb\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/li>\n<\/ul>\n\n\n\n<p><strong>\u6700\u91cd\u8981\u7684\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>KarMMa \u7814\u7a76\uff08ORR 73 %\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03361748\" target=\"_blank\" rel=\"noopener\">NCT03361748<\/a> | <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2024850\" target=\"_blank\" rel=\"noopener\">NEJM 2021<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>FDA \u4ea7\u54c1\u9875\u9762\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/abecma\" target=\"_blank\" rel=\"noopener\">FDA \u963f\u8d1d\u6b47\u9a6c<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ciltacabtagene_Autoleucel_Carvykti%C2%AE_%E2%80%93_JanssenLegend_Biotech\"><\/span>Ciltacabtagene Autoleucel\uff08Carvykti\u00ae\uff09- <em>\u6768\u68ee\/Legend \u751f\u7269\u6280\u672f\u516c\u53f8<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>\u76ee\u6807\u6297\u539f<\/strong> BCMA\uff08\u53cc\u7ed3\u5408\uff09<br><strong>\u5df2\u6388\u6743\uff1a<\/strong> FDA 2022 \u5e74 2 \u6708\uff08\u22654 \u6761\u751f\u4ea7\u7ebf\uff09\uff0c2024 \u5e74 4 \u6708\u5ef6\u671f\uff08\u22651 \u6761\u751f\u4ea7\u7ebf\uff09\/EMA 2022 \u5e74 5 \u6708<\/p>\n\n\n\n<p><strong>\u7279\u8f91<\/strong> \u72ec\u7279\u7684\u53cc\u6297\u4f53 CAR\uff0c\u542b\u6709\u4e24\u79cd\u7ed3\u5408 BCMA \u7684\u5355\u57df\u6297\u4f53\uff1b\u88ab\u8ba4\u4e3a\u662f\u8fc4\u4eca\u4e3a\u6b62\u83b7\u6279\u7684\u6700\u6709\u6548\u9aa8\u9ad3\u7624\u7597\u6cd5<\/p>\n\n\n\n<p><strong>\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7ecf\u22654 \u79cd\u7597\u6cd5\u6cbb\u7597\u540e\u590d\u53d1\/\u96be\u6cbb\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/li>\n\n\n\n<li>\u81ea 2024 \u5e74 4 \u6708\u8d77\uff08FDA\uff09\uff1a\u6765\u90a3\u5ea6\u80fa\u96be\u6cbb\u6027\u75be\u75c5\u2265\u4e00\u7ebf\u6cbb\u7597\u540e<\/li>\n<\/ul>\n\n\n\n<p><strong>\u6700\u91cd\u8981\u7684\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cartitude-1\uff08ORR 98 %\u3001CR 78 %\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03548207\" target=\"_blank\" rel=\"noopener\">NCT03548207<\/a> | <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(21)00933-4\/fulltext\" target=\"_blank\" rel=\"noopener\">\u67f3\u53f6\u5200 2021<\/a><\/li>\n\n\n\n<li>CARTITUDE-4\uff08\u7b2c 3 \u9636\u6bb5\uff0c\u5ef6\u957f\u9996\u6b21\u590d\u53d1\u671f\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04181827\" target=\"_blank\" rel=\"noopener\">NCT04181827<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>FDA \u4ea7\u54c1\u9875\u9762\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/carvykti\" target=\"_blank\" rel=\"noopener\">FDA Carvykti<\/a><br><strong>\u5236\u9020\u5546\uff1a<\/strong> <a href=\"https:\/\/www.carvykti.com\" target=\"_blank\" rel=\"noopener\">carvykti.com<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Obecabtagene_Autoleucel_Aucatzyl%C2%AE_%E2%80%93_Autolus_neu_112024\"><\/span>Obecabtagene Autoleucel\uff08Aucatzyl\u00ae\uff09- <em>Autolus<\/em> <em>(\u65b0\uff1a11.2024)<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>\u76ee\u6807\u6297\u539f<\/strong> CD19\uff08\u5feb\u901f\u8131\u673a\u8bbe\u8ba1--\u6bd2\u6027\u4f4e\u4e8e\u524d\u4ee3\u4ea7\u54c1\uff09<br><strong>\u5df2\u6388\u6743\uff1a<\/strong> 2024 \u5e74 11 \u6708 8 \u65e5<\/p>\n\n\n\n<p><strong>\u8bf4\u660e<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u590d\u53d1\/\u96be\u6cbb\u6027 B \u7ec6\u80de ALL \u6210\u4eba\u60a3\u8005<\/li>\n<\/ul>\n\n\n\n<p><strong>\u7279\u8f91<\/strong> \u9996\u4e2a\u672a\u7ecf REMS\uff08\u98ce\u9669\u8bc4\u4f30\u4e0e\u7f13\u89e3\u7b56\u7565\uff09\u8ba1\u5212\u6279\u51c6\u7684 CAR-T \u4ea7\u54c1\uff1b\u8fd9\u6807\u5fd7\u7740\u5b89\u5168\u6027\u548c\u65b0\u578b CD19 \u7ed3\u5408\u6982\u5ff5\u7684\u63d0\u9ad8\u3002.<br><a href=\"https:\/\/www.dasgelbeblatt.de\/welt\/immunzelltherapie-heilt-ueberraschend-krebs-bei-einem-jugendlichen-zr-94168662.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u9ec4\u53f6<\/a><\/p>\n\n\n\n<p><strong>\u6700\u91cd\u8981\u7684\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>FELIX \u7814\u7a76\uff081\/2 \u671f\uff0c3 \u4e2a\u6708\u5185 CR \u7387\u4e3a 42 %\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04404660\" target=\"_blank\" rel=\"noopener\">NCT04404660<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>FDA \u4ea7\u54c1\u9875\u9762\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/aucatzyl\" target=\"_blank\" rel=\"noopener\">\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40(FDA)<\/a><br><strong>\u5236\u9020\u5546\uff1a<\/strong> <a href=\"https:\/\/www.autolus.com\" target=\"_blank\" rel=\"noopener\">autolus.com<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"WELTWEIT_ZUGELASSEN_%E2%80%93_NICHT_IN_USAEU_weitere_Lander\"><\/span>\u5168\u7403\u5141\u8bb8 - \u7f8e\u56fd\/\u6b27\u76df\uff08\u5176\u4ed6\u56fd\u5bb6\uff09\u4e0d\u5141\u8bb8<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"China_NMPA_%E2%80%93_vier_zusatzliche_CAR-T-Produkte\"><\/span>\u4e2d\u56fd\uff08NMPA\uff09--\u65b0\u589e\u56db\u79cd CAR-T \u4ea7\u54c1<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5168\u7403\u5171\u6709 11 \u79cd\u81ea\u4f53 CAR-T \u7ec6\u80de\u7597\u6cd5\u83b7\u5f97\u4e86\u521d\u6b65\u6279\u51c6\u3002\u5176\u4e2d\u4e03\u9879\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\uff0c\u56db\u9879\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\uff08NMPA\uff09\u6279\u51c6\uff0c\u5747\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u8840\u6db2\u6076\u6027\u80bf\u7624\u3002.<br><a href=\"https:\/\/ucla.clinicaltrials.researcherprofiles.org\/trial\/NCT06743126\" target=\"_blank\" rel=\"noreferrer noopener\">Immatics US, Inc.<\/a><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u5546\u54c1\u540d\u79f0<\/th><th>\u6d3b\u6027\u6210\u5206<\/th><th>\u76ee\u6807\u6297\u539f<\/th><th>\u8bf4\u660e<\/th><th>\u6388\u6743<\/th><\/tr><\/thead><tbody><tr><td>\u5361\u6cf0\u74e6<\/td><td>Relmacabtagene autoleucel<\/td><td>BCMA<\/td><td>\u591a\u79cd\u3002\u9aa8\u9ad3\u7624\u3001DLBCL<\/td><td>NMPA 2021\/2023<\/td><\/tr><tr><td>\u5bcc\u5361\u7d22<\/td><td>Equecabtagene autoleucel<\/td><td>BCMA<\/td><td>\u591a\u3002\u9aa8\u9ad3\u7624<\/td><td>NMPA 2023<\/td><\/tr><tr><td>\u5143\u745e\u8fbe<\/td><td>Satricabtagene autoleucel<\/td><td>CD19<\/td><td>B \u7ec6\u80de\u6dcb\u5df4\u7624<\/td><td>NMPA<\/td><\/tr><tr><td>Zever-cel<\/td><td>\u2014<\/td><td>CD19\/BCMA<\/td><td>Haematolog.<\/td><td>NMPA<\/td><\/tr><tr><td>Carvykti<\/td><td>Ciltacabtagene autoleucel<\/td><td>BCMA<\/td><td>\u591a\u3002\u9aa8\u9ad3\u7624<\/td><td>NMPA 2024<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Indien_CDSCO\"><\/span>\u5370\u5ea6\uff08CDSCO\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>NexCAR19<\/strong> (Actalycabtagene autoleucel\uff09\u4e8e 2023 \u5e74 10 \u6708\u83b7\u5f97\u6279\u51c6\uff0c\u6210\u4e3a\u5370\u5ea6\u5f00\u53d1\u7684\u7b2c\u4e00\u79cd CAR-T \u7597\u6cd5\u3002\u8be5\u7597\u6cd5\u7531\u5370\u5ea6\u7406\u5de5\u5b66\u9662\u5b5f\u4e70\u5206\u6821\u7684ImmunoACT\u5f00\u53d1\uff0c\u4ef7\u683c\u7ea6\u4e3a5\u4e07\u7f8e\u5143\uff0c\u7ea6\u4e3a\u897f\u65b9\u540c\u7c7b\u4ea7\u54c1\u7684\u5341\u5206\u4e4b\u4e00\u3002. <a href=\"https:\/\/www.dasgelbeblatt.de\/welt\/immunzelltherapie-heilt-ueberraschend-krebs-bei-einem-jugendlichen-zr-94168662.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u9ec4\u53f6<\/a><\/p>\n\n\n\n<p><strong>\u8bf4\u660e<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u590d\u53d1\/\u96be\u6cbb\u6027 B \u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u548c B \u7ec6\u80de ALL<\/li>\n<\/ul>\n\n\n\n<p><strong>\u6cbb\u7597\u4e2d\u5fc3\uff1a<\/strong> \u5b5f\u4e70\u5854\u5854\u7eaa\u5ff5\u533b\u9662 <br><strong>\u5236\u9020\u5546\uff1a<\/strong> <a href=\"https:\/\/www.immunoact.com\" target=\"_blank\" rel=\"noopener\">\u514d\u75abACT<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TCR-T-ZELLTHERAPIEN_zugelassen\"><\/span>TCR-T \u7ec6\u80de\u7597\u6cd5\uff08\u5df2\u83b7\u6388\u6743\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Afamitresgene_Autoleucel_Tecelra%C2%AE_%E2%80%93_Adaptimmune_August_2024\"><\/span>Afamitresgene Autoleucel\uff08Tecelra\u00ae\uff09- <em>\u9002\u5e94\u514d\u75ab<\/em> <em>(2024 \u5e74 8 \u6708\uff09<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>2024 \u5e74 8 \u6708 2 \u65e5\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u6279\u51c6\u4e86 Afamitresgene autoleucel\uff08Afami-cel\uff0cTecelra\uff09\u4f5c\u4e3a\u6709\u53f2\u4ee5\u6765\u7b2c\u4e00\u79cd\u6cbb\u7597\u764c\u75c7\u7684 TCR T \u7ec6\u80de\u7597\u6cd5\uff0c\u7279\u522b\u662f\u7b2c\u4e00\u79cd\u6cbb\u7597\u5b9e\u4f53\u7624\u7684\u57fa\u56e0\u5de5\u7a0b T \u7ec6\u80de\u4ea7\u54c1\u3002. