{"id":10036,"date":"2025-06-02T19:05:44","date_gmt":"2025-06-02T19:05:44","guid":{"rendered":"https:\/\/csiag.de\/?p=10036"},"modified":"2025-06-03T20:37:17","modified_gmt":"2025-06-03T20:37:17","slug":"toxicite-de-lip-en-fonction-de-la-longueur-de-la-chaine-de-peg","status":"publish","type":"post","link":"https:\/\/csiag.de\/fr\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/","title":{"rendered":"Toxicit\u00e9 des LNP en fonction de la longueur de la cha\u00eene PEG"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table des mati\u00e8res<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.de\/fr\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Welche_LNPs_wurden_verwendet\" >Quels LNP ont \u00e9t\u00e9 utilis\u00e9s ?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.de\/fr\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Toxizitat_wurde_nicht_durch_Studien_uberpruft\" >La toxicit\u00e9 n'a pas \u00e9t\u00e9 v\u00e9rifi\u00e9e par des \u00e9tudes<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.de\/fr\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Akkumulation_in_der_Leber\" >Accumulation dans le foie<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.de\/fr\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Der_Weg_in_die_Leber_und_die_Lange_der_Kette\" >Le chemin vers le foie et la longueur de la cha\u00eene<\/a><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Temps de lecture<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">minutes<\/span><\/span>\n<p>Plus la cha\u00eene de PEG (poly\u00e9thyl\u00e8ne glycol) est courte, plus la toxicit\u00e9 des LNP est \u00e9lev\u00e9e. C'est ce qu'explique BioNTech dans son <a href=\"https:\/\/www.mdpi.com\/2227-9059\/9\/5\/530\" target=\"_blank\" rel=\"noreferrer noopener\">publication<\/a> \"Non-Immunotherapy Application of LNP-mRNA : Maximizing Efficacy and Safety\" du 10.05.2021, m\u00eame si la formulation est - l\u00e9g\u00e8rement - diff\u00e9rente : \"Maximizing Efficacy\".<br>La toxicit\u00e9 est due au fait que les trois lipides cationiques ionisables ne sont pas biod\u00e9gradables et que leur accumulation dans l'organisme, qui est donc in\u00e9vitable, a des cons\u00e9quences cytotoxiques.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Welche_LNPs_wurden_verwendet\"><\/span>Quels LNP ont \u00e9t\u00e9 utilis\u00e9s ?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><em>Pfizer<\/em> \/ <em>BioNTech<\/em> - BNT162b2 - <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0315<\/a> (ionisable) et <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0159\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0159<\/a> (PEGyl\u00e9e)<br><em>Moderne<\/em> - <a href=\"https:\/\/www.echelon-inc.com\/product\/sm-102\/\" target=\"_blank\" rel=\"noreferrer noopener\">SM-102<\/a> (ionisable) et <a href=\"https:\/\/www.echelon-inc.com\/product\/dmg-peg-2000\/\" target=\"_blank\" rel=\"noreferrer noopener\">PEG2000-DMG<\/a> (PEGyl\u00e9e)<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"562\" src=\"https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-1024x562.png\" alt=\"\" class=\"wp-image-10045\" srcset=\"https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-1024x562.png 1024w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-300x165.png 300w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-768x421.png 768w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-18x10.png 18w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image.png 1456w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p>Pour tous les lipides susmentionn\u00e9s, les fabricants (par ex. <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/#tab-description\" target=\"_blank\" rel=\"noreferrer noopener\">Echelon Biosciences<\/a>) \"... Ceci est un produit de qualit\u00e9 r\u00e9active, \u00e0 usage de recherche uniquement\".<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Toxizitat_wurde_nicht_durch_Studien_uberpruft\"><\/span>La toxicit\u00e9 n'a pas \u00e9t\u00e9 v\u00e9rifi\u00e9e par des \u00e9tudes<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Selon la <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Publication<\/a> \"Nonclinical Evaluation Report BNT 162b2 mRNA COVID-19 vaccine COMIRNATY\u2122\" du gouvernement australien - minist\u00e8re de la Sant\u00e9 de janvier 2021, on peut lire \u00e0 la page 11 : \"The toxicity of LNP formulation or the novel excipients alone was not specifically studied\".<br>En d'autres termes, aucune \u00e9tude de toxicit\u00e9 n'a \u00e9t\u00e9 men\u00e9e sur l'utilisation et les effets des nouveaux auxiliaires LNP mentionn\u00e9s ci-dessus.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Akkumulation_in_der_Leber\"><\/span>Accumulation dans le foie<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>De nombreux m\u00e9dicaments passent dans la circulation sanguine apr\u00e8s avoir \u00e9t\u00e9 partiellement ou totalement m\u00e9tabolis\u00e9s par le foie. Ainsi, l'excipient ALC-315 susmentionn\u00e9 s'accumule \u00e9galement dans le foie, comme le montre entre autres la <a href=\"https:\/\/www.judicialwatch.org\/wp-content\/uploads\/2022\/03\/JW-v-HHS-prod-3-02418.