{"id":11899,"date":"2025-12-23T12:28:25","date_gmt":"2025-12-23T12:28:25","guid":{"rendered":"https:\/\/csiag.de\/?p=11899"},"modified":"2026-01-03T17:24:37","modified_gmt":"2026-01-03T17:24:37","slug":"autoimmune-disease-and-immunomodulation-of-essential-oils","status":"publish","type":"post","link":"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/","title":{"rendered":"Autoimmune disease and immunomodulation of essential oils"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of contents<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Autoimmunitat\" >Autoimmunity<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Immunsuppression\" >Immunosuppression<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Immunmodulation\" >Immunomodulation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Studien\" >Studies<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Atherische_Ole\" >Essential oils<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Chemotypen_Ct\" >Chemotypes (Ct.)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Tragerol\" >Carrier oil<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Wirkmechanismen\" >Mechanisms of action<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#1_Von_der_Nase_ins_Gehirn\" >1. from the nose to the brain<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#2_Durch_die_Haut_ins_Blut\" >2. through the skin into the blood<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#3_Auf_zellularer_Ebene\" >3. at the cellular level<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Atherische_Ole_%E2%80%93_schalten_Entzundungs-Schalter_aus\" >Essential oils - turn off the inflammation switch<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#%E2%80%A6_beruhigen_ubereifrige_Immunzellen\" >... calm overzealous immune cells<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#%E2%80%A6_verandern_die_Balance\" >... change the balance<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#%E2%80%A6_blockieren_Entzundungsstoffe\" >... block inflammatory substances<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#%E2%80%A6_schutzen_vor_oxidativem_Stress\" >... protect against oxidative stress<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Atherische_Ole_%E2%80%93_im_Einzelnen\" >Essential oils - in detail<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Frankincense_Weihrauch\" >Frankincense (Frankincense)<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Frankincense_Weihrauch-Ol\" >Frankincense (frankincense oil)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Frankincense_Boswellia-Saure\" >Frankincense (boswellic acid)<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Copaiba\" >Copaiba<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Oregano\" >Oregano<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Lavendel\" >Lavender<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Eukalyptus\" >Eucalyptus<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Nelke\" >Carnation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Teebaum\" >Tea tree<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Thymian\" >Thyme<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Rosmarin\" >Rosemary<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Zitrusole_Orange_Zitrone_Bergamotte\" >Citrus oils (orange, lemon, bergamot)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Ol-Kombinationen_fur_verschiedene_Autoimmunerkrankungen\" >Oil combinations for various autoimmune diseases<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Multiple_Sklerose_MS\" >Multiple sclerosis (MS)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Rheumatoide_Arthritis\" >Rheumatoid arthritis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Morbus_Crohn_Colitis\" >Crohn's disease \/ colitis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Lupus_Systemischer_Lupus_Erythematodes\" >Lupus (Systemic Lupus Erythematosus)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Wechselwirkungen_mit_Biologika\" >Interactions with biologics<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Was_sind_Biologika\" >What are biologics?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-37\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Hauptklassen_der_Biologika\" >Main classes of biologics<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-38\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#TNF-%CE%B1-Inhibitoren\" >TNF-\u03b1 inhibitors<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-39\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Interleukin-Inhibitoren\" >Interleukin inhibitors<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-40\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#B-Zell-Depletoren\" >B-cell depletors<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-41\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#T-Zell-Kostimulationshemmer\" >T-cell costimulation inhibitors<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-42\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Integrin-Antagonisten\" >Integrin antagonists<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-43\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Potenzielle_additive_entzundungshemmende_Effekte\" >Potential additive anti-inflammatory effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-44\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Immunmodulatorische_Effekte\" >Immunomodulatory effects<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-45\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Theoretische_Risiken\" >Theoretical risks<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-46\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Verstarkte_Immunsuppression\" >Increased immunosuppression<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-47\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Erhohtes_Infektionsrisiko\" >Increased risk of infection<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-48\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Allergische_Reaktionen_und_Hautreaktionen\" >Allergic reactions and skin reactions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-49\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Leberstoffwechsel_und_Arzneimittelinteraktionen\" >Liver metabolism and drug interactions<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-50\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Spezifische_Uberlegungen_zu_Immunsuppressiva\" >Specific considerations for immunosuppressants<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-51\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#TNF-%CE%B1-Inhibitoren_Atherische_Ole\" >TNF-\u03b1 inhibitors + essential oils<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-52\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Interleukin-Inhibitoren_Atherische_Ole\" >Interleukin inhibitors + essential oils<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-53\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#B-Zell-Depletoren_Rituximab\" >B-cell depletors (rituximab)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-54\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Praktische_Empfehlungen\" >Practical recommendations<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-55\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Sichere_Anwendung_bei_Biologika-Therapie\" >Safe use with biologics therapy:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-56\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Relative_Sicherheit_%E2%80%93_Empfohlene_Ole\" >Relative safety - Recommended oils:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-57\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#%E2%80%A6_zu_vermeidende_oder_nur_nach_arztlicher_Rucksprache\" >... to be avoided or only after consultation with a doctor:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-58\" href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Fazit\" >Conclusion<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n\n<p class=\"wp-block-paragraph\">Autoimmune diseases and immunomodulation are directly related. How essential oils have an immunomodulatory effect will be explained below in a way that is understandable for both medical laypersons and medical professionals (by means of studies).