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12283372\/\" target=\"_blank\" rel=\"noreferrer noopener\">PubMed Central<\/a><\/p>\n\n\n\n<p><strong>\u76ee\u6807\u6297\u539f<\/strong> MAGE-A4\uff08\u7ec6\u80de\u5185\u764c\u75c7\u777e\u4e38\u6297\u539f\uff09\uff0c\u7531 HLA-A*02:01 \u5448\u9012<br><strong>\u5df2\u6388\u6743\uff1a<\/strong> \u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40 2024 \u5e74 8 \u6708<\/p>\n\n\n\n<p><strong>\u8bf4\u660e<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u60a3\u6709\u65e0\u6cd5\u5207\u9664\u6216\u8f6c\u79fb\u7684\u764c\u75c7\u7684\u6210\u4eba <strong>\u6ed1\u819c\u8089\u7624<\/strong> (\u8f6f\u7ec4\u7ec7\u8089\u7624\uff09\uff0c\u5316\u7597\u524d\u6cbb\u7597\uff0cMAGE-A4 \u9633\u6027\uff0cHLA-A*02:01 \u9633\u6027<\/li>\n<\/ul>\n\n\n\n<p>\u5728\u5173\u952e\u7684 SPEARHEAD-1 2 \u671f\u8bd5\u9a8c\u4e2d\uff0c\u6ed1\u819c\u8089\u7624\u60a3\u8005\u7684\u80bf\u7624\u5bf9\u6cbb\u7597\u7684\u53cd\u5e94\u65f6\u95f4\u4e2d\u4f4d\u6570\u4e3a 11.6 \u4e2a\u6708\u3002\u6709\u4e9b\u60a3\u8005\u5728\u6570\u5e74\u5185\u90fd\u672a\u53d1\u73b0\u80bf\u7624\u3002. <a href=\"https:\/\/www.clinicaltrialvanguard.com\/news\/t-knife-files-for-phase-1-trial-of-prame-t-cell-therapy\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u4e34\u5e8a\u8bd5\u9a8c\u5148\u950b<\/a><\/p>\n\n\n\n<p><strong>\u6700\u91cd\u8981\u7684\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>SPEARHEAD-1\uff08\u7b2c 2 \u9636\u6bb5\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04044858\" target=\"_blank\" rel=\"noopener\">NCT04044858<\/a> | <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(24)00319-2\/fulltext\" target=\"_blank\" rel=\"noopener\">\u67f3\u53f6\u5200\u300b2024 \u5e74 4 \u6708<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>\u6cbb\u7597\u4e2d\u5fc3\uff08\u5148\u950b\uff09\uff1a<\/strong> \u7ebd\u7ea6\u65af\u9686-\u51ef\u7279\u7433\u7eaa\u5ff5\u764c\u75c7\u4e2d\u5fc3 <a href=\"https:\/\/www.mskcc.org\/news\/immunotherapy-clinical-trial-shows-promise-for-treating-rare-sarcomas\" target=\"_blank\" rel=\"noopener\">MSK Tecelra \u4fe1\u606f<\/a><br><strong>FDA \u4ea7\u54c1\u9875\u9762\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/tecelra\" target=\"_blank\" rel=\"noopener\">FDA Tecelra<\/a> <br><strong>NCI \u6587\u7ae0\uff1a<\/strong> <a href=\"https:\/\/www.cancer.gov\/news-events\/cancer-currents-blog\/2024\/fda-tecelra-synovial-sarcoma-mage-a4\" target=\"_blank\" rel=\"noopener\">cancer.gov TCR\u7597\u6cd5<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tebentafusp-tebn_Kimmtrak%C2%AE_%E2%80%93_Immunocore_Januar_2022\"><\/span>Tebentafusp-tebn\uff08Kimmtrak\u00ae\uff09 - <em>\u514d\u75ab\u6838\u5fc3<\/em> <em>(2022 \u5e74 1 \u6708\uff09<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5b83\u4e0d\u662f\u4e00\u79cd\u5178\u578b\u7684\u7ec6\u80de\u4ea7\u54c1\uff08\u4e0d\u662f\u8f93\u6ce8 T \u7ec6\u80de\u4ea7\u54c1\uff09\uff0c\u800c\u662f\u4e00\u79cd\u53cc\u7279\u5f02\u6027 TCR \u878d\u5408\u86cb\u767d\uff0c\u4f46\u4ece\u673a\u7406\u4e0a\u8bb2\uff0c\u5b83\u5c5e\u4e8e\u57fa\u4e8e TCR \u7684\u514d\u75ab\u7597\u6cd5\uff0c\u7ecf\u5e38\u88ab\u5f53\u4f5c PRAME-TCER\u00ae \u6280\u672f\u7684\u524d\u8eab\u6765\u8ba8\u8bba\u3002.<\/p>\n\n\n\n<p><strong>\u673a\u5236\uff1a<\/strong> \u4e00\u9762\u4e0e\u80bf\u7624\u7ec6\u80de\u4e0a\u7684 gp100 \u80bd+HLA-A*02:01 \u7ed3\u5408\uff0c\u53e6\u4e00\u9762\u4e0e T \u7ec6\u80de\u4e0a\u7684 CD3 \u7ed3\u5408\uff08ImmTAC \u6280\u672f\uff09\u3002.<br><strong>\u5df2\u6388\u6743\uff1a<\/strong> FDA 2022 \u5e74 1 \u6708 \/ EMA 2022 \u5e74 2 \u6708<\/p>\n\n\n\n<p><strong>\u6307\u793a\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>HLA-A*02:01 \u9633\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u764c\u75c7\u6210\u4eba\u60a3\u8005 <strong>\u773c\u8272\u7d20\u5c42\u9ed1\u8272\u7d20\u7624<\/strong> (\u773c\u90e8\u9ed1\u8272\u7d20\u7624\uff09- \u7b2c\u4e00\u7ebf<\/li>\n<\/ul>\n\n\n\n<p><strong>\u7279\u8f91<\/strong> \u6709\u53f2\u4ee5\u6765\u9996\u4e2a\u83b7\u51c6\u7528\u4e8e\u6cbb\u7597\u8461\u8404\u819c\u9ed1\u8272\u7d20\u7624\u7684\u836f\u7269<\/p>\n\n\n\n<p>\u5728IMCgp100-202\u76843\u671f\u7814\u7a76\u4e2d\uff0c\u7279\u672c\u4f10\u65af\u666e\u7684\u751f\u5b58\u671f\u660e\u663e\u4f18\u4e8e\u533b\u751f\u7684\u9009\u62e9\uff08pembrolizumab\u3001ipilimumab\u6216dacarbazine\uff09\uff1a\u4e2d\u4f4dOS 21.7\u4e2a\u6708\u5bf916.0\u4e2a\u6708\uff08HR 0.51\uff1bp&lt;0.0001\uff09\u30021\u5e74OS\u7387\u4e3a73 %\u5bf959 %\u3002. <a href=\"https:\/\/www.kitz-heidelberg.de\/das-kitz\/kitz-programme\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u57fa\u8328-\u6d77\u5fb7\u5821<\/a><\/p>\n\n\n\n<p><strong>\u6700\u91cd\u8981\u7684\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>IMCgp100-202\uff08\u7b2c 3 \u9636\u6bb5\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03070392\" target=\"_blank\" rel=\"noopener\">NCT03070392<\/a> | <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2103485\" target=\"_blank\" rel=\"noopener\">NEJM 2021<\/a> | <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2304753\" target=\"_blank\" rel=\"noopener\">3 \u5e74\u66f4\u65b0 NEJM 2023<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>FDA page\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-disco-burst-edition-fda-approves-tebentafusp-tebn-unresectable-or-metastatic-uveal-melanoma\" target=\"_blank\" rel=\"noopener\">fda.gov Kimmtrak<\/a> <br><strong>\u5236\u9020\u5546\uff1a<\/strong> <a href=\"https:\/\/www.immunocore.com\/pipeline\/kimmtrak\" target=\"_blank\" rel=\"noopener\">immunocore.com\/kimmtrak<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TIL-THERAPIE_zugelassen\"><\/span>TIL-THERAPY \uff08\u6388\u6743\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lifileucel_Amtagvi%C2%AE_%E2%80%93_Iovance_Biotherapeutics_Februar_2024\"><\/span>Lifileucel\uff08Amtagvi\u00ae\uff09- <em>Iovance \u751f\u7269\u6cbb\u7597<\/em> <em>(2024 \u5e74 2 \u6708\uff09<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Lifileucel \u4e8e 2024 \u5e74 2 \u6708 16 \u65e5\u83b7\u5f97\u6279\u51c6\uff0c\u662f\u6709\u53f2\u4ee5\u6765\u7b2c\u4e00\u79cd\u6cbb\u7597\u5b9e\u4f53\u7624\u7684 T \u7ec6\u80de\u7597\u6cd5\uff0c\u4e5f\u662f\u5386\u53f2\u4e0a\u7b2c\u4e00\u79cd TIL \u7597\u6cd5\u3002. <a href=\"https:\/\/investors.immatics.com\/news-releases\/news-release-details\/immatics-initiates-phase-12-clinical-trial-evaluate-prame-tcr\/\" target=\"_blank\" rel=\"noreferrer noopener\">Immatics N.V.<\/a><\/p>\n\n\n\n<p><strong>\u673a\u5236\uff1a<\/strong> \u901a\u8fc7\u624b\u672f\u5207\u9664\u80bf\u7624\uff0c\u5206\u79bb\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TIL\uff09\uff0c\u4f7f\u5176\u5927\u91cf\u7e41\u6b96\uff0c\u5e76\u5728\u6dcb\u5df4\u6d88\u8017\u540e\u91cd\u65b0\u704c\u6ce8\u3002\u4e0d\u8fdb\u884c\u57fa\u56e0\u6539\u9020--\u4f7f\u7528 TIL \u7684\u5929\u7136\u80bf\u7624\u8bc6\u522b\u80fd\u529b\u3002.<\/p>\n\n\n\n<p><strong>\u8bf4\u660e<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u60a3\u6709\u65e0\u6cd5\u5207\u9664\u6216\u8f6c\u79fb\u7684\u764c\u75c7\u7684\u6210\u4eba <strong>\u9ed1\u8272\u7d20\u7624<\/strong> (\u66fe\u63a5\u53d7\u6297PD-1\u7597\u6cd5\u548cBRAF\/MEK\u6291\u5236\u5242\uff08\u5982BRAF\u7a81\u53d8\uff09\u6cbb\u7597\u7684\u76ae\u80a4\u9ed1\u8272\u7d20\u7624\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u5728\u4e3a\u671f 5 \u5e74\u7684 C-144-01 2 \u671f\u968f\u8bbf\u7814\u7a76\u4e2d\uff0cLifileucel \u7684\u5ba2\u89c2\u53cd\u5e94\u7387\u4e3a 31.4 %\uff0c\u4e2d\u4f4d\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\u4e3a 36.5 \u4e2a\u6708\uff0c\u8d85\u8fc7 30 \u540d % \u53cd\u5e94\u8005\u51fa\u73b0\u4e86\u6301\u7eed\u7684\u957f\u671f\u53cd\u5e94\u3002. <a href=\"https:\/\/dailyreporter.esmo.org\/esmo-immuno-oncology-congress-2025\/news\/next-generation-prame-directed-tcr-t-cell-therapy-shows-early-activity-in-solid-tumours\" target=\"_blank\" rel=\"noreferrer noopener\">\u57c3\u65af\u83ab<\/a><\/p>\n\n\n\n<p><strong>\u6700\u91cd\u8981\u7684\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>C-144-01\uff08\u7b2c 2 \u9636\u6bb5\uff0cNCT02360579\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02360579\" target=\"_blank\" rel=\"noopener\">\u4e34\u5e8a\u8bd5\u9a8c<\/a> | <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40699950\/\" target=\"_blank\" rel=\"noopener\">\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u6279\u51c6\u6458\u8981<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>\u6cbb\u7597\u4e2d\u5fc3\uff08\u7f8e\u56fd\u9009\u62e9\uff09\uff1a<\/strong> \u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\u3001\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u3001\u5b89\u5fb7\u68ee\u533b\u5b66\u535a\u58eb\u3001\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u3001\u65af\u9686\u51ef\u7279\u7433\u7eaa\u5ff5\u533b\u9662\u3001\u6885\u5965\u8bca\u6240<br><strong>NCI \u6587\u7ae0\uff1a<\/strong> <a href=\"https:\/\/www.cancer.gov\/news-events\/cancer-currents-blog\/2024\/fda-amtagvi-til-therapy-melanoma\" target=\"_blank\" rel=\"noopener\">cancer.gov TIL\u7597\u6cd5<\/a><br><strong>\u5236\u9020\u5546\uff1a<\/strong> <a href=\"https:\/\/www.iovance.com\" target=\"_blank\" rel=\"noopener\">iovance.com<\/a><br><strong>FDA \u4ea7\u54c1\u9875\u9762\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/amtagvi\" target=\"_blank\" rel=\"noopener\">FDA Amtagvi<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ubersicht_aller_Immunzelltherapien_weltweit\"><\/span>\u5168\u7403\u6240\u6709\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u6982\u89c8<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u4ea7\u54c1<\/th><th>\u6d3b\u6027\u6210\u5206<\/th><th>\u7c7b\u578b<\/th><th>\u76ee\u6807<\/th><th>\u8bf4\u660e<\/th><th>\u6388\u6743<\/th><th>\u5e74\u4efd<\/th><\/tr><\/thead><tbody><tr><td><strong>\u57fa\u59c6\u91cc\u4e9a<\/strong><\/td><td>Tisagenlecleucel<\/td><td>CAR-T<\/td><td>CD19<\/td><td>\u513f\u79d1 