{"id":10036,"date":"2025-06-02T19:05:44","date_gmt":"2025-06-02T19:05:44","guid":{"rendered":"https:\/\/csiag.de\/?p=10036"},"modified":"2025-06-03T20:37:17","modified_gmt":"2025-06-03T20:37:17","slug":"toksisiteten-til-lnp-avhengig-av-lengden-pa-pinnekjeden","status":"publish","type":"post","link":"https:\/\/csiag.de\/nb\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/","title":{"rendered":"Toksisiteten til LNP avhenger av lengden p\u00e5 PEG-kjeden"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Innholdsfortegnelse<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.de\/nb\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Welche_LNPs_wurden_verwendet\" >Hvilke LNP-er ble brukt?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.de\/nb\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Toxizitat_wurde_nicht_durch_Studien_uberpruft\" >Toksisitet har ikke blitt verifisert av studier<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.de\/nb\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Akkumulation_in_der_Leber\" >Akkumulering i leveren<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.de\/nb\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Der_Weg_in_die_Leber_und_die_Lange_der_Kette\" >Veien inn i leveren og lengden p\u00e5 kjeden<\/a><\/li><\/ul><\/nav><\/div>\n\n<p class=\"wp-block-paragraph\">Jo kortere PEG-kjeden (polyetylenglykol) er, desto h\u00f8yere er toksisiteten til LNP. BioNTech forklarer dette i sin <a href=\"https:\/\/www.mdpi.com\/2227-9059\/9\/5\/530\" target=\"_blank\" rel=\"noreferrer noopener\">Utgivelse<\/a> \"Non-Immunotherapy Application of LNP-mRNA: Maximising Efficacy and Safety\" fra 10.05.2021, riktignok formulert - noe - annerledes: \"Maximising Efficacy\".<br>Toksisiteten er basert p\u00e5 det faktum at alle de tre ioniserbare kationiske lipidene ikke er biologisk nedbrytbare, og at den uunng\u00e5elige akkumuleringen av dem i kroppen har cytotoksiske konsekvenser.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Welche_LNPs_wurden_verwendet\"><\/span>Hvilke LNP-er ble brukt?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Pfizer<\/em> \/ <em>BioNTech<\/em> - BNT162b2 - <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0315<\/a> (ioniserbar) og <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0159\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0159<\/a> (PEGylerte)<br><em>Moderna<\/em> - <a href=\"https:\/\/www.echelon-inc.com\/product\/sm-102\/\" target=\"_blank\" rel=\"noreferrer noopener\">SM-102<\/a> (ioniserbar) og <a href=\"https:\/\/www.echelon-inc.com\/product\/dmg-peg-2000\/\" target=\"_blank\" rel=\"noreferrer noopener\">PEG2000-DMG<\/a> (PEGylerte)<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"562\" src=\"https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-1024x562.png\" alt=\"\" class=\"wp-image-10045\" srcset=\"https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-1024x562.png 1024w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-300x165.png 300w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-768x421.png 768w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-18x10.png 18w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image.png 1456w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">For alle lipidene som er nevnt ovenfor, har produsentene (f.eks. <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/#tab-description\" target=\"_blank\" rel=\"noreferrer noopener\">Echelon Biosciences<\/a>) \"... Dette er et produkt av reagenskvalitet, kun til forskningsbruk.\"<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Toxizitat_wurde_nicht_durch_Studien_uberpruft\"><\/span>Toksisitet har ikke blitt verifisert av studier<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">I henhold til <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Utgivelse<\/a> \"Nonclinical Evaluation Report BNT 162b2 mRNA COVID-19 vaccine COMIRNATY\u2122\" fra den australske regjeringen - Department of Health fra januar 2021 kan leses p\u00e5 side 11: \"Toksisiteten til LNP-formuleringen eller de nye hjelpestoffene alene ble ikke spesifikt studert.\"<br>Det er med andre ord ikke utf\u00f8rt noen toksisitetsstudier p\u00e5 bruken og effekten av de nye hjelpestoffene i LNP som er nevnt ovenfor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Akkumulation_in_der_Leber\"><\/span>Akkumulering i leveren<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Mange legemidler metaboliseres helt eller delvis i leveren og g\u00e5r over i blodbanen. Det ovennevnte hjelpestoffet ALC-315 akkumuleres ogs\u00e5 i leveren, som det fremg\u00e5r av <a href=\"https:\/\/www.judicialwatch.org\/wp-content\/uploads\/2022\/03\/JW-v-HHS-prod-3-02418.