{"id":7488,"date":"2024-06-15T11:35:25","date_gmt":"2024-06-15T11:35:25","guid":{"rendered":"https:\/\/csiag.de\/?p=7488"},"modified":"2026-01-19T11:57:51","modified_gmt":"2026-01-19T11:57:51","slug":"proteomics-and-essential-oils","status":"publish","type":"post","link":"https:\/\/csiag.de\/en\/blog\/2024\/06\/15\/proteomik-und-aetherische-oele\/","title":{"rendered":"Proteomics and Essential Oils"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of contents<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.de\/en\/blog\/2024\/06\/15\/proteomik-und-aetherische-oele\/#Wahrheitsfindung\" >Finding the truth<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.de\/en\/blog\/2024\/06\/15\/proteomik-und-aetherische-oele\/#Die_Nase_als_Schiedsrichter\" >The nose as referee<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.de\/en\/blog\/2024\/06\/15\/proteomik-und-aetherische-oele\/#Herstelleranfrage\" >Manufacturer inquiry<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.de\/en\/blog\/2024\/06\/15\/proteomik-und-aetherische-oele\/#Der_feine_Unterschied\" >The subtle difference<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.de\/en\/blog\/2024\/06\/15\/proteomik-und-aetherische-oele\/#Analytik\" >Analytics<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.de\/en\/blog\/2024\/06\/15\/proteomik-und-aetherische-oele\/#Studie_der_Roseman-University\" >Study by Roseman University<\/a><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Reading time<\/span> <span class=\"rt-time\"> 4<\/span> <span class=\"rt-label rt-postfix\">minutes<\/span><\/span>\n<p>Essential oils are offered by many manufacturers, for fragrance lamps, as flavorings for drinks and therapeutic applications.<\/p>\n\n\n\n<p>Proteomics is concerned with the identification of protein biomarkers using a combination of liquid chromatography and mass spectrography. Proteome research thus provides a complete overview of cellular processes at protein level.<br>One such device is, for example, the <a href=\"https:\/\/www.thermofisher.com\/order\/catalog\/product\/IQLAAEGAAPFADBMBHQ?SID=srch-srp-IQLAAEGAAPFADBMBHQ\" target=\"_blank\" rel=\"noreferrer noopener\">Fischer Thermo Scientific - Orbitrap Fusion Lumos Tribrid<\/a>.<\/p>\n\n\n\n<p>Why is an essential oil not the same as an essential oil, or is the effect more or less given?<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wahrheitsfindung\"><\/span>Finding the truth<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Establishing the truth is quite complex, as it is not clearly(!) regulated. Manufacturers can declare a product as a consumer product, for example, but also as a foodstuff. However, a product labeled as a consumer product cannot necessarily be used as a foodstuff.<\/p>\n\n\n\n<p>If you want to know exactly what your purchased product contains, you cannot avoid requesting a gas chromatographic and mass spectrographic analysis (GC-MS) from the manufacturer. This provides precise information on all ingredients and their concentration.<\/p>\n\n\n\n<p>The <strong>declaration<\/strong> of essential oils provides initial information on the authorized use:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Industrial quality - e.g. fragrance additives in cleaning agents<\/li>\n\n\n\n<li>On-demand products - e.g. room fragrancing<\/li>\n\n\n\n<li>Cosmetics - e.g. bath additives, skin care<\/li>\n\n\n\n<li>Food - e.g. flavoring, seasoning of foodstuffs<\/li>\n\n\n\n<li>Medicinal products - e.g. internal, external use<\/li>\n<\/ul>\n\n\n\n<p><strong>Mandatory information<\/strong> on the product packaging:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Company \/ name of responsible person, address<\/li>\n\n\n\n<li>Country of origin (for imports)<\/li>\n\n\n\n<li>Nominal content at the time of filling (weight \/ volume)<\/li>\n\n\n\n<li>Best before date<\/li>\n\n\n\n<li>Precautions for use<\/li>\n\n\n\n<li>Batch number, symbol for identification<\/li>\n\n\n\n<li>Intended use<\/li>\n\n\n\n<li>Ingredients (with INCI name in decreasing order)<\/li>\n<\/ul>\n\n\n\n<p><strong>Optional information<\/strong> are<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>German, botanical plant name<\/li>\n\n\n\n<li>Designation of the oil<br>- <em>natural, untreated<\/em><br>  unmodified oil<br>- <em>natural<\/em><br>  Oils with, from physical, enzymatic or microbiological processes <br>  ingredients<br>- <em>nature-identical<\/em><br>  in artificial processes are modeled on natural fragrance molecules, <br>  Molecular constructs derived from crude oil, <br>  usually very intense smelling<br>- <em>synthetic<\/em><br>  Fragrance oils that originate from fruits or animals that are neither distilled, <br>  nor, due to species protection, can be obtained from animal materials.