B-ALL\u3001LBCL\u3001FL<\/td><td>FDA, EMA<\/td><td>2017<\/td><\/tr><tr><td><strong>Yescarta<\/strong><\/td><td>Axicabtagene-cel<\/td><td>CAR-T<\/td><td>CD19<\/td><td>DLBCL\u3001PMBCL\u3001FL\u3001tFL<\/td><td>FDA, EMA<\/td><td>2017<\/td><\/tr><tr><td><strong>Tecartus<\/strong><\/td><td>Brexucabtagene-cel<\/td><td>CAR-T<\/td><td>CD19<\/td><td>MCL, \u6210\u4eba B-ALL<\/td><td>FDA, EMA<\/td><td>2020<\/td><\/tr><tr><td><strong>\u5e03\u96f7\u626c\u9f50<\/strong><\/td><td>Lisocabtagene-cel<\/td><td>CAR-T<\/td><td>CD19<\/td><td>LBCL\u3001CLL\/SLL\u3001FL<\/td><td>FDA, EMA<\/td><td>2021<\/td><\/tr><tr><td><strong>\u963f\u8d1d\u5361<\/strong><\/td><td>Idecabtagene-cel<\/td><td>CAR-T<\/td><td>BCMA<\/td><td>\u591a\u79cd\u3002\u9aa8\u9ad3\u7624 \u22654\u884c<\/td><td>FDA, EMA<\/td><td>2021<\/td><\/tr><tr><td><strong>Carvykti<\/strong><\/td><td>Ciltacabtagene-cel<\/td><td>CAR-T<\/td><td>BCMA<\/td><td>\u591a\u79cd\u3002\u9aa8\u9ad3\u7624 \u22651\u7ebf<\/td><td>FDA, EMA, NMPA<\/td><td>2022<\/td><\/tr><tr><td><strong>Kimmtrak<\/strong><\/td><td>Tebentafusp-tebn<\/td><td>TCR \u53cc\u7279\u5f02\u6027<\/td><td>gp100+HLA<\/td><td>\u773c\u8272\u7d20\u5c42\u9ed1\u8272\u7d20\u7624<\/td><td>FDA, EMA<\/td><td>2022<\/td><\/tr><tr><td><strong>NexCAR19<\/strong><\/td><td>Actalycabtagene-cel<\/td><td>CAR-T<\/td><td>CD19<\/td><td>B-ALL, NHL<\/td><td>CDSCO\uff08\u5370\u5ea6\uff09<\/td><td>2023<\/td><\/tr><tr><td><strong>Amtagvi<\/strong><\/td><td>Lifileucel<\/td><td>TIL<\/td><td>\u591a\u514b\u9686<\/td><td>\u9ed1\u8272\u7d20\u7624\uff08\u5b9e\u4f53\u7624\uff09<\/td><td>\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40<\/td><td>2024<\/td><\/tr><tr><td><strong>Tecelra<\/strong><\/td><td>Afamitresgene-cel<\/td><td>TCR-T<\/td><td>MAGE-A4+HLA<\/td><td>\u6ed1\u819c\u8089\u7624<\/td><td>\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40<\/td><td>2024<\/td><\/tr><tr><td><strong>Aucatzyl<\/strong><\/td><td>Obecabtagene-cel<\/td><td>CAR-T<\/td><td>CD19<\/td><td>\u6210\u4eba B-ALL<\/td><td>\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40<\/td><td>2024<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nebenwirkungen_%E2%80%93_Was_alle_Therapien_verbindet\"><\/span>\u526f\u4f5c\u7528--\u6240\u6709\u7597\u6cd5\u7684\u5171\u540c\u70b9<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u6700\u91cd\u8981\u7684\u5e38\u89c1\u98ce\u9669\uff1a<\/p>\n\n\n\n<p><strong>\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\uff08CRS\uff09<\/strong><br>CAR-T \u548c TCR-T \u5e38\u5e38\u53d1\u751f\uff1bTIL \u5f88\u5c11\u53d1\u751f\u3002.<br>\u4f7f\u7528\u6258\u897f\u73e0\u5355\u6297\u6cbb\u7597\u3002.<br>\u81ea 2024 \u5e74\u8d77\uff0c\u5728\u6240\u6709 CAR-T \u6807\u7b7e\u4e0a\uff1a\u9488\u5bf9\u7ee7\u53d1\u6027 T \u7ec6\u80de\u6076\u6027\u80bf\u7624\u7684\u6846\u6ce8\u8b66\u544a\uff08\u975e\u5e38\u7f55\u89c1\uff0c\u51e0\u5e74\u5185\u7ea6\u4e3a 3.6 %\uff09\u3002.<\/p>\n\n\n\n<p><strong>ICANS\uff08\u795e\u7ecf\u6bd2\u6027\uff09<\/strong><br>\u514d\u75ab\u7ec6\u80de\u76f8\u5173\u795e\u7ecf\u6bd2\u6027\u7efc\u5408\u5f81\uff1b\u5728 CAR-T \u4e2d\u5df2\u77e5\uff0c\u5728 TIL \u4e2d\u8f83\u5c11\u89c1\u3002.<\/p>\n\n\n\n<p><strong>\u7ec6\u80de\u51cf\u5c11\u75c7<\/strong><br>\u5fc5\u8981\u7684\u6dcb\u5df4\u6d88\u8017\uff08\u8f93\u6db2\u524d\u7684\u5316\u7597\uff09\u603b\u4f1a\u5bfc\u81f4\u77ed\u671f\u7684\u8840\u7ec6\u80de\u8ba1\u6570\u53d8\u5316\u3002.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wo_werden_diese_Therapien_in_Deutschland_angeboten\"><\/span>\u8fd9\u4e9b\u7597\u6cd5\u5728\u5fb7\u56fd\u54ea\u4e9b\u5730\u65b9\u63d0\u4f9b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u6240\u6709\u7ecf FDA\/EMA \u6279\u51c6\u7684 CAR-T \u4ea7\u54c1\u5747\u5728\u7f8e\u56fd\u751f\u4ea7\u3002 <strong>\u4e13\u4e1a\u79fb\u690d\u4e2d\u5fc3<\/strong> \u7531\u5236\u9020\u5546\u8ba4\u8bc1\u5e76\u7ecf DKMS\/EBMT \u8ba4\u53ef\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6c49\u5821-\u57c3\u5f6d\u591a\u592b\u5927\u5b66\u533b\u7597\u4e2d\u5fc3\uff08UKE\uff09\uff1a<\/strong> <a href=\"https:\/\/www.uke.de\" target=\"_blank\" rel=\"noopener\">uke.de<\/a><\/li>\n\n\n\n<li><strong>Charit\u00e9 - Universit\u00e4tsmedizin Berlin\uff1a<\/strong> <a href=\"https:\/\/www.charite.de\" target=\"_blank\" rel=\"noopener\">charite.de<\/a><\/li>\n\n\n\n<li><strong>\u6155\u5c3c\u9ed1 LMU \u4e34\u5e8a\u4e2d\u5fc3\uff1a<\/strong> <a href=\"https:\/\/www.lmu-klinikum.de\" target=\"_blank\" rel=\"noopener\">lmu-klinikum.de<\/a><\/li>\n\n\n\n<li><strong>\u6d77\u5fb7\u5821\u5927\u5b66\u533b\u9662\/KiTZ\uff1a<\/strong> <a href=\"https:\/\/www.kitz-heidelberg.de\" target=\"_blank\" rel=\"noopener\">kitz-heidelberg.de<\/a> <em>(\u53e6\u89c1\uff1aPRAME \u7814\u7a76\uff09<\/em><\/li>\n\n\n\n<li><strong>\u6cd5\u5170\u514b\u798f\u5927\u5b66\u533b\u9662\uff1a<\/strong> <a href=\"https:\/\/www.uniklinik-frankfurt.de\" target=\"_blank\" rel=\"noopener\">uniklinik-frankfurt.de<\/a><\/li>\n\n\n\n<li><strong>\u5f17\u83b1\u5821\u5927\u5b66\u533b\u7597\u4e2d\u5fc3\uff1a<\/strong> <a href=\"https:\/\/www.uniklinik-freiburg.de\" target=\"_blank\" rel=\"noopener\">uniklinik-freiburg.de<\/a><\/li>\n\n\n\n<li><strong>\u675c\u585e\u5c14\u591a\u592b\/\u57c3\u68ee\u5927\u5b66\u533b\u9662\uff1a<\/strong> \u4e13\u653b MCL\/DLBCL-CAR-T<\/li>\n<\/ul>\n\n\n\n<p><strong>\u7ecf\u8ba4\u8bc1\u7684 CAR-T \u4e2d\u5fc3\u5b8c\u6574\u5217\u8868\uff1a<\/strong> <a href=\"https:\/\/www.ebmt.org\/registry\/center-search\" target=\"_blank\" rel=\"noopener\">EBMT \u4e2d\u5fc3\u641c\u7d22<\/a><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ausblick_Was_kommt_als_nachstes\"><\/span>\u5c55\u671b\uff1a\u4e0b\u4e00\u6b65\u662f\u4ec0\u4e48\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u4e0b\u4e00\u6ce2\u83b7\u6279\u7684\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u9884\u8ba1\u5c06\u4e8e 2026-2028 \u5e74\u95ee\u4e16\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IMA203 \/ Anzu-cel (PRAME-TCR)\uff1a<\/strong> \u6b63\u5728\u8fdb\u884c SUPRAME 3 \u671f\u8bd5\u9a8c <em>\u9ed1\u8272\u7d20\u7624\u7684\u53ef\u80fd\u6388\u6743 2027\/2028<\/em><\/li>\n\n\n\n<li><strong>Lifileucel + pembrolizumab\uff08\u7b2c 3 \u9636\u6bb5\uff09\uff1a<\/strong> NCT05727904 - \u4e00\u7ebf\u7814\u7a76 <em>\u9ed1\u8272\u7d20\u7624\u4e00\u7ebf\u6cbb\u7597\u53ef\u80fd\u83b7\u6279<\/em><\/li>\n\n\n\n<li><strong>Brenetafusp (PRISM-MEL-301)\uff1a<\/strong> 3\u671f\u7814\u7a76 PRAME\u00d7CD3-\u53cc\u7279\u5f02\u6027 <em>2027 \u5e74\u53ef\u80fd\u83b7\u5f97\u6388\u6743<\/em><\/li>\n\n\n\n<li><strong>\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff08\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3001\u591a\u53d1\u6027\u786c\u5316\u75c7\uff09\u7684 CAR-T\uff1a<\/strong> \u6b63\u5728\u8fdb\u884c\u7b2c\u4e8c\u9636\u6bb5\u8bd5\u9a8c\uff1b\u53ef\u80fd\u662f\u9996\u4e2a\u975e\u80bf\u7624 CAR-T \u4ea7\u54c1<\/li>\n\n\n\n<li><strong>KiTZ \u6d77\u5fb7\u5821\u513f\u79d1 PRAME \u7814\u7a76\uff1a<\/strong> \u8ba1\u5212\u4e8e 2026 \u5e74\u5efa\u6210 - \u4e16\u754c\u4e0a\u7b2c\u4e00\u4e2a\u513f\u7ae5\u7814\u7a76\u4e2d\u5fc3<\/li>\n<\/ul>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"GKV-Erstattung_von_Immunzelltherapien_in_Deutschland\"><\/span>\u5fb7\u56fd\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u7684 SHI \u62a5\u9500<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p>\u72b6\u6001 02.2026<\/p>\n\n\n\n<p>\u60c5\u51b5\u5f88\u590d\u6742\uff0c\u56e0\u6cbb\u7597\u65b9\u6cd5\u3001\u4ea7\u54c1\u548c\u533b\u7597\u4fdd\u9669\u516c\u53f8\u7684\u4e0d\u540c\u800c\u6709\u5f88\u5927\u5dee\u5f02\u3002\u6ca1\u6709\u50cf\u4f20\u7edf\u836f\u7269\u90a3\u6837\u7684\u7edf\u4e00\u8d39\u7387\u548c\u81ea\u52a8\u62a5\u9500\u3002\u53d6\u800c\u4ee3\u4e4b\u7684\u662f\u4e00\u4e2a\u591a\u9636\u6bb5\u7cfb\u7edf\uff0c\u5176\u4e2d\u5b58\u5728\u5927\u91cf\u5b98\u50da\u673a\u6784\uff0c\u533b\u751f\u548c\u8bca\u6240\u516c\u5f00\u6279\u8bc4\u8be5\u7cfb\u7edf\u529f\u80fd\u5931\u8c03\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"CAR-T-Zelltherapien\"><\/span>CAR-T \u7ec6\u80de\u7597\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u4e00\u822c\u53ef\u9000\u6b3e\uff0c\u4f46\u6bd4\u8f83\u590d\u6742<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"AMNOG_NUB-Verfahren\"><\/span>AMNOG \u548c NUB \u7a0b\u5e8f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>CAR-T \u5236\u5242\u6709 <strong>\u5148\u8fdb\u6cbb\u7597\u836f\u7269\u4ea7\u54c1\uff08ATMP\uff09<\/strong> \u5e76\u53d7\u5fb7\u56fd <strong>AMNOG \u7a0b\u5e8f<\/strong> (\u836f\u54c1\u5e02\u573a\u91cd\u7ec4\u6cd5\u300b\uff09\u3002\u8be5\u6cd5\u89c4\u5b9a<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fruhe_Nutzenbewertung_durch_den_G-BA\"><\/span>G-BA \u7684\u65e9\u671f\u6548\u76ca\u8bc4\u4f30<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u81ea 2011 \u5e74 1 \u6708 1 \u65e5\u8d77\uff0cG-BA \u7684\u6cd5\u5b9a\u4efb\u52a1\u662f\u5728\u6240\u6709\u542b\u6709\u65b0\u6d3b\u6027\u7269\u8d28\u7684\u65b0\u6388\u6743\u836f\u54c1\u8fdb\u5165\u5e02\u573a\u540e\u7acb\u5373\u8fdb\u884c\u6548\u76ca\u8bc4\u4f30\u3002.<br>\u6d4b\u8bd5\u65b0\u836f\u662f\u5426\u4f18\u4e8e\u4ee5\u524d\u7684\u6807\u51c6\u7597\u6cd5\uff0c\u5373\u6240\u8c13\u7684 <strong>\u9002\u5f53\u7684\u6bd4\u8f83\u7597\u6cd5<\/strong> - \u63d0\u4f9b\u4e86\u4f18\u52bf\u3002.