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">First of all, three terms whose meaning should be clarified in order to avoid possible ambiguities:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Autoimmunity<\/li>\n\n\n\n<li>Immunosuppression<\/li>\n\n\n\n<li>Immunomodulation<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Autoimmunitat\"><\/span>Autoimmunity<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Autoimmunity is the term used to describe a pathological (<em>pathological<\/em>) Immune response of the human organism against the body's own antigens (e.g. bacteria, viruses) as a result of which healthy structures (e.g. cells, tissue) are attacked, which in turn lead to the formation of autoantibodies against the body's own proteins and inflammation, destruction of cells or tissue, as well as organ dysfunction (<em>Dysfunction<\/em>).<br>Autoimmunity is synonymous with autoimmune disease.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Immunsuppression\"><\/span>Immunosuppression<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Immunosuppression is the suppression of one or both of the body's immune systems, the <em>humoral<\/em> (non-cellular components of body fluids (e.g. blood, lymph) and the acquired body fluid), <em>cellular<\/em> (represented by the \u201ekiller cells\u201c, or. <em>T-cells<\/em> \/ -<em>Lymphocytes<\/em>) immune system.<br>It can be triggered by illness, stress, exposure to radiation or medical treatment.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Immunmodulation\"><\/span>Immunomodulation<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Immunomodulation is the regulatory intervention in the immune system, both dampening and stimulating. The aim is to restore normal regulatory behavior (e.g. dampening (<em>suppressive<\/em>) in the presence of autoimmunity or promoting (<em>stimulative<\/em>) for immunodeficiency.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Normally, our immune system protects us from pathogens such as viruses and bacteria. In the case of autoimmune diseases, however, the immune system makes a mistake: it suddenly attacks the body's own healthy cells as if they were enemies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The immune system produces too many \u201eattack signals\u201c (inflammatory messengers such as <em>TNF-\u03b1, IL-6, IL-1\u03b2<\/em>). These keep the inflammation going, even if there is no real enemy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Examples of autoimmune diseases:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Multiple sclerosis (MS) - attack on <strong>Nerve sheaths<\/strong><\/li>\n\n\n\n<li>Rheumatoid arthritis - attack on <strong>Joints<\/strong><\/li>\n\n\n\n<li>Crohn's Disease &amp; Ulcerative Colitis - Attack on the <strong>Colon<\/strong><\/li>\n\n\n\n<li>Hashimoto's - attack on the <strong>Thyroid gland<\/strong><\/li>\n\n\n\n<li>Lupus ... - Attack on various <strong>Organs<\/strong> (...)<\/li>\n\n\n\n<li>Type 1 diabetes - attack on <strong>Pancreas<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Studien\"><\/span>Studies<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">All the studies listed are written in English. A summary in German follows each study link and thus provides a rough overview of the key findings of the respective study.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If the study is available in full text, this link was given preference. Studies that are not available in full text can usually be viewed in the respective publication for a fee, more rarely only with registration via an institution.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Notice<\/strong>Some links require multiple \u201eI am human\u201c verifications.<\/p>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Atherische_Ole\"><\/span>Essential oils<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Chemotypen_Ct\"><\/span>Chemotypes (Ct.)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Chemotypes are used to differentiate essential oils of a plant species whose main active ingredient content varies due to different growing conditions (e.g. soil conditions, altitude, climate, UV radiation, time of harvest) and thus also the effect of the resulting oil.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">One example is thyme: Thyme (<em>Ct. thymol)<\/em> has a stronger stimulating, antiseptic, expectorant effect, while thyme (<em>Ct. linalool<\/em>) has a softer, calming and relaxing effect.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Depending on the intended effect, the knowledge and choice of chemotype is of fundamental importance.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tragerol\"><\/span>Carrier oil<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Essential oils (EO) are highly volatile substances. Some essential oils have an irritating effect on the skin when undiluted. Carrier oils are ideal for effectively counteracting both properties, minimizing volatility, diluting the oils and increasing bioavailability when used topically (on the skin) or internally.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">All oils with skin-caring properties are suitable as carrier oils for topical application, e.g. <em>Argan, jojoba, almond, coconut oil<\/em>, for internal use all cold-pressed (native) edible oils.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wirkmechanismen\"><\/span>Mechanisms of action<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">For a more detailed description, please refer to the article \u201e<a href=\"https:\/\/csiag.de\/en\/essential-oils-why-do-they-work\/?hilite=hatt\" target=\"_blank\" rel=\"noreferrer noopener\">Essential oils - why they work<\/a>?\u201c referred to.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_Von_der_Nase_ins_Gehirn\"><\/span>1. <strong>From the nose to the brain<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">When smelling (<em>olfactory<\/em> \/ aromatic) of an essential oil, its fragrance molecules reach the brain directly. There (in the limbic system) they can:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Reduce stress (less cortisol)<\/li>\n\n\n\n<li>Improve the mood<\/li>\n\n\n\n<li>Calm the nervous system<\/li>\n\n\n\n<li>Indirectly influence the immune system positively<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_Durch_die_Haut_ins_Blut\"><\/span>2. <strong>Through the skin into the blood<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">On the skin (<em>topical<\/em>) can be applied to the tiny molecules:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>get into the blood<\/li>\n\n\n\n<li>migrate to inflamed areas<\/li>\n\n\n\n<li>have a direct anti-inflammatory effect there<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_Auf_zellularer_Ebene\"><\/span>3. <strong>At the cellular level<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">As soon as the active ingredients enter the body's cells, they develop their systemic effect:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Block inflammatory messengers<\/li>\n\n\n\n<li>calm misdirected immune cells<\/li>\n\n\n\n<li>Activate protective mechanisms<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Atherische_Ole_%E2%80%93_schalten_Entzundungs-Schalter_aus\"><\/span>Essential oils - turn off the inflammation switch<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Let's imagine that there is an \u201einflammation master switch\u201c (called NF-\u03baB) in our cells. Many essential oils can turn this switch \u201eOFF\u201c.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%80%A6_beruhigen_ubereifrige_Immunzellen\"><\/span><strong>... calm overzealous immune cells<\/strong> <span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Certain immune cells (<em>T cells, macrophages<\/em>) are overactive in autoimmune diseases. In concrete terms, this means that they constantly send out alarm signals, produce too many inflammatory messengers and attack healthy tissue like overzealous guard dogs that also bark at family members. <br>The consequences are, for example, permanent inflammation, swelling, pain and tissue damage.<br>Essential oils can \u201eshut down\u201c these cells in the same way that you slow down an engine that is too loud. This makes the cells react less aggressively.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%80%A6_verandern_die_Balance\"><\/span><strong>... change the balance<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">The immune system has \u201eaggressive\u201c and \u201epeaceful\u201c cells. The aggressive (<em>Th1, Th17<\/em>) are like attack troops fighting off intruders, but can also react far too aggressively.<br>The peaceful (<em>Th2, Treg<\/em>) are like diplomats, they appease and regulate.<br>In autoimmune diseases, there are too many aggressive cells. This leads to excessive immune reactions, chronic inflammation and tissue damage.<br>Some oils help to create more peaceful cells, which then keep the aggressive ones in check and reduce inflammation.