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">R\u00e9ponse partielle \u00e0 la question n\u00b0 2021-4379<\/a> en vertu du Freedom of Information Act (FOIA), qui fait l'objet de la plainte dans l'affaire Judicial Watch, Inc. contre le minist\u00e8re am\u00e9ricain de la Sant\u00e9 (21-cv-2418), actuellement pendante devant le tribunal de district am\u00e9ricain pour le District de Columbia, est indiqu\u00e9 \u00e0 la page 16 sur 466 :<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"542\" src=\"https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png\" alt=\"\" class=\"wp-image-10054\" srcset=\"https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png 1024w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-3-300x159.png 300w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-3-768x407.png 768w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-3-18x10.png 18w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-3.png 1212w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u00c9galement mentionn\u00e9 \u00e0 la page 45 du rapport susmentionn\u00e9. <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noopener\">Rapports<\/a>:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"55\" src=\"https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png\" alt=\"\" class=\"wp-image-10060\" srcset=\"https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png 1024w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-4-300x16.png 300w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-4-768x42.png 768w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-4-18x1.png 18w, https:\/\/csiag.de\/wp-content\/uploads\/2025\/06\/image-4.png 1218w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>A la page 46, la voie m\u00e9tabolique suppos\u00e9e de mani\u00e8re purement th\u00e9orique est esquiss\u00e9e sur la base d'exp\u00e9riences in vitro, mais elle n'a pas \u00e9t\u00e9 v\u00e9rifi\u00e9e chez l'homme.<\/p>\n\n\n\n<p>Alors que <a href=\"https:\/\/www.statnews.com\/2017\/01\/10\/moderna-trouble-mrna\/\" target=\"_blank\" rel=\"noreferrer noopener\">Moderne<\/a> s'est s\u00e9par\u00e9e de l'ALC-0315 en raison de son incompatibilit\u00e9 avec le foie et a d\u00e9velopp\u00e9 elle-m\u00eame la plate-forme SM (l'ALC-0315 s'\u00e9tait r\u00e9v\u00e9l\u00e9e trop toxique pour la th\u00e9rapie g\u00e9nique du syndrome de Crigler-Najjar, une maladie du foie, si bien que le partenaire de recherche de l'\u00e9poque <em>Alexion<\/em> a stopp\u00e9 l'\u00e9tude pour des raisons de s\u00e9curit\u00e9), BioNTech \/ Pfizer continue \u00e0 les utiliser contre toute \u00e9vidence.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_Weg_in_die_Leber_und_die_Lange_der_Kette\"><\/span>Le chemin vers le foie et la longueur de la cha\u00eene<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><\/p>\n\n\n\n<p>... se poursuit ...<\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Temps de lecture<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">minutes<\/span><\/span>Plus la cha\u00eene PEG (poly\u00e9thyl\u00e8ne glycol) est courte, plus la toxicit\u00e9 du LNP est \u00e9lev\u00e9e. C'est ce qu'explique BioNTech dans sa publication \"Non-Immunotherapy Application of LNP-mRNA : Maximizing Efficacy and Safety\" du 10.05.2021, m\u00eame si la formulation est - un peu - diff\u00e9rente : \"Maximizing Efficacy\".La toxicit\u00e9 est due au fait que les trois des lipides cationiques ionisables ne sont pas biod\u00e9gradables et que leur,...&nbsp;<a href=\"https:\/\/csiag.de\/fr\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/\" rel=\"bookmark\">Lire la suite \"<span class=\"screen-reader-text\">Toxicit\u00e9 des LNP en fonction de la longueur de la cha\u00eene PEG<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[628,316,1078],"tags":[5067,5066,5074,22,36,5080,5079,5069,5075,5071,4812,105,5073,5077,5070,5072,23,5076,5078,44],"class_list":["post-10036","post","type-post","status-publish","format-standard","hentry","category-corona","category-corona-blog","category-medizin","tag-alc-159","tag-alc-315","tag-alnylam","tag-biontech","tag-bnt162b2","tag-cholesterol","tag-dlin-mc3-dma","tag-dmg-peg2000","tag-elasomeran","tag-ionisierbar","tag-lnp","tag-moderna","tag-patisiran","tag-peg-lipid","tag-peg2000-dmg","tag-pegyliert","tag-pfizer","tag-phosholipid","tag-sterol","tag-tozinameran"],"acf":[],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.de\/fr\/wp-json\/wp\/v2\/posts\/10036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.de\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.de\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.de\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.de\/fr\/wp-json\/wp\/v2\/comments?post=10036"}],"version-history":[{"count":0,"href":"https:\/\/csiag.de\/fr\/wp-json\/wp\/v2\/posts\/10036\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.de\/fr\/wp-json\/wp\/v2\/media?parent=10036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.de\/fr\/wp-json\/wp\/v2\/categories?post=10036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.de\/fr\/wp-json\/wp\/v2\/tags?post=10036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}