<\/p>\n\n\n\n<p><strong>\u6cd5\u5f8b\u4f9d\u636e\uff1a<\/strong> <a href=\"https:\/\/www.gesetze-im-internet.de\/sgb_5\/__35a.html\" target=\"_blank\" rel=\"noopener\">\u00a7 \u300a\u5fb7\u56fd\u5211\u6cd5\u5178\u300b\u7b2c 35a \u6761\u7b2c V \u6b3e--\u8bc4\u4f30\u533b\u836f\u4ea7\u54c1\u7684\u76ca\u5904\uff08\u6cd5\u5f8b\u63aa\u8f9e\uff09<\/a><\/p>\n\n\n\n<p><strong>\u7a0b\u5e8f\u8bf4\u660e G-BA\uff1a<\/strong> <a href=\"https:\/\/www.g-ba.de\/themen\/arzneimittel\/arzneimittel-richtlinie-anlagen\/nutzenbewertung-35a\/\" target=\"_blank\" rel=\"noopener\">g-ba.de - \u6839\u636e SGB V \u00a7 35a \u8fdb\u884c\u7684 AMNOG \u6548\u76ca\u8bc4\u4f30<\/a><\/p>\n\n\n\n<p>\u6536\u76ca\u8bc4\u4f30\u7ed3\u679c\u662f GKV-Spitzenverband \u4e0e\u5236\u836f\u5546\u8fdb\u884c\u4ef7\u683c\u8c08\u5224\u7684\u51fa\u53d1\u70b9\u3002.<br>\u5fb7\u56fd\u836f\u54c1\u798f\u5229\u8bc4\u4f30\u6761\u4f8b\u300b\u548c\u300aG-BA \u7a0b\u5e8f\u6cd5\u300b\u7b2c 5 \u7ae0\u89c4\u5b9a\u4e86\u8bc4\u4f30\u9644\u52a0\u798f\u5229\u7684\u53ef\u80fd\u7c7b\u522b\u3002.<\/p>\n\n\n\n<p>\u56db\u7c7b\u989d\u5916\u798f\u5229\u662f<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u91cd\u8981<\/strong> \u989d\u5916\u798f\u5229<\/li>\n\n\n\n<li><strong>\u53ef\u89c2<\/strong> \u989d\u5916\u798f\u5229<\/li>\n\n\n\n<li><strong>\u8f83\u4f4e<\/strong> \u989d\u5916\u798f\u5229<\/li>\n\n\n\n<li><strong>\u65e0<\/strong> \u7ecf\u8bc1\u5b9e\u7684\u989d\u5916\u76ca\u5904<\/li>\n<\/ul>\n\n\n\n<p><strong>\u539f\u59cb\u63aa\u8f9e\u4e2d\u7684\u56db\u4e2a\u7c7b\u522b\uff1a<\/strong> <a href=\"https:\/\/www.g-ba.de\/themen\/arzneimittel\/arzneimittel-richtlinie-anlagen\/nutzenbewertung-35a\/zusatznutzen\/\" target=\"_blank\" rel=\"noopener\">g-ba.de - \u589e\u503c\u7c7b\u522b<\/a><\/p>\n\n\n\n<p><strong>\u7c7b\u522b\u7684\u6cd5\u5f8b\u4f9d\u636e\uff1a<\/strong> <a href=\"https:\/\/www.gesetze-im-internet.de\/am-nutzenv\/BJNR232400010.html\" target=\"_blank\" rel=\"noopener\">AM-NutzenV \u00a7 5 \u7b2c 7 \u6bb5 - \u300a\u836f\u54c1\u798f\u5229\u8bc4\u4f30\u6761\u4f8b\u300b\uff08\u6cd5\u5f8b\u63aa\u8f9e\uff09<\/a><\/p>\n\n\n\n<p><strong>\u5177\u4f53\u5b9e\u4f8b\uff1aYescarta\uff08CAR-T\uff09\u7684 G-BA \u7a0b\u5e8f\uff1a<\/strong> <a href=\"https:\/\/www.g-ba.de\/bewertungsverfahren\/nutzenbewertung\/406\/\" target=\"_blank\" rel=\"noopener\">g-ba.de - \u6548\u76ca\u8bc4\u4f30\u7a0b\u5e8f Axicabtagene-Ciloleucel<\/a><\/p>\n\n\n\n<p><strong>\u6240\u6709\u6b63\u5728\u8fdb\u884c\u548c\u5df2\u7ecf\u5b8c\u6210\u7684 G-BA \u8bc4\u4f30\u7a0b\u5e8f\uff1a<\/strong> <a href=\"https:\/\/www.g-ba.de\/bewertungsverfahren\/nutzenbewertung\/\" target=\"_blank\" rel=\"noopener\">g-ba.de - \u8bc4\u4f30\u7a0b\u5e8f\u6982\u8ff0<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Preisverhandlung_nach_%C2%A7_130b_SGB_V\"><\/span>\u6839\u636e \u00a7 130b SGB V \u8fdb\u884c\u4ef7\u683c\u8c08\u5224<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>GKV-Spitzenverband \u548c\u5236\u836f\u516c\u53f8\u4e00\u822c\u4f1a\u6839\u636e G-BA \u5bf9\u65b0\u836f\u54c1\u989d\u5916\u6536\u76ca\u7684\u51b3\u5b9a\uff0c\u5728 6 \u4e2a\u6708\u5185\u4e3e\u884c 4 \u6b21\u8c08\u5224\u4f1a\u8bae\uff0c\u534f\u5546\u6240\u8c13\u7684\u62a5\u9500\u91d1\u989d\u3002\u4ece\u836f\u54c1\u4e0a\u5e02\u540e\u7684\u7b2c\u4e03\u4e2a\u6708\u8d77\uff0c\u8be5\u4ef7\u683c\u5c06\u4f5c\u4e3a\u65b0\u7684\u5168\u56fd\u914d\u836f\u4ef7\u683c\uff0c\u9002\u7528\u4e8e\u6cd5\u5b9a\u533b\u7597\u4fdd\u9669\u3001\u79c1\u4eba\u4fdd\u9669\u548c\u81ea\u8d39\u8005\u3002.<\/p>\n\n\n\n<p><strong>\u6cd5\u5f8b\u4f9d\u636e\uff1a<\/strong> <a href=\"https:\/\/www.gesetze-im-internet.de\/sgb_5\/__130b.html\" target=\"_blank\" rel=\"noopener\">\u00a7 \u300a\u5211\u6cd5\u5178\u300b\u7b2c 130b \u6761\u7b2c V \u6b3e--\u507f\u8fd8\u91d1\u989d\u534f\u8bae\uff08\u6cd5\u5f8b\u63aa\u8f9e\uff09<\/a><\/p>\n\n\n\n<p><strong>\u7a0b\u5e8f\u8bf4\u660e GKV-Spitzenverband\uff1a<\/strong> <a href=\"https:\/\/www.gkv-spitzenverband.de\/krankenversicherung\/arzneimittel\/verhandlungen_nach_amnog\/rabatt_verhandlungen_nach_amnog.jsp\" target=\"_blank\" rel=\"noopener\">gkv-spitzenverband.de - \u6839\u636e\u300a\u5fb7\u56fd\u6c11\u6cd5\u5178\u300b\u7b2c\u4e94\u7f16\u7b2c 130b \u6761\u8fdb\u884c\u7684 AMNOG \u8c08\u5224<\/a><\/p>\n\n\n\n<p><strong>\u6240\u6709\u534f\u5546\u62a5\u9500\u91d1\u989d\u6982\u89c8\uff08\u5305\u62ec CAR-T \u4ea7\u54c1\uff09\uff1a<\/strong> <a href=\"https:\/\/www.gkv-spitzenverband.de\/krankenversicherung\/arzneimittel\/verhandlungen_nach_amnog\/ebv_130b\/ebv_nach_130b.jsp\" target=\"_blank\" rel=\"noopener\">gkv-spitzenverband.de - \u8865\u507f\u91d1\u989d\u534f\u8bae<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"NUB-Verfahren_fur_Krankenhauser\"><\/span>\u533b\u9662\u7684 NUB \u7a0b\u5e8f<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u7531\u4e8e CAR-T \u7597\u6cd5\u662f\u5728\u4f4f\u9662\u6cbb\u7597\u7684\u57fa\u7840\u4e0a\u8fdb\u884c\u7684\uff0c\u56e0\u6b64\u8bca\u6240\u4e5f\u5fc5\u987b\u9075\u5b88\u300a\u516c\u7ea6\u300b\u7684\u89c4\u5b9a\u3002 <strong>NUB \u7a0b\u5e8f<\/strong> (\u6839\u636e KHEntgG \u7b2c 6 (2) \u8282\u89c4\u5b9a\u7684\u65b0\u68c0\u67e5\u548c\u5904\u7406\u65b9\u6cd5\uff09\u3002.<\/p>\n\n\n\n<p>NUB \u7a0b\u5e8f\u5f25\u8865\u4e86\u6240\u8c13\u7684 \u201e\u521b\u65b0\u5dee\u8ddd\u201c\uff0c\u5373\u4e00\u79cd\u65b0\u7597\u6cd5\u5b8c\u5168\u7eb3\u5165 G-DRG \u7edf\u4e00\u8d39\u7387\u7cfb\u7edf\u4e4b\u524d\u901a\u5e38\u9700\u8981\u4e09\u5e74\u7684\u65f6\u95f4\u3002.<br>\u5728\u6b64\u671f\u95f4\uff0c\u533b\u9662\u53ef\u4ee5\u4e0e\u533b\u7597\u4fdd\u9669\u57fa\u91d1\u534f\u5546\u533b\u9662\u7279\u5b9a\u7684 NUB \u8d39\u7528\uff0c\u6761\u4ef6\u662f\u533b\u9662\u85aa\u916c\u5236\u5ea6\u7814\u7a76\u6240\uff08InEK\uff09\u5728\u5ba1\u67e5\u540e\u6388\u4e88 1 \u7ea7\u5730\u4f4d\u3002.<\/p>\n\n\n\n<p>\u533b\u9662\u5fc5\u987b\u5728\u6bcf\u5e74 10 \u6708 31 \u65e5\u524d\u5411 InEK \u63d0\u4ea4 NUB \u7533\u8bf7\u3002InEK \u5728\u6b21\u5e74 1 \u6708\u5e95\u524d\u516c\u5e03\u5ba1\u67e5\u7ed3\u679c\u3002.<\/p>\n\n\n\n<p>\u5bf9\u4e8e ATMP\uff08\u9ad8\u7ea7\u6cbb\u7597\u836f\u7269\u4ea7\u54c1\uff09\uff08\u5305\u62ec\u6240\u6709 CAR-T \u548c TCR-T \u4ea7\u54c1\uff09\uff0c\u9664\u975e\u5df2\u5728 10 \u6708 31 \u65e5\u524d\u63d0\u4ea4\u7533\u8bf7\uff0c\u5426\u5219\u7533\u8bf7\u622a\u6b62\u65e5\u671f\u5ef6\u957f\u81f3\u6bcf\u5e74\u7684 4 \u6708 30 \u65e5\u3002.<\/p>\n\n\n\n<p><strong>NUB \u7a0b\u5e8f\u5b98\u5458\uff08InEK\uff09\uff1a<\/strong> <a href=\"https:\/\/www.g-drg.de\/neue-untersuchungs-und-behandlungsmethoden-nub\/drg\" target=\"_blank\" rel=\"noopener\">g-drg.de - ATMP \u7684 NUB \u7a0b\u5e8f<\/a><\/p>\n\n\n\n<p><strong>NUB \u7a0b\u5e8f\uff08GKV-Spitzenverband\uff09\uff1a<\/strong> <a href=\"https:\/\/www.gkv-spitzenverband.de\/krankenversicherung\/krankenhaeuser\/drg_system\/neue_untersuchungs_und_behandlungsmethoden_nub\/neue_untersuchungs_und_behandlungsmethoden_nub.jsp\" target=\"_blank\" rel=\"noopener\">gkv-spitzenverband.de - \u533b\u9662\u4e2d\u7684 NUB<\/a><\/p>\n\n\n\n<p><strong>ATMP \u7279\u522b\u89c4\u5b9a\u7684\u8be6\u7ec6\u6d41\u7a0b\u8bf4\u660e\uff1a<\/strong> <a href=\"https:\/\/reimbursement.institute\/nub-antrag\/\" target=\"_blank\" rel=\"noopener\">\u507f\u8fd8\u673a\u6784 - NUB \u67e5\u8be2\u7a0b\u5e8f<\/a><\/p>\n\n\n\n<p><strong>AOK \u6982\u8ff0 NUB 2025\uff08\u9644\u73b0\u72b6\u6570\u636e\uff09\uff1a<\/strong> <a href=\"https:\/\/www.aok.de\/gp\/krankenhaus\/verguetung-drg\/nub\" target=\"_blank\" rel=\"noopener\">aok.de\/gp - NUB in somatics<\/a><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Die_Realitat_Einzelfallantrage_und_Burokratie\"><\/span>\u73b0\u5b9e\uff1a\u4e2a\u4eba\u7533\u8bf7\u548c\u5b98\u50da\u4e3b\u4e49<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5c3d\u7ba1\u6709\u534f\u5546\u597d\u7684\u62a5\u9500\u91d1\u989d\uff0c\u4f46\u8bca\u6240\u548c\u60a3\u8005\u7684\u5b9e\u9645\u64cd\u4f5c\u8981\u6bd4\u6b63\u5f0f\u89c4\u5b9a\u6240\u663e\u793a\u7684\u590d\u6742\u5f97\u591a\u3002.<\/p>\n\n\n\n<p>\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5404\u4e2d\u5fc3\u4e00\u822c\u90fd\u5fc5\u987b\u63d0\u4ea4\u4e2a\u4eba\u7533\u8bf7\uff0c\u4ee5\u83b7\u5f97\u6cd5\u5b9a\u533b\u7597\u4fdd\u9669\u7684\u8d39\u7528\u4fdd\u969c\u3002.<br>\u6ca1\u6709\u4e3a\u53c2\u52a0\u6cd5\u5b9a\u533b\u7597\u4fdd\u9669\u7684\u4eba\u63d0\u4f9b\u6807\u51c6\u5316\u7684\u81ea\u52a8\u8d39\u7528\u4fdd\u9669\u3002.<\/p>\n\n\n\n<p><strong>\u8d44\u6599\u6765\u6e90<\/strong> <a href=\"https:\/\/www.krebsinformationsdienst.de\/fachkreise\/nachrichten\/detail\/update-car-t-zell-therapie\" target=\"_blank\" rel=\"noopener\">DKFZ \u764c\u75c7\u4fe1\u606f\u670d\u52a1 - CAR-T \u6700\u65b0\u8fdb\u5c55\uff1a\u5355\u4e00\u7533\u8bf7\u7a0b\u5e8f\u548c\u6298\u6263\u534f\u8bae<\/a><\/p>\n\n\n\n<p>\u7531\u4e8e CAR-T \u4ea7\u54c1\u7684\u6210\u672c\u9ad8\u8fbe\u51e0\u5341\u4e07\u6b27\u5143\uff0c\u56e0\u6b64\u8bca\u6240\u5728\u5f00\u59cb\u6cbb\u7597\u524d\u5fc5\u987b\u83b7\u5f97\u6210\u672c\u8865\u507f\u3002LMU Klinikum M\u00fcnchen\u7684\u8d44\u6df1\u533b\u751fVeit B\u00fccklein\u535a\u58eb\u63cf\u8ff0\u4e86\u5176\u4e2d\u7684\u8270\u8f9b\uff1a\u201e\u6211\u4eec\u5fc5\u987b\u586b\u5199\u4e00\u4efd\u6838\u5bf9\u8868\uff0c\u5e76\u6c47\u7f16\u5f88\u591a\u5f88\u591a\u7684\u6587\u4ef6\uff0c\u4eceA\uff08\u533b\u751f\u4fe1\uff09\u5230Z\uff08\u6240\u6709\u7814\u7a76\u7ed3\u679c\u7684\u6c47\u7f16\uff09\u3002\u5b98\u65b9\u7a0b\u5e8f\u88ab\u79f0\u4e3a \u201c\u4e2a\u4eba\u8d39\u7528\u62a5\u9500\u7533\u8bf7\u7a0b\u5e8f\u201e\u3002.