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%80%A6_blockieren_Entzundungsstoffe\"><\/span><strong>... block inflammatory substances<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">During inflammation, the body produces substances such as <em>Leukotrienes<\/em> and <em>Prostaglandins<\/em>, chemical messengers that trigger pain, swelling, redness and fever.<br>In autoimmune diseases, these substances are permanently produced in large quantities, which leads to chronic symptoms such as swollen, aching joints, persistent fatigue, tissue that feels warm and reddened.<br>Certain oils block the enzymes that produce these inflammatory substances, similar to pharmaceuticals such as. <em>Aspirin<\/em> or <em>Ibuprofen<\/em>, only in a natural way and without undesirable side effects.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%80%A6_schutzen_vor_oxidativem_Stress\"><\/span><strong>... protect against oxidative stress<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Inflammation produces aggressive molecules (<em>free radicals<\/em>), unstable particles that attack and damage healthy cells like small \u201eprojectiles\u201c. This damage accumulates, causing cell membranes to become porous and DNA to be damaged, and tissue ages more quickly.<br>The result is even more inflammation, exhaustion and accelerated tissue breakdown.<br>Many essential oils contain antioxidants that neutralize these free radicals, like a protective shield that intercepts the \u201eprojectiles\u201c before they can do any damage.<\/p>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Atherische_Ole_%E2%80%93_im_Einzelnen\"><\/span>Essential oils - in detail<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The following applies to all essential oils: they must be pure and natural WITHOUT any additives, ideally proven by a gas chromatographic analysis by a laboratory independent of the manufacturer. NO use of fragrance oils, synthetically produced, modified or mixed oils.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A <strong>analysis<\/strong> (using frankincense oil as an example) contain data (values in %) as follows:<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"wp-block-paragraph\">alpha-Pinene<br>alpha-Thujene<br>Limonene<br>para-Cymene<br>Sabinene<br>Myrcenae<br>Octyl acetate<br>beta-Pinene<br>beta-Caryophyllene<br>Terpinen-4-ol<br>alpha-Phellandrene<br>delta-3-Carene<br>Camphene<br>...<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<p class=\"wp-block-paragraph\">37.44<br>10.80<br>  9.46<br>  5.75<br>  4.09<br>  3.53<br>  3.22<br>  1.83<br>  1.81<br>  1.47<br>  1.24<br>  1.24<br>  1.20<br>...<\/p>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">The <strong>Effect<\/strong> of the individual main components:<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">alpha-Pinene<br>alpha-Thujene<br>Limonene<br>para-Cymene<br>Sabinene<br>Octyl acetate<br>beta-Caryophyllene<br>Terpinen-4-ol<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Strongly anti-inflammatory<br>antimicrobial, immunomodulating<br>antioxidant, anti-inflammatory<br>analgesic, anti-inflammatory<br>antioxidant<br>soothing<br><em>CB2 receptor agonist<\/em> (like Copaiba)<br>immunomodulating (as in tea tree oil)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Frankincense_Weihrauch\"><\/span>Frankincense (Frankincense)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Two different products are obtained from the resin of the frankincense tree: the essential oil (contains <em>Monoterpenes<\/em>) and the boswellia resin (contains <em>Boswellic acids<\/em>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Both substances have different effects, but complement each other perfectly (see below).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Frankincense_Weihrauch-Ol\"><\/span>Frankincense (frankincense oil)<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Frankincense oil has a dose-dependent effect on autoimmunity: while a <strong>low<\/strong> Dosage for <strong>normalization<\/strong> contributes to the activity of the immune system <strong>high<\/strong> Tins <strong>stimulating<\/strong>, which must be avoided in the case of autoimmunity! It is therefore essential to know the exact ingredients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Based on the above analysis data, frankincense oil can be used in adults and children.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Rheumatoid arthritis<\/strong> - Application to the affected joints<\/li>\n\n\n\n<li><strong>Multiple sclerosis (MS)<\/strong> - Apply to the neck, spine and soles of the feet<\/li>\n\n\n\n<li><strong>Crohn's disease \/ colitis<\/strong> - Massage the abdominal area in a clockwise direction<\/li>\n\n\n\n<li><strong>Lupus<\/strong> ... - On joints and painful areas (avoid sun exposure)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>topical<\/strong> in<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>low dosage (for testing) - at 0.5 - 1 percent dilution (3 - 6 drops to 30 ml carrier oil),<br>for application, even over large areas<\/li>\n\n\n\n<li>medium dosage (chron.) - at 1 - 2 percent dilution (6 - 12 drops to 30 ml carrier oil),<br>Apply 2-3 times a day to the affected areas<\/li>\n\n\n\n<li>higher dosage (acute) - at 2-3% dilution (12 - 18 drops per 30 ml carrier oil),<br>max for 1-2 weeks (then back to medium dosage) applied 3-4 times daily<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">be applied.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Inhalative<\/strong> for systemic effects and stress reduction via ultrasonic nebulizer \/ diffuser 3 ... 5 trp. in water for 30 ... 60 min. 2 ... 3 times a day.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For products that <em>Boswellic acid<\/em> the content of <strong>AKBA<\/strong> (<em>Acetyl-11-keto-\u03b2-boswellic acid<\/em>) is decisive for quality and efficacy, which underlines the importance of independent batch analysis of such products (see also the <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6836131\/\" target=\"_blank\" rel=\"noreferrer noopener\">study<\/a> of the University of Ulm from 10.2019 \u201e<em>Comparative Investigation of Frankincense Nutraceuticals ...<\/em>\u201e).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Boswellic acids act through<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Blocking the <em>Leukotriene production<\/em><\/strong> by inhibiting the enzyme <em>5-Lipoxygenase (5-LOX)<\/em><br>Leukotrienes are aggressive messenger substances that are released during inflammation.<br>They cause:<br>- Severe swelling (joints)<br>- Constriction of the bronchial tubes (shortness of breath with asthma)<br>- Increase in mucus production<br>- Accumulation of further inflammatory cells<br>- Chronic tissue damage<\/li>\n\n\n\n<li><strong>Inhibition of the <em>Prostaglandin synthesis<\/em><\/strong><br>Prostaglandins are inflammatory messengers that increase pain.<\/li>\n\n\n\n<li><strong>Suppression of the <em>NF-\u03baB signaling pathway<\/em><\/strong><br><em>NF-\u03baB <\/em>is the \u201einflammation master switch\u201c in cells. When it is active, hundreds of pro-inflammatory genes are switched on. Boswellic acids turn off this master switch, stopping the entire inflammatory cascade.<\/li>\n\n\n\n<li><strong>Inhibition of the <em>Complement system<\/em><\/strong> as part of the immune defense<br>In autoimmune diseases, it mistakenly attacks the body's own cells. Boswellic acids inhibit the key enzyme <em>C3 convertase<\/em>, which curbs autoimmune attacks.<\/li>\n\n\n\n<li><strong>Passage of the <em>Blood-brain barrier<\/em><\/strong><br>A particularly important property of boswellic acids in<br>- Multiple sclerosis (inflammation in the CNS)<br>- Brain tumors with swellings<br>- Cerebral edema after a stroke<br>because they work against<br>- Gehrin inflammation (neuroinflammation)<br>- Nerve cell damage (oxidative stress)<br>- Nerve degeneration (neurodegeneration)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">These effects have been proven by studies:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Multiple sclerosis (MS)<\/strong> - 800 .. 1,200 mg\/d<br><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.894880\/full\" target=\"_blank\" rel=\"noreferrer noopener\">Frontiers in Neurology (2022)<\/a><\/li>\n\n\n\n<li><strong>Crohn&#039;s disease<\/strong> - 900 .. 1,200 mg\/d<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11215357\/\" target=\"_blank\" rel=\"noreferrer noopener\">Journal of Gastroenterology (2001)<\/a><\/li>\n\n\n\n<li><strong>Ulcerative colitis<\/strong> - 1.000 .. 3,600 mg\/d<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11488449\/\" target=\"_blank\" rel=\"noreferrer noopener\">Planta Medica (2001)<\/a><\/li>\n\n\n\n<li><strong>Psoriasis<\/strong> - 1.000 .. 