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Delvis svar p\u00e5 sp\u00f8rsm\u00e5l nr. 2021-4379<\/a> under Freedom of Information Act (FOIA), som er gjenstand for klagen i Judicial Watch, Inc. v. U.S. Department of Health and Human Services (21-cv-2418), som for tiden er til behandling i U.S. District Court for the District of Columbia, p\u00e5 side 16 av 466:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"542\" src=\"https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png\" alt=\"\" class=\"wp-image-10054\" srcset=\"https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png 1024w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-3-300x159.png 300w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-3-768x407.png 768w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-3-18x10.png 18w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-3.png 1212w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Ogs\u00e5 nevnt p\u00e5 side 45 i ovennevnte rapport. <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noopener\">Rapporter<\/a>:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"55\" src=\"https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png\" alt=\"\" class=\"wp-image-10060\" srcset=\"https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png 1024w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-4-300x16.png 300w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-4-768x42.png 768w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-4-18x1.png 18w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-4.png 1218w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">P\u00e5 side 46 skisseres en rent teoretisk hypotetisk metabolsk vei basert p\u00e5 in vitro-fors\u00f8k, selv om denne ikke er verifisert hos mennesker.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mens <a href=\"https:\/\/www.statnews.com\/2017\/01\/10\/moderna-trouble-mrna\/\" target=\"_blank\" rel=\"noreferrer noopener\">Moderna<\/a> avbr\u00f8t ALC-0315 p\u00e5 grunn av leverinkompatibilitet og utviklet SM-plattformen selv (ALC-0315 hadde vist seg \u00e5 v\u00e6re for giftig for genterapi av leversykdommen Crigler-Najjjar syndrom, slik at den dav\u00e6rende forskningspartneren <em>Alexion<\/em> stoppet studien av sikkerhetsmessige \u00e5rsaker), fortsetter BioNTech \/ Pfizer \u00e5 bruke dem mot bedre vitende.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_Weg_in_die_Leber_und_die_Lange_der_Kette\"><\/span>Veien inn i leveren og lengden p\u00e5 kjeden<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">...vil bli videref\u00f8rt...<\/p>","protected":false},"excerpt":{"rendered":"<p>Jo kortere PEG-kjeden (polyetylenglykol) er, desto h\u00f8yere er toksisiteten til LNP. BioNTech forklarer dette i publikasjonen \"Non-Immunotherapy Application of LNP-mRNA: Maximising Efficacy and Safety\" fra 10.05.2021, riktignok med en - noe - annen formulering: \"Maximising Efficacy\" Toksisiteten er basert p\u00e5 at alle de tre ioniserbare kationiske lipidene ikke er biologisk nedbrytbare, og toksisiteten er derfor...&nbsp;<a href=\"https:\/\/csiag.de\/nb\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/\" rel=\"bookmark\">Les mer \"<span class=\"screen-reader-text\">Toksisiteten til LNP avhenger av lengden p\u00e5 PEG-kjeden<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[628,316,1078],"tags":[5067,5066,5074,22,36,5080,5079,5069,5075,5071,4812,105,5073,5077,5070,5072,23,5076,5078,44],"class_list":["post-10036","post","type-post","status-publish","format-standard","hentry","category-corona","category-corona-blog","category-medizin","tag-alc-159","tag-alc-315","tag-alnylam","tag-biontech","tag-bnt162b2","tag-cholesterol","tag-dlin-mc3-dma","tag-dmg-peg2000","tag-elasomeran","tag-ionisierbar","tag-lnp","tag-moderna","tag-patisiran","tag-peg-lipid","tag-peg2000-dmg","tag-pegyliert","tag-pfizer","tag-phosholipid","tag-sterol","tag-tozinameran"],"acf":[],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.de\/nb\/wp-json\/wp\/v2\/posts\/10036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.de\/nb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.de\/nb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.de\/nb\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.de\/nb\/wp-json\/wp\/v2\/comments?post=10036"}],"version-history":[{"count":0,"href":"https:\/\/csiag.de\/nb\/wp-json\/wp\/v2\/posts\/10036\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.de\/nb\/wp-json\/wp\/v2\/media?parent=10036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.de\/nb\/wp-json\/wp\/v2\/categories?post=10036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.de\/nb\/wp-json\/wp\/v2\/tags?post=10036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}