<\/p>\n\n\n\n<p><strong>\u8d44\u6599\u6765\u6e90<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapie-zukunftsversprechen-versus-burokratiemonster\/\" target=\"_blank\" rel=\"noopener\">\u533b\u836f\u4e8b\u5b9e - CAR-T\uff1a\u672a\u6765\u7684\u5e0c\u671b\u4e0e\u5b98\u50da\u4e3b\u4e49\u7684\u602a\u517d\uff08\u6155\u5c3c\u9ed1\u5927\u5b66\u533b\u5b66\u9662\uff0c2024 \u5e74 9 \u6708\uff09<\/a><\/p>\n\n\n\n<p>LMU Klinikum M\u00fcnchen\u7684CAR-T\u9879\u76ee\u8d1f\u8d23\u4ebaMarion Subklewe\u6559\u6388\u535a\u58eb\u603b\u7ed3\u4e86\u6279\u8bc4\u610f\u89c1\uff1a\u201e\u6211\u4eec\u4f7f\u7528\u7684\u662f\u5df2\u83b7\u6279\u51c6\u7684\u4ea7\u54c1\u3002\u6211\u4e0d\u660e\u767d\u4e3a\u4ec0\u4e48\u6bcf\u6b21\u90fd\u8981\u63d0\u4ea4\u4e00\u4efd\u6388\u6743\u4ea7\u54c1\u7684\u5355\u72ec\u7533\u8bf7\u201c\u3002\u76ee\u524d\uff0c\u62a5\u9500\u7a0b\u5e8f\u662f \u201e\u589e\u52a0\u8fdb\u5c55\u96be\u5ea6\u7684\u5de5\u5177\u201c\u3002.<\/p>\n\n\n\n<p><strong>\u8d44\u6599\u6765\u6e90<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapien-optimale-versorgung-sieht-anders-aus\/\" target=\"_blank\" rel=\"noopener\">\u533b\u836f\u4e8b\u5b9e--CAR-T\uff1a\u6700\u4f73\u62a4\u7406\u770b\u8d77\u6765\u4e0e\u4f17\u4e0d\u540c\uff082025 \u5e74 4 \u6708\uff09<\/a><\/p>\n\n\n\n<p>\u79d1\u9686\u5927\u5b66\u533b\u9662\u5185\u79d1 I \u8bca\u6240\u6240\u957f Michael Hallek \u535a\u58eb\u6559\u6388\u5efa\u8bae\uff0c\u89e3\u51b3\u65b9\u6848\u662f\u5c06 CAR-T \u7ec6\u80de\u7597\u6cd5\u7cfb\u7edf\u5730\u5206\u914d\u7ed9\u80fd\u591f\u8bb0\u5f55\u5176\u5de5\u4f5c\u5e76\u8bc1\u660e\u6210\u529f\u7684\u4e13\u4e1a\u4e2d\u5fc3\uff0c\u7136\u540e\u8ba9\u8fd9\u4e9b\u4e2d\u5fc3\u81ea\u7531\u5730\u505a\u51fa\u6cbb\u7597\u51b3\u5b9a\uff1a\u201e\u8fd9\u6837\u4f60\u5c31\u53ef\u4ee5\u5fd8\u8bb0\u5ba1\u67e5\u7a0b\u5e8f\uff0c\u56e0\u4e3a\u9664\u4e86\u6211\u4eec\uff0c\u8fd8\u6709\u8c01\u80fd\u5224\u65ad\u4e00\u79cd\u7597\u6cd5\u662f\u5426\u6b63\u786e\uff1f\u201c<\/p>\n\n\n\n<p><strong>\u8d44\u6599\u6765\u6e90<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapie-woran-es-noch-fehlt\/\" target=\"_blank\" rel=\"noopener\">\u533b\u836f\u4e8b\u5b9e--CAR-T\uff1a\u8fd8\u7f3a\u4ec0\u4e48\uff08\u79d1\u9686\u5927\u5b66\u533b\u9662\u6d3b\u52a8\uff0c2025 \u5e74 7 \u6708\uff09<\/a><\/p>\n\n\n\n<p>\u4ece\u5927\u5b66\u533b\u9662\u7684\u89d2\u5ea6\u6765\u770b\uff0c\u6838\u5fc3\u7684\u7ed3\u6784\u6027\u95ee\u9898\u662f\u7acb\u6cd5\u8005\u6ca1\u6709\u6d88\u9664\u836f\u54c1\u6388\u6743\u4e0e\u533b\u9662\u83b7\u5f97\u62a5\u9500\u4fdd\u8bc1\u4e4b\u95f4\u7684\u65f6\u95f4\u5dee\u3002\u5c31\u65b0\u7684\u7ec6\u80de\u548c\u57fa\u56e0\u7597\u6cd5\u800c\u8a00\uff0c\u533b\u9662\u7684\u8d22\u52a1\u98ce\u9669\u8fc7\u9ad8\uff0c\u65e0\u6cd5\u9884\u4ed8\u8d39\u7528\u3002.<\/p>\n\n\n\n<p><strong>\u8d44\u6599\u6765\u6e90<\/strong> <a href=\"https:\/\/www.uniklinika.de\/gesundheitspolitischethemen\/car-t-zelltherapie\/\" target=\"_blank\" rel=\"noopener\">Uniklinika.de - CAR-T \u7ec6\u80de\u7597\u6cd5\uff1a\u62a5\u9500\u4fdd\u969c\u9700\u6c42<\/a><\/p>\n\n\n\n<p>\u8fd9\u4e9b\u5ef6\u8bef\u9020\u6210\u7684\u533b\u7597\u540e\u679c\u662f\u53ef\u4ee5\u8861\u91cf\u7684\uff1a\u7b49\u5f85 CAR-T \u7ec6\u80de\u6cbb\u7597\u4e00\u4e2a\u6708\u53ef\u4f7f\u76f8\u5bf9\u6b7b\u4ea1\u7387\u589e\u52a0 6.2%\u3002\u83b7\u5f97 CAR-T \u6cbb\u7597\u7684\u4efb\u4f55\u5ef6\u8bef\u90fd\u4f1a\u76f4\u63a5\u5f71\u54cd\u6cbb\u7597\u7684\u6210\u529f\u7387\u3002.<\/p>\n\n\n\n<p><strong>\u8d44\u6599\u6765\u6e90<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapien-optimale-versorgung-sieht-anders-aus\/\" target=\"_blank\" rel=\"noopener\">Pharma-Fakten \/ IQVIA Institute - CAR-T\uff1a\u6700\u4f73\u6cbb\u7597\u770b\u8d77\u6765\u4e0e\u4f17\u4e0d\u540c\uff08\u53c2\u8003 IQVIA \u7814\u7a76\u62a5\u544a\uff09<\/a><\/p>\n\n\n\n<p>\u6b64\u5916\uff0c\u8fd8\u6709\u53e6\u4e00\u4e2a\u7ed3\u6784\u6027\u95ee\u9898\uff1a\u6709 160 \u591a\u5bb6\u533b\u9662\u63d0\u4ea4\u4e86 NUB \u7533\u8bf7\uff0c\u5e0c\u671b\u80fd\u591f\u63d0\u4f9b CAR-T \u7597\u6cd5\uff0c\u4f46\u6700\u521d\u53ea\u88ab\u6388\u4e88 NUB \u7b2c 4 \u7ea7\uff0c\u8fd9\u610f\u5473\u7740\u4f5c\u4e3a NUB \u534f\u8bae\u7684\u4e00\u90e8\u5206\uff0c\u793e\u4f1a\u4fdd\u9669\u5c40\u6ca1\u6709\u4e49\u52a1\u627f\u62c5\u8d39\u7528\u3002.<\/p>\n\n\n\n<p><strong>\u8d44\u6599\u6765\u6e90<\/strong> <a href=\"https:\/\/www.vdek.com\/magazin\/ausgaben\/2018-1112\/politik_car_t_zelltherapie.html\" target=\"_blank\" rel=\"noopener\">VDEK - \u80bf\u7624\u5b66\u7684\u9769\u547d\uff1aCAR-T \u7684 NUB \u72b6\u6001\u548c\u62a5\u9500\u95ee\u9898<\/a><\/p>\n\n\n\n<p>Subklewe \u6559\u6388\u63cf\u8ff0\u4e86\u533b\u9662\u65e5\u5e38\u751f\u6d3b\u4e2d\u4e00\u4e2a\u7279\u522b\u8352\u5510\u7684\u4f8b\u5b50\uff1a\u201e\u6211\u5fc5\u987b\u88ab\u544a\u77e5\uff0c\u80a0\u80c3\u75c5\u533b\u751f\u5fc5\u987b\u6bcf\u5929 24 \u5c0f\u65f6\u5728\u9644\u8fd1\uff0c\u5c3d\u7ba1\u6211\u5728\u8fc7\u53bb\u4e94\u5e74\u4e2d\u4ece\u672a\u9700\u8981\u8fc7\u80a0\u80c3\u75c5\u533b\u751f\u3002\u201c<br>\u67d0\u4e9b\u8d28\u91cf\u548c\u7ed3\u6784\u8981\u6c42\u662f\u5408\u7406\u7684\uff0c\u4f46\u4e0d\u5e94\u50cf\u73b0\u5728\u8fd9\u6837\u5931\u63a7\u3002.<\/p>\n\n\n\n<p><strong>\u8d44\u6599\u6765\u6e90<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapie-zukunftsversprechen-versus-burokratiemonster\/\" target=\"_blank\" rel=\"noopener\">\u533b\u836f\u4e8b\u5b9e - CAR-T\uff1a\u672a\u6765\u7684\u5e0c\u671b\u4e0e\u5b98\u50da\u4e3b\u4e49\u7684\u602a\u517d<\/a><\/p>\n\n\n\n<p><strong>\u5fb7\u56fd\u5408\u683c\u7684 CAR-T \u4e2d\u5fc3\u6982\u51b5<\/strong> (\u75c5\u4eba\u548c\u8f6c\u8bca\u533b\u751f\uff09\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.novartis.com\/de-de\/uebersicht-behandelnder-car-t-zentren-deutschland\" target=\"_blank\" rel=\"noopener\">\u8bfa\u534e - \u5fb7\u56fd CAR-T \u6cbb\u7597\u4e2d\u5fc3\u6982\u51b5\uff08Kymriah\uff09<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.lmu-klinikum.de\/aktuelles\/pressemitteilungen\/funf-jahre-car-t-zelltherapie-am-lmu-klinikum-nbsp\/c52167393f8351f2\" target=\"_blank\" rel=\"noopener\">LMU Klinikum M\u00fcnchen - CAR-T \u4e94\u5e74\uff1a\u8ba1\u5212\u4e0e\u8054\u7cfb\u65b9\u5f0f<\/a> <\/li>\n\n\n\n<li><a href=\"https:\/\/www.dkfz.de\/de\/presse\/pressemitteilungen\/2020\/dkfz-pm-20-40-CAR-T-Zell-Therapien-erhebliche-Kostenersparnis-moeglich.php\" target=\"_blank\" rel=\"noopener\">DKFZ - CAR T \u7ec6\u80de\u7597\u6cd5\uff1a\u901a\u8fc7\u5185\u90e8\u751f\u4ea7\u8282\u7ea6\u6210\u672c<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_%E2%80%9EPay-for-Outcome%E2%80%9C-Modell\"><\/span>\u6309\u6210\u679c\u4ed8\u8d39 \u201e\u6a21\u5f0f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p> (\u6309\u4e1a\u7ee9\u62a5\u9500)<\/p>\n\n\n\n<p>\u4f5c\u4e3a\u4e00\u79cd\u521b\u65b0\u7684\u4e34\u65f6\u89e3\u51b3\u65b9\u6848\uff0c\u4e2a\u4eba\u5065\u5eb7\u4fdd\u9669\u57fa\u91d1\u5df2\u540c\u610f\u6240\u8c13\u7684 <strong>\u7ee9\u6548\u4ed8\u8d39\u5408\u540c<\/strong> \u5173\u95ed\uff1a<\/p>\n\n\n\n<p>\u8bfa\u534e\u4e0e GWQ ServicePlus \u5c31 Kymriah \u8fbe\u6210\u4e86\u57fa\u4e8e\u7ee9\u6548\u7684\u62a5\u9500\u6a21\u5f0f\uff0c\u8fd9\u5728\u5fb7\u56fd\u5c1a\u5c5e\u9996\u4f8b\uff1a<br>\u5982\u679c\u60a3\u8005\u5728\u6cbb\u7597\u540e\u7684\u89c4\u5b9a\u65f6\u95f4\u5185\u6b7b\u4e8e\u8840\u764c\uff0c\u8bfa\u534e\u516c\u53f8\u5c06\u62a5\u9500\u90e8\u5206\u836f\u8d39\u3002. <br>\u7ed3\u679c\u53c2\u6570\u662f\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u7684\u5b58\u6d3b\u7387\u3002.<\/p>\n\n\n\n<p>\u8fd9\u79cd\u6a21\u5f0f\u5f00\u521b\u4e86\u4e00\u4e2a\u5148\u4f8b\uff1aTechniker Krankenkasse \u548c\u5176\u4ed6\u66ff\u4ee3\u533b\u7597\u4fdd\u9669\u57fa\u91d1\u4e5f\u7eb7\u7eb7\u6548\u4eff\uff0c\u7b7e\u8ba2\u4e86\u7c7b\u4f3c\u7684\u534f\u8bae\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Welche_CAR-T-Produkte_sind_in_Deutschland_erstattungsfahig\"><\/span>\u54ea\u4e9b CAR-T \u4ea7\u54c1\u5728\u5fb7\u56fd\u7b26\u5408\u62a5\u9500\u6761\u4ef6\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u4ea7\u54c1<\/th><th>\u8bf4\u660e<\/th><th>GKV \u72b6\u6001<\/th><\/tr><\/thead><tbody><tr><td><strong>\u57fa\u59c6\u91cc\u4e9a<\/strong> (Tisagenlecleucel\uff09<\/td><td>\u513f\u7ae5 B-ALL\u3001DLBCL\u3001FL<\/td><td>\u2705 \u534f\u5546\u9000\u6b3e\u91d1\u989d\uff08\u81ea 2019 \u5e74 9 \u6708\u8d77\uff09<\/td><\/tr><tr><td><strong>Yescarta<\/strong> (Axicabtagene-cel)<\/td><td>DLBCL\u3001PMBCL\u3001FL\u3001tFL<\/td><td>\u2705 \u534f\u5546\u9000\u6b3e\u91d1\u989d<\/td><\/tr><tr><td><strong>Tecartus<\/strong> (Brexucabtagene-cel)<\/td><td>MCL, \u6210\u4eba B-ALL<\/td><td>EMA \u6279\u51c6\uff1bNUB \u7a0b\u5e8f\u6b63\u5728\u8fdb\u884c\/\u5df2\u5b8c\u6210<\/td><\/tr><tr><td><strong>\u5e03\u96f7\u626c\u9f50<\/strong> (Lisocabtagene-cel)<\/td><td>DLBCL\u3001CLL\u3001FL<\/td><td>EMA \u6279\u51c6\uff1bNUB \u7a0b\u5e8f<\/td><\/tr><tr><td><strong>\u963f\u8d1d\u5361<\/strong> (Idecabtagene-cel)<\/td><td>\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/td><td>EMA \u6279\u51c6\uff1bNUB \u7a0b\u5e8f<\/td><\/tr><tr><td><strong>Carvykti<\/strong> (Ciltacabtagene-cel)<\/td><td>\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/td><td>EMA \u6279\u51c6\uff1bNUB \u7a0b\u5e8f<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>\u4efb\u4f55\u60c5\u51b5\u4e0b\u7684\u5b9e\u9645\u8981\u6c42<\/strong><br>\u6cbb\u7597\u4e2d\u5fc3\u5fc5\u987b<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7b26\u5408 G-BA \u7684 ATMP \u8d28\u91cf\u4fdd\u8bc1\u51c6\u5219<\/li>\n\n\n\n<li>\u83b7\u5f97 FACT\/JACIE \u8ba4\u8bc1<\/li>\n\n\n\n<li>\u5e76\u83b7\u5f97 CAR-T \u4e2d\u5fc3\u8ba4\u8bc1\u3002.