2,400 mg\/d<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25395868\/\" target=\"_blank\" rel=\"noreferrer noopener\">Clinical, Cosmetic and Investigational Dermatology (2010)<\/a><\/li>\n\n\n\n<li><strong>Type 1 diabetes<\/strong><br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21596544\/\" target=\"_blank\" rel=\"noreferrer noopener\">Phytomedicine (2011)<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">The effect of boswellic acids is doubled due to their fat solubility when taken together with high-fat food!<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Resulting dosage recommendation for an adult (70 kg) of AKBA in mg\/d:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Multiple sclerosis - 40 ... 60<\/li>\n\n\n\n<li>Crohn's disease - 40 ... 60<\/li>\n\n\n\n<li>Ulcerative colitis - 40 ... 60<\/li>\n\n\n\n<li>Rheumatoid arthritis - 50 ... 80<\/li>\n\n\n\n<li>Osteoarthritis, mild - 20 ... 30<\/li>\n\n\n\n<li>Osteoarthritis, severe - 50 ... 80<\/li>\n\n\n\n<li>Asthma - 30 ... 40<\/li>\n\n\n\n<li>Psoriasis - 40 ... 60<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Frankincense_Boswellia-Saure\"><\/span>Frankincense (boswellic acid)<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">The main internal (systemic) anti-inflammatory active ingredients of boswellic acid are<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AKBA<\/strong> (<em>3-O-acetyl-11-keto-\u03b2-boswellic acid<\/em> - 5-LOX inhibition)<\/li>\n\n\n\n<li><strong>KBA<\/strong> (<em>11-keto-\u03b2-boswellic acid<\/em>)<\/li>\n\n\n\n<li><strong>\u03b2-BA<\/strong> (<em>beta-Boswellic acid<\/em>)<br>- <strong>Binds to TLR4 receptors<\/strong> (Toll-like Receptor 4) and blocks this<br><em>TLR4<\/em> is an alarm receptor that recognizes damaged molecules and activates inflammatory genes, creating a vicious circle in autoimmunity<br>- <strong>Inhibits the TLR4\/IL-1R signaling pathway<\/strong> (anti-arthritic effect)<br>- <strong>Reduces MAPK p38\/NF-\u03baB activation<\/strong><br><em>MAPK p38<\/em> is a signaling chain that activates inflammatory genes and cartilage-destroying enzymes (MMPs), <em>COX-2<\/em>, <em>Cytokines<\/em> produced; <em>NF-\u03baB<\/em> activates 250 genes, some of which in turn <em>NF-\u03baB genes<\/em> activate. (chronic inflammation)<br>- <strong>Inhibits the NLRP3 inflammasome<\/strong> (chronic inflammation)<br>- <strong>Lowers IL-6, TNF-\u03b1, COX-2<\/strong> in joint chondrocytes<br>- Protects cartilage from degradation (osteoarthritis)<br>- <strong>Inhibits prostaglandin E synthase 1<\/strong> (<em>PGES-1<\/em>), while protective prostacyclin remains untouched<br>  <em>PGES-1<\/em> produces the main inflammatory messenger substance that causes pain, fever and swelling <em>PGE2<\/em><br>- <strong>Inhibits cathepsin G<\/strong> (<em>Serine protease<\/em>)<br>  Cathepsin G destroys cartilage and connective tissue (RA), blood vessel walls (vasculitis), intestinal mucosa (IBD) and forms NETs (harmful in autoimmunity)<br>- achieves a higher bioavailability when taken orally due to better <strong>100 times higher blood concentration<\/strong> as AKBA<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">AKBA and KBA can be a <strong>pro-inflammatory enzyme<\/strong> (<em>5-Lipoxygenase<\/em>) in the body so that it can <strong>has an anti-inflammatory effect<\/strong>. A unique property among natural substances!<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">AKBA does not directly block the active center by means of oxidation\/reduction, as is usually the case with other inhibitory substances, but binds 3 nm away from the center, exactly between the membrane-binding and catalysis parts, and restructures the enzyme form.<br>This will <em>LOX-5 <\/em>induces less inflammation-promoting <em>Leukotrienes<\/em> at position <em>5<\/em> the <em>Arachidonic acid<\/em> but - in position <em>12\/15<\/em> - less inflammation-promoting and also inflammation-dissolving <em>Lipoxins<\/em> and <em>Resolvine<\/em> to produce (1<em>5-LOX activation<\/em>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7747934\/\" target=\"_blank\" rel=\"noreferrer noopener\">study<\/a> describes the <em>Enzyme binding<\/em> from <em>AKBA<\/em>, these <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36567268\/\" target=\"_blank\" rel=\"noreferrer noopener\">study<\/a> the 1<em>5-LOX activation<\/em>.<\/p>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Copaiba\"><\/span>Copaiba<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\u03b2-Caryophyllene<\/em> binds to <em>CB2<\/em>-receptors of immune cells, similar to cannabis, but without the intoxicating component of cannabis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Copaiba calms aggressive immune cells, which leads to a reduction in the inflammatory reactions caused, both in affected tissues and in the brain and spinal cord, which in turn means a reduction in pressure due to reduced swelling and a functional improvement in nerve cells, such as a reduction in numbness and paralysis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In multiple sclerosis, the myelin layer that protects the nerve fibres, but which has become porous due to the immune reaction, is remyelized, which improves nerve conductivity.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the brain, the microglia immune cells are switched from \u201eattack\u201c to \u201eheal\u201c, allowing the removal of cell remnants and preventing further damage to the nerve cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This results in the scope of application<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Multiple sclerosis (MS)<\/li>\n\n\n\n<li>Neurological autoimmune diseases<\/li>\n\n\n\n<li>Neuropathic pain<\/li>\n\n\n\n<li>Inflammation of the central nervous system<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">which have been proven in the following studies:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Alberti TB et al.<\/strong> <strong>(2017)<\/strong> - \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28368293\/\" target=\"_blank\" rel=\"noreferrer noopener\">(-)-\u03b2-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis<\/a>\u201c <br>Basic MS study - BCP inhibited microglial cells, CD4+\/CD8+ T lymphocytes and proinflammatory cytokines - Reduced axonal demyelination - Modulated Th1\/Treg balance through CB2 activation<\/li>\n\n\n\n<li><strong>Askari VR et al. (2023)<\/strong> - \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37509022\/\" target=\"_blank\" rel=\"noreferrer noopener\">Low Doses of \u03b2-Caryophyllene Reduced Clinical and Paraclinical Parameters of an Autoimmune Animal Model of Multiple Sclerosis<\/a>\u201e<br>Low-dose study - Low doses (2.5-5 mg\/kg) were optimal - Shifted immune system from M1\/Th1\/Th17 (inflammatory) to M2\/Th2\/Treg (curative) - Increased IL-10 (anti-inflammatory), reduced TNF-\u03b1, IL-6, IL-17 - Acted more on systemic than CNS immune system<\/li>\n\n\n\n<li><strong>Askari VR &amp; Shafiee-Nick R (2017) <\/strong>- \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28463791\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u03b2-Caryophyllene ameliorates the development of experimental autoimmune encephalomyelitis in C57BL\/6 mice<\/a>\u201e<br>Mechanism study - Protected oligodendrocytes (myelin-producing cells) from LPS toxicity - Acted via CB2 \u2192 Nrf2\/HO-1 (low doses) and PPAR-\u03b3 (high doses) - Reduced ROS, NO, TNF-\u03b1 - Promoted M2 microglia phenotype (healing)<\/li>\n\n\n\n<li><strong>Vafa Baradaran Rahimi, Vahid Reza Askari (2022) <\/strong>- \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35648433\/\" target=\"_blank\" rel=\"noreferrer noopener\">A mechanistic review on immunomodulatory effects of selective type two cannabinoid receptor \u03b2-caryophyllene<\/a>\u201e<br>Comprehensive overview of all mechanisms - Antioxidant through Nrf2\/HO-1 axis - Immunomodulatory through CB2 activation - Inhibits MAPK p38 and NF-\u03baB<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Oregano\"><\/span>Oregano<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Oregano can be seen as a \u201ebrake\u201c on overactive T cells, the command center of the immune system, as it reduces the production of inflammatory messengers by up to 70%. This results in significantly fewer IL-2 and IFN-\u03b3 key messengers, which accelerate inflammation and damage tissue.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It also stops overzealous T cells that attack healthy tissue because they receive false information suggesting that the healthy cells in the tissue need to be fought.