<br>  They are produced purely synthetically. The designation then consists of the <br>  chemical name (e.g. benzylidene heptanal)<\/li>\n\n\n\n<li>Country of origin, cultivation<\/li>\n\n\n\n<li>Cultivation method<\/li>\n\n\n\n<li>Part of the plant used<\/li>\n\n\n\n<li>Extraction process<\/li>\n\n\n\n<li>Solvent, type of diluting oil, mixing ratio<\/li>\n\n\n\n<li>Certification, inspection body<\/li>\n\n\n\n<li>Safety instructions<\/li>\n\n\n\n<li>Dosage recommendation<\/li>\n\n\n\n<li>Hazard pictograms (for as <em>Consumables<\/em> oils placed on the market)<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Die_Nase_als_Schiedsrichter\"><\/span>The nose as referee<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Now, not everyone has the laboratory equipment for their own analysis, nor sufficient motivation to ask manufacturers for the relevant documentation (which, however, is highly advisable as it is a matter of personal health).<\/p>\n\n\n\n<p>Fortunately, our sense of smell is designed in such a way that it is able to distinguish between good and bad very precisely and extremely quickly, within only about 8 seconds (this is when the scent molecules reach the limbic system). An unusually intense odor or e.g. headache, nausea indicate synthetic components in the oil. The same goes for our skin, which reacts to allergens with redness, even if it takes several minutes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Herstelleranfrage\"><\/span>Manufacturer inquiry<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>If you take the trouble to search for the relevant information directly on the manufacturer's website, you will very rarely find it. I am currently only aware of two manufacturers who offer the option of viewing the GC-MS data for a specific batch on their website.<\/p>\n\n\n\n<p>Other competitors only disclose this information on explicit request or not at all, citing \u201etrade secrets\u201c. Experiences in the search for laboratory analyses of essential oil suppliers were <a href=\"https:\/\/csiag.de\/en\/essential-oils-odyssey-of-a-quest\/\" data-type=\"post\" data-id=\"8372\">here<\/a> described in detail.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_feine_Unterschied\"><\/span>The subtle difference<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The subtle difference can therefore only be discovered with a certain amount of self-initiative.<\/p>\n\n\n\n<p>Another quality feature may initially be the price. An oil with therapeutic purity, i.e. natural purity and officially declared as a medicinal product, will be significantly more expensive than an oil approved as a consumer product.<\/p>\n\n\n\n<p>Similarly, an oil with a high concentration of active ingredients will definitely be more expensive than one with a lower intensity.<\/p>\n\n\n\n<p>Why, for example, is one lavender oil more effective than another, even though they are all naturally pure?<\/p>\n\n\n\n<p>The first difference lies in the botanical name of the plant. There are around 37 different species. The soil conditions are also decisive for the active ingredient content, as are the intensity of the sun during the growth phase, soil moisture, the time of harvest, distillation and bottling.<br>All factors determine the possible therapeutic purpose.<\/p>\n\n\n\n<p>There are very few essential oil manufacturers on the world market who bottle their oils themselves. Cheaper suppliers often purchase their oils on oil exchanges. Oils from different suppliers are mixed and bottled there. This means that it is no longer possible to trace the cultivation, harvesting and distillation conditions.<\/p>\n\n\n\n<p>Comparing apples with apples should actually be possible, but comparing a specific apple variety with the same variety is more problematic. So gas and mass spectrography after all ...<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Analytik\"><\/span>Analytics<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>With the help of the above-mentioned analysis technique, the following aspects are the subject of a differentiated investigation:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Protein identification<br>Which proteins are formed under normal conditions in a defined cell type, tissue or body fluid?<\/li>\n\n\n\n<li>Protein quantification<br>How is the <em>Protein abundance<\/em>* in a specific cell type, tissue or body fluid? Which proteins are differentially expressed?<br>* Under <em>Protein abundance<\/em> is the protein abundance calculated from the sum of all unique, normalized peptide ion abundances for the respective protein in each measurement run.<\/li>\n\n\n\n<li>Post-translational modifications<br>If the protein shows disease-relevant, <em>posttranslational<\/em>* changes?<br>* <em>Post-translational<\/em> Modifications refer to changes in the properties of proteins through the addition of charged groups or hydrophobic molecules (lipids), e.g. the binding properties of a protein to other proteins or cell membranes.<\/li>\n\n\n\n<li>Protein localization<br>Where is the protein formed, where does it accumulate? Localization of the protein in the cell, the tissue.<\/li>\n\n\n\n<li>Functional proteomics<br>Which protein function change results depending on the concentration, modification, localization or surrounding network? Identification of the biological function of individual proteins.<\/li>\n\n\n\n<li>Protein-protein interactions<br>How does a protein network change depending on a disease, which proteins interact?