<\/li>\n<\/ul>\n\n\n\n<p>\u53ea\u6709\u8fd9\u6837\uff0c\u624d\u80fd\u5546\u5b9a NUB \u8d39\u7528\u5e76\u5f00\u5177\u8d26\u5355\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kimmtrak_Tebentafusp_%E2%80%93_Sonderfall\"><\/span>Kimmtrak\uff08Tebentafusp\uff09--\u7279\u4f8b<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Kimmtrak \u4e0d\u662f\u4e00\u79cd\u7535\u6c60\u4ea7\u54c1\uff0c\u800c\u662f\u4e00\u79cd <strong>\u751f\u7269\u5236\u836f<\/strong> \u4e0e\u5176\u4ed6\u6297\u764c\u836f\u7269\u4e00\u6837\uff0c\u5b83\u4e5f\u9700\u8981\u901a\u8fc7\u5e38\u89c4\u7684 AMNOG \u7a0b\u5e8f\u3002\u8be5\u836f\u7269\u5728\u95e8\u8bca\u7ed9\u836f\uff0c\u4e00\u822c\u53ef\u901a\u8fc7\u5e38\u89c4\u7684\u80bf\u7624\u6536\u8d39\u9014\u5f84\u62a5\u9500\uff0c\u4f46\u4ec5\u9650\u4e8e\u5df2\u83b7\u6279\u51c6\u7684\u9002\u5e94\u75c7\uff08\u5982\uff1a\"\u8180\u80f1\u764c\"\u3001\"\u80be\u764c\"\u3001\"\u4e73\u817a\u764c\"\uff09\u3002<strong>HLA-A*02:01 \u9633\u6027\u8461\u8404\u819c\u9ed1\u8272\u7d20\u7624<\/strong>, \u7b2c\u4e00\u884c\uff09\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TIL-Therapie_Lifileucel_Amtagvi_%E2%80%93_In_Deutschland_derzeit_NICHT_erstattungsfahig\"><\/span>TIL\u7597\u6cd5\uff08Lifileucel\/Amtagvi\uff09--\u76ee\u524d\u5728\u5fb7\u56fd\u4e0d\u4e88\u62a5\u9500<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u8fd9\u662f\u5f53\u524d\u4e0e\u7f8e\u56fd\u76f8\u6bd4\u6700\u91cd\u8981\u7684\u4e0d\u540c\u4e4b\u5904\u3002.<\/p>\n\n\n\n<p>\u8be5\u516c\u53f8 <em>Iovance<\/em> \u4e8e 2025 \u5e74 7 \u6708 22 \u65e5\u64a4\u56de\u4e86\u5411\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u63d0\u4ea4\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\u3002. <\/p>\n\n\n\n<p>\u6b27\u6d32\u533b\u5b66\u7ba1\u7406\u5c40\uff08EMA\uff09\u5bf9\u4e3b\u8981\u7814\u7a76\u4e2d\u7684\u53cd\u5e94\u7387\u4ee5\u53ca\u4e25\u91cd\u7684\u5b89\u5168\u6027\u8868\u793a\u62c5\u5fe7\uff0c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u8be5\u7597\u6cd5\u4e0e\u6b7b\u4ea1\u6709\u5173\u3002.<br>\u6b64\u5916\uff0c\u5236\u9020\u5546\u8fd8\u7f3a\u4e4f\u8db3\u591f\u7684 GMP \u6587\u4ef6\u3002. <a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2025.43.16_suppl.TPS2673\" target=\"_blank\" rel=\"noreferrer noopener\">\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a<\/a><\/p>\n\n\n\n<p>\u76ee\u524d\uff0cIovance \u6b63\u5728\u4e0e\u6b27\u6d32\u533b\u5b66\u7ba1\u7406\u5c40\uff08EMA\uff09\u5171\u540c\u5236\u5b9a\u4e00\u9879\u65b0\u6218\u7565\uff0c\u4ee5\u83b7\u5f97 Amtagvi \u5728\u6b27\u76df\u7684\u4e0a\u5e02\u8bb8\u53ef\u3002\u5728\u82f1\u56fd\uff0c\u9884\u8ba1\u5c06\u4e8e2026\u5e74\u4e0a\u534a\u5e74\u83b7\u5f97\u6279\u51c6\uff1b\u6fb3\u5927\u5229\u4e9a\u5df2\u6388\u4e88\u4f18\u5148\u5ba1\u67e5\u6743\u3002. <a href=\"https:\/\/www.globenewswire.com\/de\/news-release\/2025\/03\/27\/3050384\/0\/en\/Immatics-Announces-Full-Year-2024-Financial-Results-and-Business-Update.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u5168\u7403\u65b0\u95fb\u901a\u8baf\u793e<\/a><\/p>\n\n\n\n<p><strong>\u5fb7\u56fd\u7684\u7ed3\u8bba\uff1a<\/strong> Lifileucel \u76ee\u524d\u5728\u6b27\u76df\u5e02\u573a\u9500\u552e <strong>\u672a\u83b7\u6279\u51c6\uff0c\u4e0d\u4e88\u62a5\u9500<\/strong>. .\u5e0c\u671b\u63a5\u53d7\u8fd9\u79cd\u6cbb\u7597\u7684\u60a3\u8005\u76ee\u524d\u5fc5\u987b\u5728\u7f8e\u56fd\u63a5\u53d7\u6cbb\u7597\uff0c\u8d39\u7528\u81ea\u7406\u6216\u4f5c\u4e3a\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e00\u90e8\u5206\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TCR-T-Therapien_Afami-cel_Tecelra_%E2%80%93_In_Europa_nicht_zugelassen\"><\/span>TCR-T \u7597\u6cd5\uff08Afami-cel \/ Tecelra\uff09--\u672a\u83b7\u6b27\u6d32\u6388\u6743<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Afamitresgene autoleucel\uff08Tecelra\uff09\u76ee\u524d\u662f <strong>\u4ec5\u5728\u7f8e\u56fd\u6388\u6743\u4f7f\u7528<\/strong> (\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff0c2024 \u5e74 8 \u6708\uff09\u3002EMA \u7533\u8bf7\u5c1a\u672a\u63d0\u4ea4\u3002.<\/p>\n\n\n\n<p>\u56e0\u6b64\uff0c\u5fb7\u56fd\u7684\u60c5\u51b5\u5982\u4e0b\uff1a\u4e0d\u80fd\u62a5\u9500\uff0c\u4e0d\u80fd\u6b63\u5e38\u4f7f\u7528\uff0c\u53ea\u80fd\u901a\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\u6216\u4e2a\u522b\u6cbb\u7597\u8bd5\u9a8c\uff08\u5982\u6d77\u5fb7\u5821 KiTZ \u7684 Mailo\uff09\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_tun_wenn_die_Kasse_ablehnt_Rechtliche_Moglichkeiten\"><\/span>\u5982\u679c\u4fdd\u9669\u516c\u53f8\u62d2\u7edd\uff0c\u8be5\u600e\u4e48\u529e\uff1f\u6cd5\u5f8b\u9009\u62e9<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u5982\u679c\u793e\u4f1a\u4fdd\u9669\u673a\u6784\u62d2\u7edd\u652f\u4ed8 EMA \u6388\u6743\u7597\u6cd5\u7684\u8d39\u7528\uff0c\u53ef\u91c7\u7528\u4ee5\u4e0b\u65b9\u6848\uff1a<\/p>\n\n\n\n<p><strong>\u53cd\u5bf9\uff08\u300a\u585e\u5c14\u7ef4\u4e9a\u5211\u6cd5\u5178\u300b\u7b2c 78 \u6761\u7b2c V \u6b3e\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5728\u62d2\u7edd\u540e 4 \u5468\u5185\u63d0\u4ea4\u4e66\u9762\u5f02\u8bae\u3002.<\/li>\n\n\n\n<li>\u8bca\u6240\u548c\u533b\u751f\u5e94\u9644\u4e0a\u8be6\u7ec6\u7684\u533b\u7597\u62a5\u544a\u3002.<\/li>\n<\/ul>\n\n\n\n<p><strong>\u793e\u4f1a\u6cd5\u5ead\u884c\u52a8<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5982\u679c\u4ecd\u672a\u505a\u51fa\u51b3\u5b9a\uff0c\u5219\u5411\u4e3b\u7ba1\u793e\u4f1a\u6cd5\u5ead\u63d0\u51fa\u7533\u8bc9\u3002.<\/li>\n\n\n\n<li>\u5982\u679c\u662f\u5371\u53ca\u751f\u547d\u7684\u75be\u75c5\uff0c\u5219\u9700\u8981 <strong>\u4e34\u65f6\u6cd5\u5f8b\u4fdd\u62a4<\/strong> \u53ef\u4ee5\u7533\u8bf7\u3001, <br>\u6cd5\u9662\u53ef\u4e34\u65f6\u547d\u4ee4\u627f\u62c5\u8d39\u7528\u3002.<\/li>\n<\/ul>\n\n\n\n<p><strong>\u00a7 \u300a\u5fb7\u56fd\u6c11\u6cd5\u5178\u300b\u7b2c 2(1a)\u6761\uff08\u5c3c\u53e4\u62c9\u65af\u51b3\u8bae\uff09<\/strong><\/p>\n\n\n\n<p>\u5728\u53d1\u751f\u5371\u53ca\u751f\u547d\u7684\u75be\u75c5\u548c\u7f3a\u4e4f\u6807\u51c6\u7597\u6cd5\u7684\u60c5\u51b5\u4e0b\uff0c\u5982\u679c\u6709\u6cbb\u6108\u6216\u660e\u663e\u7f13\u89e3\u7684\u91cd\u5927\u524d\u666f\uff0c\u88ab\u4fdd\u9669\u4eba\u6709\u6743\u63a5\u53d7\u975e\u6807\u51c6\u6388\u6743\u7597\u6cd5\u3002\u8fd9\u662f\u4e2a\u4eba\u6cbb\u7597\u5c1d\u8bd5\u7b49\u60c5\u51b5\u7684\u6838\u5fc3\u6cd5\u5f8b\u6587\u4e66\u3002.<\/p>\n\n\n\n<p><strong>\u91cd\u8981\u8d44\u6e90<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.g-ba.de\/themen\/arzneimittel\/arzneimittel-richtlinie-anlagen\/nutzenbewertung-131e\/\" target=\"_blank\" rel=\"noopener\">\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u7684 G-BA \u6548\u76ca\u8bc4\u4f30<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.dgho.de\/arbeitskreise\/a-g\/drg-gesundheitsoekonomie\/nub-2025\/nub-2025\" target=\"_blank\" rel=\"noopener\">DGHO NUB \u6a21\u677f 2025<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.krebsinformationsdienst.de\/fachkreise\/nachrichten\/detail\/update-car-t-zell-therapie\" target=\"_blank\" rel=\"noopener\">DKFZ \u764c\u75c7\u4fe1\u606f\u670d\u52a1 - CAR-T \u548c GKV<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapie-woran-es-noch-fehlt\/\" target=\"_blank\" rel=\"noopener\">\u533b\u836f\u4e8b\u5b9e\u5b98\u50da\u4e3b\u4e49\u95ee\u9898 CAR-T<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Osterreich\"><\/span>\u5965\u5730\u5229<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>\u5965\u5730\u5229\uff1a<\/strong> \u5728\u5965\u5730\u5229\uff0cCAR-T \u7ec6\u80de\u7597\u6cd5\u4e8e 2020 \u5e74 1 \u6708 1 \u65e5\u88ab\u7eb3\u5165 LKF \u670d\u52a1\u76ee\u5f55\uff08MEL22.30 \u7ec4\uff1a\u201e\u6539\u826f\u7ec6\u80de\u7684\u7ba1\u7406\u201c\uff09\uff0c\u56e0\u6b64\u6bd4\u5fb7\u56fd\u7684\u76d1\u7ba1\u66f4\u65e9\u3001\u66f4\u660e\u786e\u3002. <a href=\"https:\/\/www.clinicaltrialvanguard.com\/news\/t-knife-files-for-phase-1-trial-of-prame-t-cell-therapy\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u4e34\u5e8a\u8bd5\u9a8c\u5148\u950b<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Schweiz\"><\/span>\u745e\u58eb<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>\u745e\u58eb\uff1a<\/strong> \u5217\u5165 FOPH \u7684\u4e13\u79d1\u540d\u5355\u540e\uff0c\u901a\u8fc7 KVG\uff08\u533b\u7597\u4fdd\u9669\u6cd5\uff09\u62a5\u9500\uff1b\u5bf9\u4e8e EMA \u6279\u51c6\u7684 CAR-T \u4ea7\u54c1\uff0c\u539f\u5219\u4e0a\u53ef\u4ee5\u62a5\u9500\uff0c\u4f46\u4e5f\u8981\u8fdb\u884c\u4e2a\u6848\u8bc4\u4f30\u3002.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zusammenfassung\"><\/span>\u6458\u8981<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u6cbb\u7597<\/th><th>\u6b27\u76df\u6388\u6743<\/th><th>\u5fb7\u56fd SHI \u516c\u53f8\u62a5\u9500<\/th><\/tr><\/thead><tbody><tr><td>CAR-T \uff08Kymriah\u3001Yescarta\u3001Tecartus\u3001Breyanzi\u3001Abecma\u3001Carvykti\uff09<\/td><td>\u662f (EMA)<\/td><td>\u57fa\u672c\u4e0a\u662f--\u4f46\u8981\u901a\u8fc7\u4e2a\u6848\u7533\u8bf7\/NUB\uff0c\u5b98\u50da\u4f5c\u98ce\u76f8\u5f53\u4e25\u91cd<\/td><\/tr><tr><td>Kimmtrak (Tebentafusp)<\/td><td>\u662f (EMA)<\/td><td>\u662f\uff08AMNOG \u7a0b\u5e8f\uff0c\u95e8\u8bca\u75c5\u4eba\uff09<\/td><\/tr><tr><td>Lifileucel \/ Amtagvi (TIL)<\/td><td>\u5426\uff082025 \u5e74 7 \u6708\u64a4\u56de EMA \u7533\u8bf7\uff09<\/td><td>\u6ca1\u6709<\/td><\/tr><tr><td>Afami-cel \/ Tecelra\uff08TCR-T\uff09<\/td><td>\u5426\uff08\u4ec5\u9650\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff09<\/td><td>\u6ca1\u6709<\/td><\/tr><tr><td>PRAME-TCR \uff08IMA203\uff0c\u8bd5\u9a8c\u6027\uff09<\/td><td>\u5426\uff08\u7b2c 3 \u9636\u6bb5\uff09<\/td><td>\u5426 - \u4ec5\u901a\u8fc7\u53c2\u4e0e\u7814\u7a76<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u6838\u5fc3\u653f\u6cbb\u95ee\u9898\u4f9d\u7136\u5b58\u5728\uff1a\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5fb7\u56fd\u8fd8\u6ca1\u6709\u4e00\u4e2a\u771f\u6b63\u826f\u597d\u7684\u6cd5\u5f8b\u548c\u878d\u8d44\u6846\u67b6\u6765\u5feb\u901f\u3001\u53ef\u9760\u5730\u53cd\u6620\u8fd9\u4e9b\u521b\u65b0\u7597\u6cd5\u3002\u533b\u7597\u521b\u65b0\u7684\u6210\u672c\u53ef\u80fd\u9700\u8981\u6570\u5e74\u65f6\u95f4\u624d\u80fd\u5728\u6309\u75c5\u4f8b\u8ba1\u7b97\u7684\u7edf\u4e00\u8d39\u7387\u7cfb\u7edf\u4e2d\u5f97\u5230\u6b63\u786e\u53cd\u6620\u3002.