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In multiple sclerosis (MS), it activates the MBP and OLIG2 genes responsible for cell regeneration, which are specifically responsible for repairing the myelin layer that has become patchy as a result of the disease.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the brain, it prevents inflammatory cells from entering and spreading by breaking this inflammatory cascade and thereby reducing neurological symptoms.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This results in the following areas of application<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Multiple sclerosis (MS)<\/li>\n\n\n\n<li>Rheumatoid arthritis<\/li>\n\n\n\n<li>T-cell-induced autoimmune diseases<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">which are substantiated by these studies:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Khorsandi L et al. (2019)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0024320518307720?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">Carvacrol ameliorates experimental autoimmune encephalomyelitis through modulating pro- and anti-inflammatory cytokines<\/a>\u201e<br>Basic EAE study - Reduced clinical scores significantly (p&lt;0.001) - Reduced IFN-\u03b3, IL-6, IL-17 (pro-inflammatory) - Increased TGF-\u03b2, IL-4, IL-10 (anti-inflammatory) - Reduced leukocyte infiltration into the CNS<\/li>\n\n\n\n<li><strong>Ahmadi M et al. (2023)<\/strong> - <br>\u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S2211034822009750\" target=\"_blank\" rel=\"noreferrer noopener\">Effect of Carvacrol on histological analysis and expression of genes involved in an animal model of multiple sclerosis<\/a>\u201e<br>Gene expression study - Reduced NF-\u03baB, IL-1 and IL-17 gene expression significantly - Increased MBP (myelin basic protein) and OLIG2 (oligodendrocyte marker) - Promoted remyelination - Histology showed less demyelination and infiltrates<\/li>\n\n\n\n<li><strong>Fahad Khan Thareen (2024)<\/strong><br>Review: \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11721141\/\" target=\"_blank\" rel=\"noreferrer noopener\">Carvacrol Essential Oil as a Neuroprotective Agent<\/a>\u201e<br>Comprehensive overview: 59 studies analyzed (2009-2024) - Neuroprotective in MS, Alzheimer's, Parkinson's, ischemia, epilepsy - Has antioxidant, anti-inflammatory, immunomodulatory effects - Regulates intracellular Ca2+ homeostasis<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lavendel\"><\/span>Lavender<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Mode of action dose-dependent!<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lavender counteracts the consequences of permanent stress, thus the inflammation-promoting <em>Cortisol<\/em>release, which not only irritates the immune system but also provokes flare-ups. It lowers cortisol levels and thus has an anti-inflammatory effect.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It promotes sleep and supports the regeneration of the immune system during the deep sleep phases: inflammation is reduced and tissue damage is repaired.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The nervous system is calmed, activates the <em>Parasympathetic nervous system<\/em>, which triggers the rest and digestion mode to promote healing processes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lavender also blocks inflammatory messengers on a cellular basis and therefore has an anti-inflammatory effect,<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lavender is therefore suitable as an accompanying therapy for<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>all autoimmune diseases<\/li>\n\n\n\n<li>relapses triggered by stress<\/li>\n\n\n\n<li>chronic diseases<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">as the following studies also confirm:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Horvath G et al. (2021)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8611982\/\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-inflammatory effect of lavender (Lavandula angustifolia Mill.) essential oil prepared during different plant phenophases on THP-1 macrophages<\/a>\u201e<br>Linalool and lavender oil reduced <em>IL-6, IL-8, IL-1\u03b2, TNF-\u03b1<\/em> Significant - Similar to <em>NF\u03baB inhibitors<\/em> - Best effect: oil from the beginning of the flowering period<\/li>\n\n\n\n<li><strong>Silva GL et al. (2015)<\/strong> - \u201e<a href=\"https:\/\/www.scielo.br\/j\/aabc\/a\/PxSc9T7wm4fXK4KCXrvWwWy\/?lang=en\" target=\"_blank\" rel=\"noreferrer noopener\">Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil<\/a>\u201e<br>In vivo anti-inflammatory - Carrageenan-induced pleurisy: lavender oil reduced inflammation - Croton oil-induced edema: effect similar to <em>Dexamethasone<\/em> - Formalin test: pain relief similar to <em>Tramadol<\/em><\/li>\n\n\n\n<li><strong>Cardia GFE et al. (2018)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5878871\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effect of Lavender<em>&nbsp;(Lavandula angustifolia)<\/em>&nbsp;Essential Oil on Acute Inflammatory Response<\/a>\u201e<br>Dose dependence in the mode of action: <strong>Low doses<\/strong>Anti-inflammatory (reduced NO, MPO, edema) - <strong>High doses<\/strong>: Irritant (pro-inflammatory) - Mechanism: <em>Prostanoids, cytokines, NO, histamine<\/em><\/li>\n\n\n\n<li><strong>Gostner JM et al. (2014)<\/strong> - \u201e<a href=\"https:\/\/link.springer.com\/article\/10.1186\/1472-6882-14-503\" target=\"_blank\" rel=\"noreferrer noopener\">Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC<\/a>\u201e<br>Inhibits IDO (<em>Indoleamine 2,3-dioxygenase<\/em>) - important for autoimmunity - Reduced <em>Tryptophan breakdown<\/em> and <em>Neopterin<\/em> (immune activation marker) - Relevant for chronic immune activation, autoimmune syndromes<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Eukalyptus\"><\/span>Eucalyptus<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The main active ingredient in eucalyptus <em>1,8-Cineole<\/em> activates macrophages, the scavenger cells of the immune system. Their task is to clear up cell debris, dead cells and inflammatory substances. The property of eucalyptus is the activation of macrophages in the aforementioned direction, whereas in autoimmune diseases macrophages attack healthy cells and tissue in overzealousness, which is counterproductive.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Swelling is reduced, which reduces pressure, thus ensuring better mobility in the joints and reducing pain, but also by inhibiting pain messengers.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">At the same time, the improvement in well-being has a mood-enhancing effect, which reduces depression - especially in the case of chronic pain.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Eucalyptus thus proves to be<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Rheumatoid arthritis<\/li>\n\n\n\n<li>Autoimmune diseases of the respiratory tract<\/li>\n\n\n\n<li>Joint pain<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">effective according to the following studies:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Yin C et al (2020)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7161556\/\" target=\"_blank\" rel=\"noreferrer noopener\">Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis<\/a>\u201e<br>Gouty arthritis mouse model - Eucalyptol reduced pain and swelling in a dose-dependent manner - Efficacy comparable to indomethacin (NSAID) - Inhibited NLRP3 inflammasome activation - Reduced oxidative stress (increased SOD, CAT, GPx; lowered ROS) - Suppressed TRPV1 overexpression (pain receptor) - Mechanism: Antioxidant effect \u2192 inhibits NLRP3 \u2192 reduces IL-1\u03b2<\/li>\n\n\n\n<li><strong>Juergens UR et al. (2004)<\/strong> - \u201eI<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15477123\/\" target=\"_blank\" rel=\"noreferrer noopener\">nhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes<\/a>\u201e<br>Fundamental immune cell study - <strong>Human lymphocytes:<\/strong> 1.5 \u03bcg\/ml (10-\u2075M) significantly inhibited: TNF-\u03b1 by 92%, IL-1\u03b2 by 84%, IL-4 by 70%, IL-5 by 65% - <strong>Human monocytes:<\/strong> Same concentration inhibited TNF-\u03b1 by 99%, IL-1\u03b2 by 84%, IL-6 by 76%, IL-8 by 65% - Mechanism: Suppression of NF-\u03baB - Therapeutic concentrations without cytotoxicity<\/li>\n\n\n\n<li><strong>Greiner JFW et al. (2013)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0167488913002747\" target=\"_blank\" rel=\"noopener\">1,8-Cineole inhibits nuclear translocation of NF-\u03baB p65 and NF-\u03baB-dependent transcriptional activity<\/a>\u201e<br>Molecular NF-\u03baB mechanism - 1,8-cineole blocks NF-\u03baB p65 translocation into the cell nucleus - Inhibits NF-\u03baB-dependent