<\/li>\n<\/ul>\n\n\n\n<p>In addition to the above analyses relating to proteomics, other test methods are essential to ensure the therapeutic quality of essential oils, such as Fourier transform infrared spectroscopy (FTIR), gas chromatography, isotope analysis, mass spectroscopy, microbial, organoleptic and heavy metal testing.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Studie_der_Roseman-University\"><\/span>Study by Roseman University<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>In one <a href=\"https:\/\/www.roseman.edu\/student-experience\/news\/roseman-university-researchers-study-doterra-essential-oils\/\" target=\"_blank\" rel=\"noreferrer noopener\">Contribution<\/a> from October 3, 2018, scientists Drs. Tim Le and Jeffrey Talbot from the College of Pharmacy at Roseman University of Health Sciences, Nevada, describe their proteomic analysis of essential oils from various manufacturers, including d\u014dTERRA.<\/p>\n\n\n\n<p>It could be proven that (quote): <em>Dr. Talbot adds that the therapeutic potential of essential oils is highly dependent on the complete composition of the oil. Sourcing, processing and characterization are critical.<\/em><br>(Translation: <em>Dr. Talbot adds that the therapeutic potential of essential oils is highly dependent on the overall composition of the oil. Sourcing, processing and characterization are crucial.<\/em>)<\/p>\n\n\n\n<p>The attempt to reproduce the effect profile and mechanism of action by isolating the individual active ingredients and \"artificially\" combining them failed. The human organism obviously recognizes the existence of a symbiosis of all the effective components of an essential oil and only reacts to these in the intended way.<\/p>\n\n\n\n<p>The studies will continue as part of research into the therapeutic potential of nutraceuticals by Roseman University's School of Pharmacy.<\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Reading time<\/span> <span class=\"rt-time\"> 4<\/span> <span class=\"rt-label rt-postfix\">minutes<\/span><\/span>Essential oils are offered by many manufacturers, for fragrance lamps, as flavorings for beverages and therapeutic applications. Proteomics is concerned with the identification of protein biomarkers using a combination of liquid chromatography and mass spectrography. Proteomics research thus provides a complete overview of cellular processes at protein level, for example the Fischer Thermo Scientific - Orbitrap Fusion Lumos...&nbsp;<a href=\"https:\/\/csiag.de\/en\/blog\/2024\/06\/15\/proteomik-und-aetherische-oele\/\" rel=\"bookmark\">Read More \"<span class=\"screen-reader-text\">Proteomics and Essential Oils<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[3401,3402],"tags":[3449,3464,3425,3439,3422,3094,3418,3432,3434,3453,3455,3454,3463,3417,3442,3445,3451,3405,3415,3430,3441,1446,3452,3433,3420,3462,3457,3419,3458,3421,3448,3443,3406,3427,3446,3437,3436,3435,3426,3466,3465,3459,3409,3440,3423,3413,2104,3407,3411,3414,3416,3412,3404,3408,3403,3456,3447,3460,3450,3428,3438,3410,3461,1101,3424,3431,3429,3444],"class_list":["post-7488","post","type-post","status-publish","format-standard","hentry","category-aetherische-oele","category-proteomik","tag-allergene","tag-analytik","tag-anbauland","tag-anbauweise","tag-arzneimittel","tag-aetherische-oele","tag-bedarfsmittel","tag-bestandteile","tag-botanischer-name","tag-charge","tag-chargen-nummer","tag-chargennummer","tag-college-of-pharmacy","tag-deklaration","tag-destillation","tag-dosierempfehlung","tag-duftmolekuele","tag-fluessigkeitschromatografie","tag-funktionelle-proteomik","tag-gebrauch","tag-gewinnungsverfahren","tag-haut","tag-hersteller","tag-inci","tag-industrielle-qualitaet","tag-jeffrey-talbot","tag-kopfschmerz","tag-kosmetik","tag-lavendeloel","tag-lebensmittel","tag-limbisches-system","tag-loesungsmittel","tag-massenspektrografie","tag-mindesthaltbarkeitsdatum","tag-nase","tag-naturidentisch","tag-natuerlich","tag-naturrein","tag-nenninhalt","tag-nutrazeutika","tag-nutrazeutikum","tag-oelboerse","tag-orbitrap-fusion-lumos-tribrid","tag-pflanzenteil","tag-pflichtangaben","tag-posttranslationale-modifikationen","tag-protein","tag-protein-biomarker","tag-protein-identifizierung","tag-protein-lokalisierung","tag-protein-protein-wechselwirkungen","tag-protein-quantifizierung","tag-proteine","tag-proteomforschung","tag-proteomik","tag-qualitaetsmerkmal","tag-riechsinn","tag-roseman-university","tag-roetung","tag-sicherheitshinweise","tag-synthetisch","tag-thermo-fischer-scientific","tag-tim-le","tag-uebelkeit","tag-ursprungsland","tag-verwendungszweck","tag-vorsichtsmassnahmen","tag-zertifizierung"],"acf":[],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/posts\/7488","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/comments?post=7488"}],"version-history":[{"count":0,"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/posts\/7488\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/media?parent=7488"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/categories?post=7488"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/tags?post=7488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}