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"PKV_und_Immunzelltherapie_%E2%80%93_Die_vollstandige_Rechtslage\"><\/span>PKV \u548c\u514d\u75ab\u7ec6\u80de\u7597\u6cd5--\u5b8c\u6574\u7684\u6cd5\u5f8b\u72b6\u51b5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u73b0\u72b6\uff1a2026 \u5e74 2 \u6708<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_rechtliche_Fundament_%C2%A7_192_VVG_und_MBKK_2009\"><\/span>\u6cd5\u5f8b\u57fa\u7840\uff1a\u00a7 192 VVG \u548c MB\/KK 2009<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5728\u533b\u7597\u8d39\u7528\u4fdd\u9669\u7684\u60c5\u51b5\u4e0b\uff0c\u4fdd\u9669\u4eba\u6709\u4e49\u52a1\u5728\u7ea6\u5b9a\u7684\u8303\u56f4\u5185\u8865\u507f\u56e0\u75be\u75c5\u6216\u4e8b\u6545\u540e\u679c\u800c\u4ea7\u751f\u7684\u533b\u7597\u5fc5\u9700\u7684\u6cbb\u7597\u8d39\u7528\u3002\u5982\u679c\u533b\u7597\u8d39\u7528\u6216\u5176\u4ed6\u4fdd\u9669\u91d1\u4e0e\u6240\u63d0\u4f9b\u7684\u4fdd\u9669\u91d1\u660e\u663e\u4e0d\u76f8\u79f0\uff0c\u5219\u4fdd\u9669\u4eba\u6ca1\u6709\u4e49\u52a1\u652f\u4ed8\u4fdd\u9669\u91d1\u3002.<\/p>\n\n\n\n<p><strong>\u6cd5\u5f8b\u6761\u6587 \u00a7 192 VVG\uff08\u5b8c\u6574\uff09\uff1a<\/strong> <a href=\"https:\/\/dejure.org\/gesetze\/VVG\/192.html\" target=\"_blank\" rel=\"noopener\">dejure.org - \u7b2c 192 VVG \u6761 \u4fdd\u9669\u4eba\u7684\u5178\u578b\u5408\u540c\u5229\u76ca<\/a><\/p>\n\n\n\n<p><strong>2009 \u5e74 MB\/KK \u5b98\u65b9\u6837\u672c\u6761\u4ef6\uff08PDF\uff0cPKV-Verband\uff09\uff1a<\/strong> <a href=\"https:\/\/www.pkv.de\/fileadmin\/user_upload\/PKV\/3_PDFs\/ABV_und_MB\/MB-KK.pdf\" target=\"_blank\" rel=\"noopener\">pkv.de - MB\/KK 2009 \u6837\u672c\u6761\u4ef6<\/a><\/p>\n\n\n\n<p>\u79c1\u4eba\u533b\u7597\u4fdd\u9669\u516c\u53f8\u63d0\u4f9b\u4fdd\u9669\u91d1\u7684\u4e49\u52a1\u4e3b\u8981\u53d6\u51b3\u4e8e\u5728\u4e2a\u522b\u60c5\u51b5\u4e0b\u6240\u9009\u62e9\u7684\u8d39\u7387\u4ee5\u53ca\u76f8\u5173\u7684\u8d39\u7387\u6761\u4ef6\u3002\u6839\u636e\u300a\u5fb7\u56fd\u533b\u7597\u4fdd\u9669\u6cd5\u300b\uff08VVG\uff09\u7b2c 192 \u6761\u7b2c 1 \u6b3e\u548c\u300a\u5fb7\u56fd\u533b\u7597\u4fdd\u9669\u6761\u4f8b\u300b\uff08MB\/KK\uff09\uff0c\u56e0\u75be\u75c5\u6216\u610f\u5916\u4e8b\u6545\u9020\u6210\u7684\u533b\u7597\u5fc5\u9700\u7684\u6cbb\u7597\u8d39\u7528\u53ef\u4ee5\u62a5\u9500\u3002.<\/p>\n\n\n\n<p><strong>\u6839\u636e \u00a7 192 VVG \u89e3\u91ca PKV \u798f\u5229\u4e49\u52a1\uff1a<\/strong> <a href=\"https:\/\/www.legal-plus.eu\/die-leistungspflicht-der-privaten-krankenversicherung-pkv-wann-und-wofuer-muss-die-pkv-zahlen\/\" target=\"_blank\" rel=\"noopener\">legal-plus.eu - PKV \u7684\u652f\u4ed8\u4e49\u52a1\uff1aPKV \u4f55\u65f6\u4ee5\u53ca\u652f\u4ed8\u4ec0\u4e48\uff1f<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_Schlusselbegriff_%E2%80%9EMedizinisch_notwendige_Heilbehandlung%E2%80%9C\"><\/span>\u5173\u952e\u672f\u8bed\uff1a\u201e\u533b\u7597\u5fc5\u9700\u7684\u6cbb\u7597\u201c<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u6839\u636e\u5df2\u786e\u7acb\u7684\u5224\u4f8b\u6cd5\u4ee5\u53ca MB\/KK \u548c VVG \u7b2c 192 \u6761\u7684\u6761\u4ef6\u8303\u672c\uff0c\u5982\u679c\u6839\u636e\u5ba2\u89c2\u7684\u533b\u5b66\u7ed3\u8bba\u548c\u77e5 \u8bc6\uff0c\u6cbb\u7597\u9002\u5408\u4e8e\u8bc6\u522b\u548c\u6cbb\u7597\u75be\u75c5\u3001\u9632\u6b62\u75be\u75c5\u6076\u5316\u6216\u51cf\u8f7b\u75c7\u72b6\uff0c\u5219\u5b58\u5728\u533b\u7597\u5fc5\u8981\u6027\u3002\u51b3\u5b9a\u6027\u56e0\u7d20\u662f\uff0c\u5728\u6cbb\u7597\u65f6\u6709\u8d44\u683c\u7684\u533b\u751f\u8ba4\u4e3a\uff0c\u6839\u636e\u516c\u8ba4\u7684\u79d1\u5b66\u6807\u51c6\uff0c\u8be5\u63aa\u65bd\u4f3c\u4e4e\u662f\u5fc5\u8981\u7684\u3002.<\/p>\n\n\n\n<p><strong>\u6cd5\u5f8b\u5206\u6790\uff1a\u79c1\u4eba\u533b\u7597\u4fdd\u9669\u4e2d\u533b\u7597\u5fc5\u8981\u6027\u7684\u5b9a\u4e49\uff1a<\/strong> <a href=\"https:\/\/kanzlei-neue-kraeme.de\/erstattung-kostenintensiver-behandlungsmassnahmen-in-der-pkv\/\" target=\"_blank\" rel=\"noopener\">kanzlei-neue-kraeme.de - \u79c1\u4eba\u533b\u7597\u4fdd\u9669\u4e2d\u8d39\u7528\u5bc6\u96c6\u578b\u6cbb\u7597\u63aa\u65bd\u7684\u62a5\u9500\u95ee\u9898<\/a><\/p>\n\n\n\n<p>\u9664\u4e86\u4f20\u7edf\u533b\u5b66\u8ba4\u53ef\u7684\u6cbb\u7597\u65b9\u6cd5\u5916\uff0c\u79c1\u4eba\u533b\u7597\u4fdd\u9669\u8fd8\u62a5\u9500\u5728\u5b9e\u8df5\u4e2d\u88ab\u8bc1\u660e\u540c\u6837\u6709\u6548\u6216\u6ca1\u6709\u66ff\u4ee3\u65b9\u6cd5\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u8fd9\u4e9b\u6cbb\u7597\u65b9\u6cd5\u4e5f\u53ef\u4ee5\u662f\u4e13\u5bb6\u8ba4\u4e3a\u6709\u7528\u7684\u65b0\u836f\u6216\u521b\u65b0\u8bca\u65ad\u7a0b\u5e8f\u548c\u6cbb\u7597\u65b9\u6cd5\u3002.<\/p>\n\n\n\n<p><strong>PKV \u534f\u4f1a\uff1a\u5173\u4e8e\u798f\u5229\u548c\u62a5\u9500\uff08\u5305\u62ec\u521b\u65b0\u7597\u6cd5\uff09\u7684\u5b98\u65b9\u89e3\u91ca\uff1a<\/strong> <a href=\"https:\/\/www.pkv.de\/wissen\/private-krankenversicherung\/leistungen-und-erstattung\/\" target=\"_blank\" rel=\"noopener\">pkv.de - \u79c1\u4eba\u533b\u7597\u4fdd\u9669\u7684\u798f\u5229\u548c\u62a5\u9500<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_Richtungsurteil_OLG_Frankfurt_29062022_%E2%80%93_Az_7_U_14021\"><\/span>\u91cc\u7a0b\u7891\u5f0f\u7684\u5224\u51b3\uff1a\u6cd5\u5170\u514b\u798f\u5730\u65b9\u6cd5\u9662\uff0c2022 \u5e74 6 \u6708 29 \u65e5 - \u7f16\u53f7 7 U 140\/21<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u8fd9\u662f\u5fb7\u56fd\u79c1\u4eba\u533b\u7597\u4fdd\u9669\u5bf9\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u62a5\u9500\u7684\u5173\u952e\u5224\u65ad\u3002.<\/p>\n\n\n\n<p><strong>\u6848\u4ef6\u4e8b\u5b9e<\/strong><br>\u4e00\u540d\u60a3\u8005\u88ab\u8bca\u65ad\u51fa\u60a3\u6709\u65e0\u6cd5\u624b\u672f\u7684\u80f0\u817a\u80bf\u7624\u3002\u5316\u7597\u5931\u8d25\u540e\uff0c\u4ed6\u51b3\u5b9a\u653e\u5f03\u6210\u529f\u9884\u540e\u8f83\u4f4e\u7684\u6807\u51c6\u59d1\u606f\u7597\u6cd5\uff0c\u8f6c\u800c\u9009\u62e9\u6811\u7a81\u72b6\u7ec6\u80de\u7597\u6cd5\u3002\u4ed6\u60f3\u5411\u79c1\u4eba\u533b\u7597\u4fdd\u9669\u516c\u53f8\u7d22\u8d54\u8d39\u7528\uff0c\u4f46\u4fdd\u9669\u516c\u53f8\u62d2\u7edd\u5168\u989d\u652f\u4ed8\u3002.<\/p>\n\n\n\n<p><strong>\u5224\u51b3<\/strong><br>\u6811\u7a81\u72b6\u7ec6\u80de\u7597\u6cd5\u662f\u79c1\u4eba\u533b\u7597\u4fdd\u9669\u516c\u53f8\u533b\u7597\u8d39\u7528\u6761\u4ef6\uff08MB\/KK 2009\uff09\u4e2d\u89c4\u5b9a\u7684\u4e00\u79cd\u533b\u7597\u624b\u6bb5\u3002\u5982\u679c\u4f20\u7edf\u7684\u4e00\u7ebf\u7597\u6cd5\u4e0d\u80fd\u4e3a\u7f79\u60a3\u5371\u53ca\u751f\u547d\u4e14\u65e0\u6cd5\u6cbb\u6108\u7684\u80bf\u7624\u7684\u60a3\u8005\u5e26\u6765\u9884\u671f\u7684\u6cbb\u7597\u6548\u679c\uff0c\u88ab\u4fdd\u9669\u4eba\u4e0d\u5fc5\u8f6c\u800c\u63a5\u53d7\u9884\u540e\u6548\u679c\u66f4\u5dee\u7684\u4e8c\u7ebf\u7597\u6cd5\u3002\u76f8\u53cd\uff0c\u5982\u679c\u5728\u6cbb\u7597\u65f6\uff0c\u4e00\u79cd\u65b0\u7684\u3001\u6709\u79d1\u5b66\u4f9d\u636e\u7684\u66ff\u4ee3\u7597\u6cd5\u6bd4\u6807\u51c6\u7684\u59d1\u606f\u6cbb\u7597\u66f4\u6709\u5e0c\u671b\u53d6\u5f97\u6210\u529f\uff0c\u90a3\u4e48\u4ed6\u4eec\u53ef\u4ee5\u8981\u6c42\u76f4\u63a5\u652f\u4ed8\u8fd9\u79cd\u7597\u6cd5\u7684\u8d39\u7528\u3002.<\/p>\n\n\n\n<p><strong>\u5bf9\u5224\u51b3\u7684\u5168\u9762\u8ba8\u8bba\uff08DATEV Magazin\uff09\uff1a<\/strong> <a href=\"https:\/\/www.datev-magazin.de\/nachrichten-steuern-recht\/recht\/private-krankenversicherung-muss-bei-inoperablem-tumor-nach-gescheiterter-chemotherapie-kosten-einer-alternativtherapie-mit-dendritischen-zellen-tragen-81762\" target=\"_blank\" rel=\"noopener\">datev-magazin.de - \u6cd5\u5170\u514b\u798f OLG\uff1aPKV \u5fc5\u987b\u627f\u62c5\u6811\u7a81\u72b6\u7ec6\u80de\u7597\u6cd5\u7684\u8d39\u7528<\/a><\/p>\n\n\n\n<p><strong>\u590d\u5ba1\u5224\u51b3\u5e76\u786e\u8ba4\u6cd5\u5f8b\u6548\u529b\uff082023 \u5e74 1 \u6708\uff09\uff1a<\/strong> <a href=\"https:\/\/transkript.de\/artikel\/2023\/krankenkasse-muss-zelltherapie-zahlen\/\" target=\"_blank\" rel=\"noopener\">transkript.de - \u5065\u5eb7\u4fdd\u9669\u516c\u53f8\u5fc5\u987b\u652f\u4ed8\u7ec6\u80de\u7597\u6cd5\u7684\u8d39\u7528\uff08\u5305\u62ec\u6cd5\u5f8b\u6548\u529b\u786e\u8ba4\u4e66\uff09<\/a><\/p>\n\n\n\n<p><strong>\u533b\u9662\u5224\u51b3\u5206\u6790\uff08IWW Verg\u00fctungsrecht\uff09\uff1a<\/strong> <a href=\"https:\/\/www.iww.de\/cb\/recht\/verguetungsrecht-schulmedizinische-behandlung-erfolglos-pkvmuss-kosten-der-alternativtherapie-tragen-f149155\" target=\"_blank\" rel=\"noopener\">iww.de - PKV \u5fc5\u987b\u627f\u62c5\u66ff\u4ee3\u7597\u6cd5\u7684\u8d39\u7528<\/a><\/p>\n\n\n\n<p><strong>Haufe: \u5224\u51b3\u4e66\u6458\u8981\uff1a<\/strong> <a