transcriptional activity - Increases I\u03baB\u03b1 level in a dose-dependent manner - Acts on MAPK pathway<\/li>\n\n\n\n<li><strong>Khan A et al (2014)<\/strong> - \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24379109\/\" target=\"_blank\" rel=\"noreferrer noopener\">1,8-Cineole (Eucalyptol) Mitigates Inflammation in Amyloid Beta Toxicated PC12 Cells<\/a>\u201e<br>Neuroinflammation (relevance for MS) - Reduced TNF-\u03b1, IL-1\u03b2, IL-6 in neuronal cells - Inhibited NF-\u03baB activation - Antioxidant effect (increased SOD, CAT, GSH) - Relevant for neurodegenerative autoimmune diseases<\/li>\n\n\n\n<li><strong>Venkataraman B et al. (2023)<\/strong> - \u201e<a href=\"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6160\" target=\"_blank\" rel=\"noreferrer noopener\">Molecular docking identifies 1,8-cineole (eucalyptol) as a novel PPAR\u03b3 agonist that alleviates colon inflammation<\/a>\u201e<br>PPAR\u03b3 agonist in colitis - 1,8-cineole binds to PPAR\u03b3 (like thiazolidinediones in diabetes) - Reduced colitis symptoms in DSS-induced model - Reduced MPO activity, IL-6, TNF-\u03b1, iNOS - Increased IL-10 (anti-inflammatory) - Mechanism<strong>:<\/strong> PPAR\u03b3 activation \u2192 inhibits NF-\u03baB<\/li>\n\n\n\n<li><strong>Jun YS et al. (2013)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3703330\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effect of Eucalyptus Oil Inhalation on Pain and Inflammatory Responses after Total Knee Replacement<\/a>\u201e<br>Clinical study in knee replacement - Eucalyptus inhalation after TKR significantly reduced pain - Lowered CRP (C-reactive protein) - Inflammation markers - Reduced blood pressure (parasympathetic activation) - 1,8-cineole inhibits cytokine secretion by T lymphocytes - Suppresses edema formation<\/li>\n\n\n\n<li><strong>Brown SK et al (2017)<\/strong> - Review: \u201e<a href=\"https:\/\/www.researchgate.net\/publication\/318342501_18-cineole_An_Underappreciated_Anti-inflammatory_Therapeutic\" target=\"_blank\" rel=\"noreferrer noopener\">1,8-cineole: An Underappreciated Anti-inflammatory Therapeutic<\/a>\u201e<br>Multiple clinical studies demonstrate potent anti-inflammatory activity - Use in arthritis, type 2 diabetes, cardiovascular disease - As primary therapy or adjuvant to synthetic drugs - Safe profile, low side effects<\/li>\n\n\n\n<li><strong>Salvatori G et al. (2023)<\/strong> - \u201e<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2023\/2582698\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-Inflammatory and Antimicrobial Effects of Eucalyptus spp. Essential Oils<\/a>\u201e<br>Antimicrobial and anti-inflammatory - 1,8-cineole inhibits arachidonic acid pathway \u2192 inhibits inflammatory mediators - Common mechanism with glucocorticoids - \u03b1-pinene (also in eucalyptus): Anti-inflammatory in osteoarthritis, antioxidant - Eucalyptol inhibits TNF, IL-1, leukotrienes, thromboxane<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nelke\"><\/span>Carnation<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Cave<\/strong>Clove oil can increase the effect of blood thinners!<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Eugenol, the main active ingredient in clove oil, blocks the enzyme COX-2, which produces inflammatory substances (prostaglandins), as well as NF-\u03baB, both of which are responsible for the usual symptoms of inflammation, such as redness, pain, swelling, etc.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It interrupts the signaling pathways of the causative substances at several points and is therefore effective for<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>severe joint inflammation<\/li>\n\n\n\n<li>acute pain<\/li>\n\n\n\n<li>systemic inflammations<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">as the following studies confirm:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Kang HJ et al. (2024)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1567576923018064\" target=\"_blank\" rel=\"noreferrer noopener\">Eugenol alleviates the symptoms of experimental autoimmune encephalomyelitis in mice by suppressing inflammatory responses<\/a>\u201e<br>Multiple sclerosis EAE model - MOG-induced EAE in C57BL\/6 mice - Daily oral administration of eugenol significantly reduced clinical symptoms - Inhibited immune cell infiltration and proinflammatory mediators - Histology: Reduced inflammation and demyelination in the spinal cord - Mechanism: Anti-inflammatory, antioxidant, neuroprotective<\/li>\n\n\n\n<li><strong>Ferrari JG et al. (2025)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12290672\/\" target=\"_blank\" rel=\"noreferrer noopener\">Antioxidant and Anti-inflammatory Activity of Eugenol, Bis-eugenol, and Clove Essential Oil<\/a>\u201e<br>TLR4\/NF-\u03baB pathway - In vitro study on LPS-stimulated macrophages - Eugenol and clove oil significantly reduced TLR4 levels - NF-\u03baB activation inhibited - <strong>Bis-eugenol (dimeric form):<\/strong> Only substance that simultaneously suppressed TLR4\/NF-\u03baB, upregulated NRF2 (antioxidant) and increased IL-10 (anti-inflammatory) - DPPH radical scavenging activity: ~80% at 25 \u03bcg\/mL - TNF-\u03b1 level decreased at all concentrations<\/li>\n\n\n\n<li><strong>Barboza JN et al (2018)<\/strong> - Review: \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6217746\/\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-inflammatory Potential and Antioxidant Profile of Eugenol<\/a>\u201e<br>Inhibits NF-\u03baB signaling pathway (p50\/p65 phosphorylation) - Reduces COX-2, TNF-\u03b1, IL-6, IL-1\u03b2, NO - Improves antioxidant enzymes: SOD, CAT, GPx, GST - In lung injury: Reduced neutrophil infiltration, TNF-\u03b1, NF-\u03baB - Dosage: 10.7 mg\/kg\/day in rats showed optimal effect<\/li>\n\n\n\n<li><strong>Daniel AN et al. (2009)<\/strong> - \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22420667\/\" target=\"_blank\" rel=\"noreferrer noopener\">Clove and eugenol in noncytotoxic concentrations exert immunomodulatory\/anti-inflammatory action<\/a>\u201e<br>Immunomodulation - Macrophages incubated with clove\/eugenol (24h) - Clove oil (100 \u03bcg\/well) inhibited IL-1\u03b2, IL-6, IL-10 - Eugenol (50-100 \u03bcg\/well) inhibited IL-6 and IL-10 - Acted preventively and therapeutically against LPS stimulation - Mechanism: suppression of NF-\u03baB by eugenol<\/li>\n\n\n\n<li><strong>Khalil AA et al. (2021)<\/strong> - Review: \u201eBiological Properties of Eugenol\u201c<br>Inhibits 5-LOX and COX-2 (dual action!) - Prevents neutrophil\/macrophage chemotaxis - Inhibits prostaglandin and leukotriene synthesis - Eugenol dimers show chemopreventive properties - Could replace NSAIDs in osteoarthritis and inflammatory diseases - Safe dose: 2.5 mg\/kg body weight<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Teebaum\"><\/span>Tea tree<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Terpinen-4-ol, the main active ingredient in tea tree oil, calms monocytes and macrophages, both immune cells that are overactive in many autoimmune diseases: They migrate en masse into the tissue, releasing large quantities of inflammatory messengers and summoning further immune cells. Tea tree oil interrupts this self-reinforcing inflammatory cycle.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In addition to reducing inflammatory messengers such as TNF-\u03b1, IL-1\u03b2 and other aggressive signaling molecules, its strong antimicrobial effect (bacteria, viruses, fungi) reduces autoimmune relapses and modulates not only monocytes but also leukocytes, the white blood cells, which has a broad spectrum of efficacy in, among others<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Skin autoimmune diseases<\/li>\n\n\n\n<li>systemic inflammations<\/li>\n\n\n\n<li>as a broad immune module<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">as these studies show:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Hart PH et al (2000)<\/strong> - \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11131302\/\" target=\"_blank\" rel=\"noreferrer noopener\">Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes<\/a>\u201e<br>Basic human monocyte study - <strong>Human peripheral blood monocytes<\/strong> (not animal model) - Water soluble components at 0.125% reduced: TNF-\u03b1 by ~50%, IL-1\u03b2 by ~50%, IL-10 by ~50%, PGE2 by ~30% - Only terpinen-4-ol (not \u03b1-terpineol or 1,8-cineole) was active - Suppression of all five mediators: TNF-\u03b1, IL-1\u03b2, IL-8, IL-10, PGE2<\/li>\n\n\n\n<li><strong>Nogueira MNM et al. (2014)<\/strong> - \u201eTerpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1\u03b2, IL-6 and IL-10 on human macrophages\u201c<br>Mechanism study - U937 macrophages (human cell line) - TTO and