href=\"https:\/\/www.haufe.de\/recht\/weitere-rechtsgebiete\/inoperabler-tumor-uebernahme-von-alternativtherapie-durch-pkv_216_571650.html\" target=\"_blank\" rel=\"noopener\">haufe.de - \u65e0\u6cd5\u624b\u672f\u7684\u80bf\u7624\uff1aPKV \u6db5\u76d6\u7684\u66ff\u4ee3\u7597\u6cd5<\/a><\/p>\n\n\n\n<p><strong>\u8be6\u7ec6\u5224\u51b3\u5206\u6790\uff08J\u00f6hnke &amp; Reichow Rechtsanw\u00e4lte\uff09\uff1a<\/strong> <a href=\"https:\/\/joehnke-reichow.de\/2024\/07\/17\/kostenerstattung-bei-einer-dendritischen-zellbehandlung-olg-frankfurt\/\" target=\"_blank\" rel=\"noopener\">joehnke-reichow.de - \u6811\u7a81\u72b6\u7ec6\u80de\u6cbb\u7597\u8d39\u7528\u62a5\u9500\uff0c\u6cd5\u5170\u514b\u798f OLG<\/a><\/p>\n\n\n\n<p><strong>\u6cd5\u5f8b\u6548\u529b\uff1a<\/strong> \u6839\u636e\u9ed1\u68ee\u5dde\u9ad8\u7b49\u6cd5\u9662\u7684\u89c4\u5b9a\uff0c\u63d0\u51fa\u4e0a\u8bc9\u7684\u671f\u9650\u5df2\u8fc7\uff0c\u8fd9\u610f\u5473\u7740\u8be5\u5224\u51b3\u81ea 2023 \u5e74 1 \u6708\u8d77\u5177\u6709\u6cd5\u5f8b\u7ea6\u675f\u529b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_%E2%80%9Eauffallige_Missverhaltnis%E2%80%9C_nach_%C2%A7_192_Abs_2_VVG_%E2%80%93_und_warum_es_bei_CAR-T_nicht_greift\"><\/span>VVG \u7b2c 192 \u6761\u7b2c 2 \u6b3e\u89c4\u5b9a\u7684 \u201e\u660e\u663e\u4e0d\u76f8\u79f0\u201c--\u4ee5\u53ca\u4e3a\u4f55\u4e0d\u9002\u7528\u4e8e CAR-T<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u4fdd\u9669\u4eba\u6709\u8d23\u4efb\u63d0\u51fa\u5e76\u8bc1\u660e\u5b58\u5728\u660e\u663e\u4e0d\u76f8\u79f0\u7684\u60c5\u51b5\u3002\u4eba\u4eec\u4e00\u81f4\u8ba4\u4e3a\uff0c\u6240\u63d0\u4f9b\u670d\u52a1\u7684\u901a\u5e38\u4ef7\u503c\u662f\u51b3\u5b9a\u6027\u7684\uff0c\u800c\u4e0d\u662f\u6700\u4f4e\u533b\u7597\u4ef7\u683c\u3002\u6839\u636e\u8054\u90a6\u6cd5\u9662\u5173\u4e8e\u9ad8\u5229\u8d37\u72af\u7f6a\u7684\u5224\u4f8b\u6cd5\uff0c\u5e02\u573a\u6bd4\u8f83\u662f\u786e\u5b9a\u5ba2\u89c2\u4ef7\u503c\u7684\u9002\u5f53\u624b\u6bb5\u3002.<\/p>\n\n\n\n<p>\u7531\u4e8e CAR-T \u7597\u6cd5\u5728\u5168\u7403\u7684\u5b9a\u4ef7\u6c34\u5e73\u76f8\u5f53\uff0825 \u4e07\u81f3 60 \u4e07\u6b27\u5143\uff09\uff0c\u56e0\u6b64\u901a\u8fc7\u56fd\u9645\u5e02\u573a\u6bd4\u8f83\uff0c\u201e\u660e\u663e\u5931\u8861 \u201c\u7684\u8bf4\u6cd5\u4e0d\u653b\u81ea\u7834\u3002.<\/p>\n\n\n\n<p><strong>\u6839\u636e VVG \u7b2c 192 \u6761\u7b2c 2 \u6b3e\u5bf9 \u201e\u660e\u663e\u4e0d\u76f8\u79f0 \u201c\u7684\u6cd5\u5f8b\u5206\u6790\uff1a<\/strong> <a href=\"https:\/\/www.kunzrechtsanwaelte.de\/aktuelles\/urteile\/versicherung-und-haftung\/krankenversicherung\" target=\"_blank\" rel=\"noopener\">kunzrechtsanwaelte.de - \u5173\u4e8e\u300a\u5fb7\u56fd\u6c11\u6cd5\u5178\u300b\u7b2c 192 \u6761\u7b2c 2 \u6b3e\u6240\u6307\u7684\u660e\u663e\u4e0d\u76f8\u79f0\u95ee\u9898<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_Voranfrageverfahren_nach_%C2%A7_192_Abs_8_VVG_%E2%80%93_der_wichtigste_praktische_Schritt\"><\/span>VVG \u7b2c 192 (8) \u6761\u89c4\u5b9a\u7684\u521d\u6b65\u8c03\u67e5\u7a0b\u5e8f--\u6700\u91cd\u8981\u7684\u5b9e\u9645\u6b65\u9aa4<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u6839\u636e\u300a\u5fb7\u56fd\u533b\u7597\u4fdd\u9669\u6cd5\u300b\u7b2c 192 (8) \u6761\u7684\u89c4\u5b9a\uff0c\u4e00\u65e6\u9884\u8ba1\u6cbb\u7597\u8d39\u7528\u5c06\u8d85\u8fc7 2000 \u6b27\u5143\uff0c\u88ab\u4fdd\u9669\u4eba\u5c31\u6709\u6743\u83b7\u5f97\u6709\u5173\u8d39\u7528\u627f\u8bfa\u7684\u4fe1\u606f\u3002\u5728\u63d0\u4ea4\u8d39\u7528\u4f30\u7b97\u540e 4 \u5468\u5185\uff0c\u4fdd\u9669\u516c\u53f8\u5fc5\u987b\u6279\u51c6\u6216\u62d2\u7edd\u8d39\u7528\u627f\u62c5\u3002.<\/p>\n\n\n\n<p>\u5982\u679c\u6ca1\u6709\u5728\u89c4\u5b9a\u671f\u9650\u5185\u63d0\u4f9b\u4fe1\u606f\uff0c\u4fdd\u9669\u4eba\u5c31\u4f1a\u8ba4\u4e3a\u9884\u671f\u7684\u533b\u7597\u662f\u5fc5\u8981\u7684\uff0c\u76f4\u5230\u76f8\u53cd\u7684 \u60c5\u51b5\u5f97\u5230\u8bc1\u5b9e\u3002\u8fd9 <strong>\u5fc5\u8981\u7684\u865a\u6784<\/strong> \u5728\u6ca1\u6709\u56de\u5e94\u7684\u60c5\u51b5\u4e0b\uff0c\u5bf9\u75c5\u4eba\u6765\u8bf4\u662f\u4e00\u79cd\u91cd\u8981\u7684\u4fdd\u62a4\u624b\u6bb5\u3002.<\/p>\n\n\n\n<p><strong>\u6cd5\u5f8b\u7b2c 192 \u6761\u7b2c 8 \u6b3e VVG\uff08\u4e8b\u5148\u8be2\u95ee\u7684\u4e49\u52a1\uff09\uff1a<\/strong> <a href=\"https:\/\/dejure.org\/gesetze\/VVG\/192.html\" target=\"_blank\" rel=\"noopener\">dejure.org - \u7b2c 192 (8) VVG \u6761<\/a><\/p>\n\n\n\n<p><strong>\u5b9e\u7528\u6307\u5357\uff1a\u5728\u8fdb\u884c\u6602\u8d35\u7684\u6cbb\u7597\u4e4b\u524d\uff0c\u5148\u5411 PKV \u8fdb\u884c\u521d\u6b65\u54a8\u8be2\uff1a<\/strong> <a href=\"https:\/\/www.pkv-inhalte.de\/pkv-bu-av-blog\/pkv-versichert-und-teure-behandlung-steht-bevor-wie-geht-man-richtig-vor\/\" target=\"_blank\" rel=\"noopener\">pkv-inhalte.de - PKV \u4fdd\u9669\u548c\u6602\u8d35\u7684\u6cbb\u7597\uff1a\u4ec0\u4e48\u662f\u6b63\u786e\u7684\u65b9\u6cd5\uff1f<\/a><\/p>\n\n\n\n<p><strong>\u9519\u8bef\u6216\u7f3a\u5931 PKV \u4fe1\u606f\u7684\u6cd5\u5f8b\u540e\u679c\uff1a<\/strong> <a href=\"https:\/\/www.versicherungsrechtsiegen.de\/krankenhauskosten-zusatzversicherung-kostenerstattung-fuer-aufenthalt-in-privatklinik\/\" target=\"_blank\" rel=\"noopener\">versicherungsrechtsiegen.de - \u8d39\u7528\u627f\u8bfa\u548c\u300a\u5fb7\u56fd\u6c11\u4e8b\u8bc9\u8bbc\u6cd5\u5178\u300b\u7b2c 192 \u6761\u7b2c 8 \u6b3e\u5728\u5b9e\u8df5\u4e2d\u7684\u5e94\u7528<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bei_Ablehnung_Rechtsmittel_und_Klage\"><\/span>\u5982\u679c\u88ab\u62d2\u7edd\uff1a\u4e0a\u8bc9\u548c\u6cd5\u5f8b\u8bc9\u8bbc<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u62a5\u9500\u95ee\u9898\u7531 VVG \u7b2c 192 \u6761\u3001MB\/KK \u6761\u4ef6\u8303\u672c\u548c\u4e2a\u522b\u5173\u7a0e\u6761\u6b3e\u7684\u76f8\u4e92\u4f5c\u7528\u51b3\u5b9a\u3002\u51b3\u5b9a\u6027\u56e0\u7d20\u662f\u6cbb\u7597\u662f\u5426\u56e0\u75be\u75c5\u800c\u8fdb\u884c\uff0c\u4ee5\u53ca\u662f\u5426\u4e3a\u533b\u7597\u6240\u5fc5\u9700\u3002.<\/p>\n\n\n\n<p>\u5982\u679c\u7533\u8bf7\u88ab PKV \u62d2\u7edd\uff0c\u53ef\u4ee5\u9009\u62e9\u4ee5\u4e0b\u65b9\u6848\uff1a<\/p>\n\n\n\n<p><strong>\u53cd\u5bf9\u5e76\u63d0\u4f9b\u5b8c\u6574\u7684\u533b\u7597\u6863\u6848<\/strong> (\u533b\u5b66\u610f\u89c1\u3001\u80bf\u7624\u59d4\u5458\u4f1a\u534f\u8bae\u3001\u56fd\u9645\u7814\u7a76\u60c5\u51b5\u3001\u6210\u672c\u4f30\u7b97\uff09\u3002<\/p>\n\n\n\n<p><strong>\u6c11\u4e8b\u6cd5\u5ead\u8bc9\u8bbc<\/strong> (\u5728\u6025\u9700\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u7533\u8bf7\u4e34\u65f6\u7981\u4ee4\uff08\u4e0d\u662f\u793e\u4f1a\u6cd5\u5ead\uff0c\u8fd9\u662f\u4e0e\u6cd5\u5b9a\u533b\u7597\u4fdd\u9669\u7684\u533a\u522b\uff09\u3002<\/p>\n\n\n\n<p><strong>\u5b8c\u6574\u6307\u5357\uff1a\u5bf9 PKV \u62d2\u7edd\u3001\u5f02\u8bae\u548c\u6cd5\u5f8b\u884c\u52a8\u63d0\u51fa\u5f02\u8bae\uff1a<\/strong> <a href=\"https:\/\/kanzlei-neue-kraeme.de\/erstattung-kostenintensiver-behandlungsmassnahmen-in-der-pkv\/\" target=\"_blank\" rel=\"noopener\">kanzlei-neue-kraeme.de - \u79c1\u4eba\u533b\u7597\u4fdd\u9669\u5bf9\u8d39\u7528\u9ad8\u6602\u7684\u6cbb\u7597\u8fdb\u884c\u62a5\u9500<\/a><\/p>\n\n\n\n<p><strong>\u62d2\u7edd\u79c1\u4eba\u533b\u7597\u4fdd\u9669\u548c\u798f\u5229\uff1a\u6cd5\u5f8b\u6b65\u9aa4\u4e00\u89c8\uff1a<\/strong> <a href=\"https:\/\/kva-plus.de\/ablehnung-der-kostenuebernahme-durch-die-pkv-und-beihilfe\/\" target=\"_blank\" rel=\"noopener\">kva-plus.de - \u62d2\u7edd\u79c1\u4eba\u533b\u7597\u4fdd\u9669\u548c\u56fd\u5bb6\u8865\u52a9\u7684\u8d39\u7528\u8303\u56f4<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u9605\u8bfb\u65f6\u95f4<\/span> <span class=\"rt-time\"> 20<\/span> <span class=\"rt-label rt-postfix\">\u5206\u949f<\/span><\/span>Das Immunsystem &#8211; was macht das? Das Immunsystem unterh\u00e4lt eine ganze Armee von Kundschaftern, K\u00e4mpfern (T-Zellen) und Helfern. Sie patrouillieren st\u00e4ndig durch den K\u00f6rper und suchen nach Eindringlingen, wie Bakterien, Viren, aber auch wild gewordene k\u00f6rpereigene Zellen &#8211; Krebszellen. Normalerweise werden solch randalierende Zellen von den W\u00e4chtern des immunsystems schnell entdeckt, abget\u00f6tet, deren \u00dcberreste abtransportiert&hellip;&nbsp;<a href=\"https:\/\/csiag.de\/zh\/blog\/2026\/02\/19\/immunzelltherapie\/\" rel=\"bookmark\">\u9605\u8bfb\u66f4\u591a \u00bb<span class=\"screen-reader-text\">\u514d\u75ab\u7ec6\u80de\u7597\u6cd5<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[5584,1078,354],"tags":[],"class_list":["post-12789","post","type-post","status-publish","format-standard","hentry","category-krebs","category-medizin","category-medizin-gesundheit"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.de\/zh\/wp-json\/wp\/v2\/posts\/12789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.de\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.de\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.de\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.de\/zh\/wp-json\/wp\/v2\/comments?post=12789"}],"version-history":[{"count":0,"href":"https:\/\/csiag.de\/zh\/wp-json\/wp\/v2\/posts\/12789\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.de\/zh\/wp-json\/wp\/v2\/media?parent=12789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.de\/zh\/wp-json\/wp\/v2\/categories?post=12789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.de\/zh\/wp-json\/wp\/v2\/tags?post=12789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}