terpinen-4-ol significantly reduced IL-1\u03b2, IL-6, IL-10 - Mechanism<strong>:<\/strong> Interference with NF-\u03baB, p38 or ERK MAPK pathways - Effect NOT through NF-\u03baB\/p38 activation changes, but downstream - Effective on TLR4 and TLR2\/TLR4 activation<\/li>\n\n\n\n<li><strong>Carson CF et al. (2006)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1360273\/\" target=\"_blank\" rel=\"noreferrer noopener\">Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties<\/a>\u201e<br>Comprehensive review - Systematic overview of all immunomodulatory effects - TTO inhibits TNF-\u03b1, IL-1\u03b2, IL-10 (50%) and PGE2 (30%) in human monocytes - Terpinen-4-ol modulates edema formation after histamine injection - Reduces erythema in nickel-induced contact hypersensitivity - Topical application modulates contact hypersensitivity response in mice<\/li>\n\n\n\n<li><strong>Ninomiya K et al. (2012)<\/strong> - \u201e<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/36\/5\/36_b13-00033\/_html\/-char\/en\" target=\"_blank\" rel=\"noreferrer noopener\">Suppression of inflammatory reactions by terpinen-4-ol in a murine model of oral candidiasis<\/a>\u201e<br>Oral candidiasis model - Terpinen-4-ol (40mg\/mL, 50\u00b5L orally) 3h after Candida infection - Suppressed myeloperoxidase activity significantly - Reduced Macrophage Inflammatory Protein-2 (MIP-2) - In vitro: 800\u00b5g\/mL inhibited cytokine production of cultured macrophages<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Thymian\"><\/span>Thyme<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Cave<\/strong>Note chemotype!<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As explained in the introduction with regard to chemotypes, the curvature is different. While thyme <em>Linalool<\/em> is indicated for autoimmune diseases with its calming and modulating effect, thyme has a <em>Thymol<\/em> with its intensive immunostimulating properties is counterproductive and can provoke relapses, inflammation and pain.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study situation on thyme:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Gholijani N et al. (2015)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4708037\/\" target=\"_blank\" rel=\"noreferrer noopener\">Modulation of Cytokine Production and Transcription Factors Activities in Human Jurkat T Cells by Thymol and Carvacrol<\/a>\u201e<br>T-cell modulation (most important study for autoimmunity) - <strong>Human T cells<\/strong> (Jurkat T cell line) - thymol and carvacrol at 25 \u00b5g\/ml significantly reduced IL-2: from 119.4\u00b18 to 66.9\u00b16.4 pg\/ml (thymol) and 32.3\u00b13.6 pg\/ml (carvacrol), IFN-\u03b3: from 423.7\u00b119.7 to 311.9\u00b111.6 pg\/ml - Mechanism<strong>:<\/strong> Reduced NFAT-2 to 44.2% (thymol) and 91.4% (carvacrol) - c-Fos to 31.2% (thymol) and 27.6% (carvacrol) - NFAT-2 and AP-1 are critical for T cell activation in autoimmunity<\/li>\n\n\n\n<li><strong>Amirghofran Z et al. (2015)<\/strong> - \u201e<a href=\"https:\/\/www.tandfonline.com\/doi\/10.3109\/1547691X.2015.1029145?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubmed#d1e252\" target=\"_blank\" rel=\"noreferrer noopener\">Modulatory effects of thymol and carvacrol on inflammatory transcription factors in lipopolysaccharide-treated macrophages<\/a>\u201e<br>Macrophage study - J774.1 Mouse macrophages, LPS-stimulated - Carvacrol significantly reduced IL-1\u03b2 and TNF-\u03b1 (protein + mRNA) - Thymol significantly reduced IL-1\u03b2 - <strong>Western Blot:<\/strong> Both reduced c-Fos, NFAT-1, NFAT-2 - Carvacrol lowered phospho-SAPK\/JNK and phospho-STAT3 - Modulated JNK, STAT-3, AP-1, NFATs<\/li>\n\n\n\n<li><strong>Horvath G et al. (2022)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9311800\/\" target=\"_blank\" rel=\"noreferrer noopener\">Antioxidant and Anti-Inflammatory Effects of Thyme (Thymus vulgaris L.) Essential Oils<\/a>\u201e<br>Phenophase study - TEO from the beginning of flowering inhibited IL-6, IL-8, IL-1\u03b2, TNF-\u03b1 potently - TEO from the end of flowering less effectively - <strong>Not just thymol, but synergism of all components<\/strong> Responsible - Increased CAT and SOD activity (antioxidant)<\/li>\n\n\n\n<li><strong>Fachini-Queiroz FC et al (2012)<\/strong> - \u201e<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2012\/657026\" target=\"_blank\" rel=\"noreferrer noopener\">Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response<\/a>\u201e<br>In vivo study - TEO and carvacrol inhibited inflammatory edema and leukocyte migration - <strong>Important:<\/strong> Thymol showed <strong>irritative effect<\/strong> (chemoattractant) - Carvacrol was responsible for anti-inflammatory effects - Carvacrol (10mg\/ear topical) reduced edema<\/li>\n\n\n\n<li><strong>Gago C. et al. (2025)<\/strong> - \u201e<a href=\"https:\/\/www.mdpi.com\/1420-3049\/30\/11\/2450\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-Inflammatory Activity of Thymol and Thymol-Rich Essential Oils<\/a>\u201e<br>Review - Thymol (50 \u00b5g\/mL) inhibited TLR4\/MyD88\/NF-\u03baB\/IL-1\u03b2 signaling - Prevented cell aggregation, reduced necroptosis and pyroptosis - Standardized extract (0.3% thymol) in HBEpC\/HTEpC: Reduced NF-\u03baB p65 and p52, lowered IL-1\u03b2, IL-8, Muc5ac - Thymol: FDA \u201egenerally recognized as safe\u201c<\/li>\n\n\n\n<li><strong>Waheed F et al. (2024)<\/strong> - \u201e<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/fsn3.4563\" target=\"_blank\" rel=\"noreferrer noopener\">Phytochemical Profiling and Therapeutic Potential of Thyme (Thymus spp.): A Medicinal Herb<\/a>\u201e<br>Comprehensive Review - Thymol reduces MAPK and NF-\u03baB signaling pathways - <strong>Immunomodulating effects in autoimmune diseases<\/strong> - Can restore immune balance in dysregulated immune responses - Promising natural remedy for immunological disorders<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Rosmarin\"><\/span>Rosemary<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Improves blood circulation and thus brings more oxygen and nutrients to inflamed areas, as inflamed tissue has an increased metabolism and needs more \u201efuel\u201c to heal. At the same time, waste products and inflammatory mediators need to be removed, which build up when circulation is poor, hindering healing and causing pain.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It therefore promotes healing processes thanks to improved blood circulation, faster removal of inflammatory substances and an intensified supply of repair material (amino acids, vitamins, minerals).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Muscle and joint pain is alleviated. The improved circulation relaxes hardened muscles, reduces stiffness and promotes mobility.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Rosemary activates the mind, which is particularly important in cases of chronic fatigue, because \u201e<em>Fatigue<\/em>\u201c (extreme exhaustion) is a major symptom of autoimmune diseases. The invigorating effect on the brain and nervous system also has an anti-inflammatory effect by blocking the inflammatory pathways (NF-\u03baB, COX-2).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Accordingly, rosemary is helpful for<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Rheumatoid arthritis<\/li>\n\n\n\n<li>Muscle stiffness<\/li>\n\n\n\n<li>Chronic tiredness (fatigue)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">as the following studies show:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Beninc\u00e1 JP et al. (2011)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0308814610007661\" target=\"_blank\" rel=\"noreferrer noopener\">Analysis of the anti-inflammatory properties of Rosmarinus officinalis L. in mice<\/a>\u201e<br>Colitis model (relevant for IBD) - Rosemary essential oil in the diet reduced TNBS colitis - Preventive administration: reduced damage scores, wet weight, MPO activity - \u03b1-pinene and borneol (further components) enhanced the effect - \u03b1-pinene inhibits NF-\u03baB translocation in LPS-stimulated THP-1 cells - 1,8-cineole inhibits prostaglandin\/cytokine formation<\/li>\n\n\n\n<li><strong>Belkhodja H et al. (2021)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7871606\/\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-osteoarthritis potential of peppermint and rosemary essential oils in a nanoemulsion form<\/a>\u201e<br>Osteoarthritis MIA model - Rosemary nanoemulsion significantly reduced osteoarthritis score - Reduced cartilage degradation and joint inflammation - Histology: Less mononuclear cell infiltration, thicker cartilage - Rosemary reduced migrating cells and inflammatory exudate - <strong>Effective in formalin test, writhing test, paw edema test<\/strong><\/li>\n\n\n\n<li><strong>Borges RS et al (2019)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874118314107\" target=\"_blank\" rel=\"noreferrer noopener\">Rosmarinus officinalis essential oil: Phytochemistry, anti-inflammatory activity, and mechanisms<\/a>\u201e<br>Review - Main components: 1,8-cineole, \u03b1-pinene, camphor - Mechanisms: NF-\u03baB inhibition, arachidonic acid cascade suppression - Antioxidant activity prevents ROS damage - Smooth muscle relaxation (important in respiratory diseases) - Low toxicity<\/li>\n\n\n\n<li><strong>Khalil DY &amp; Hassan OM (2024)<\/strong> - \u201e<a href=\"https:\/\/www.publishing.emanresearch.org\/Journal\/Abstract\/angiotherapy-849609\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-inflammatory and Antioxidant Activity of Rosemary Essential Oil<\/a>\u201e<br>Iraqi study - GC-MS: eucalyptol (34,25%), \u03b1-pinene (20,98%), camphor (13,75%) - protein denaturation assay: significant anti-inflammatory effect - <strong>Inhibition rate of free radicals: 87.45%<\/strong> - At 50mg\/mL comparable to diclofenac sodium - High antioxidant activity, comparable to Trolox<\/li>\n\n\n\n<li><strong>Zuzarte M et al. (2011)<\/strong> - \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21919504\/\" target=\"_blank\" rel=\"noreferrer noopener\">Chemical composition and antifungal activity of the essential oils of Lavandula viridis, Lavandula stoechas subsp. lusitanica, and Rosmarinus officinalis<\/a>\u201e<br>Anti-inflammatory and antioxidant study - Rosemary oil showed strong antioxidant activity - Inhibited lipid peroxidation - Protected against oxidative damage in cells<\/li>\n\n\n\n<li><strong>Ra\u0161kovi\u0107 A et al. (2014)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0378874114000725\" target=\"_blank\" rel=\"noreferrer noopener\">Antioxidant and anti-inflammatory activity of rosemary (Rosmarinus officinalis L.) essential oil<\/a>\u201e<br>In vivo inflammation models - Carrageenan-induced paw edema: Dose-dependent inhibition - Formalin test: Significant analgesic effect - Both test phases (neurogenic and inflammatory) affected - DPPH radical scavenging activity: IC50 = 8.7 mg\/mL - Comparable to synthetic antioxidants<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zitrusole_Orange_Zitrone_Bergamotte\"><\/span>Citrus oils (orange, lemon, bergamot)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The main effect of citrus oils is on a psychological level and are therefore also immunomodulatory: anyone suffering from depression due to chronic pain, for example, also experiences a weakening of their immune system. A vicious circle that citrus oils are able to break.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">By using the <em>Serotonin<\/em>- and <em>Dopamine<\/em>-release in the brain, they noticeably lift the mood, which reduces anxiety and depression when fear of relapses, worry about the future and frustration about restrictions no longer dominate.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">They support the immune system indirectly by reducing stress, because a good mood means fewer stress hormones and this in turn means better immune regulation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The antimicrobial effect of <em>Limes<\/em> also acts directly against bacteria and viruses, which can prevent infections that may trigger flare-ups.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lemon oils are therefore effective for<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Depression resulting from chronic illnesses<\/li>\n\n\n\n<li>Stress management<\/li>\n\n\n\n<li>and as a pleasant addition to mixtures<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">according to the results of the following studies:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Amorim JL et al (2016)<\/strong> - \u201e<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0153643\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-Inflammatory Properties and Chemical Characterization of the Essential Oils of Four Citrus Species<\/a>\u201e<br>Four citrus species in comparison - C. limon, C. aurantifolia, C. limonia showed anti-inflammatory effects - Reduced cell migration, cytokine production, protein extravasation (carrageenan) - Pure limonene showed the same effects as the complete oils - limonene (31.1-65.7%), \u03b2-pinene (5.1-13.1%), \u03b3-terpinene (10.8-12.2%) - Limonene inhibits cell migration and cytokine production<\/li>\n\n\n\n<li><strong>Kummer R et al. (2013)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3671226\/\" target=\"_blank\" rel=\"noreferrer noopener\">Evaluation of Anti-Inflammatory Activity of Citrus latifolia Tanaka Essential Oil and Limonene<\/a>\u201e<br>Citrus latifolia\/limonene - Limonene (62% of the oil) reduced neutrophil migration to fMLP and LTB4 - 500mg\/kg limonene significantly reduced TNF-\u03b1 levels - Mechanism: inhibition of proinflammatory mediators in exudate - inhibition of leukocyte chemotaxis - In vitro: 1, 3, 10\u00b5g\/mL limonene effective<\/li>\n\n\n\n<li><strong>Yoon WJ et al (2010)<\/strong> - \u201e<a href=\"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/j.1750-3841.2010.01541.x\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-inflammatory Effects of Limonene from Yuzu (Citrus junos Tanaka) Essential Oil on Eosinophils<\/a>\u201e<br>Eosinophil study - Limonene (7.34mM) inhibited ROS production in eotaxin-stimulated HL-60 cells - 14.68mM decreased MCP-1 production via NF-\u03baB activation - Comparable to proteasome inhibitor MG132 - Inhibited cell chemotaxis p38 MAPK-dependently (like SB203580) - Potential for asthma treatment via cytokine\/ROS inhibition<\/li>\n\n\n\n<li><strong>Hirota R et al. (2010)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0278691513002007\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-inflammatory effect of essential oil through blocking JNK, ERK and NF-\u03baB pathways<\/a>\u201e<br>Fingered Citron (C. medica) - Limonene (52,44%) + \u03b3-Terpinene (28,41%) = 98,97% of oil - Inhibited NO and PGE2 by suppression of iNOS and COX-2 - Suppressed TNF-\u03b1, IL-1\u03b2, IL-6 - Mechanism<strong>:<\/strong> NF-\u03baB activation prevented, I\u03baB-\u03b1 phosphorylation inhibited - Additionally: JNK and ERK pathway inhibition<\/li>\n\n\n\n<li><strong>Lee GH et al. (2023)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10301132\/\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-Inflammatory Effects of Essential Oils from the Peels of Citrus Cultivars<\/a>\u201e<br>21 Citrus cultivars screening - C. japonica and C. maxima showed superior anti-inflammatory activity - Inhibited inflammatory mediator + proinflammatory cytokine expression - Active components: \u03b1-pinene, myrcene, limonene, \u03b2-ocimene, linalool, \u03b1-terpineol - <strong>\u03b1-Terpineol showed the strongest anti-inflammatory effect<\/strong> - Limonene was the main component in all 21 oils<\/li>\n\n\n\n<li><strong>El Omari N et al. (2024)<\/strong> - \u201e<a href=\"https:\/\/www.mdpi.com\/1424-8247\/17\/12\/1652\" target=\"_blank\" rel=\"noreferrer noopener\">Chemical Composition and Assessment of Anti-inflammatory, Antioxidant Activities of Citrus sinensis Essential Oil<\/a>\u201e<br>Citrus sinensis\/Limonene Review - Limonene (70,15%) as main component - Dose-dependent NO and PGE2 reduction in RAW 264.7 macrophages - Elastase inhibition (IC50 = 65.72\u00b5g\/mL), tyrosinase (IC50 = 102\u00b5g\/mL) - Better than quercetin standard - Dermatoprotective - relevant for psoriasis, skin autoimmunity<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ol-Kombinationen_fur_verschiedene_Autoimmunerkrankungen\"><\/span>Oil combinations for various autoimmune diseases<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Multiple_Sklerose_MS\"><\/span>Multiple sclerosis (MS)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">3 drops <strong>Copaiba<\/strong> (nerve protection, remyelination)<br>2 drops <strong>Incense<\/strong> (anti-inflammatory)<br>2 drops <strong>Oregano<\/strong> (T-cell balance)<br>1 drop <strong>Lavender<\/strong> (Stress)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In 30ml <strong>Carrier oil<\/strong> (e.g. jojoba oil)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Application:<\/strong><br>Massage into the neck and spine twice a day<br>Additional inhalation (1-2 drops on a handkerchief)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Rheumatoide_Arthritis\"><\/span>Rheumatoid arthritis<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">3 drops <strong>Incense<\/strong> (cartilage protection, leukotriene inhibition)<br>2 drops <strong>Eucalyptus<\/strong> (macrophage modulation)<br>2 drops <strong>Rosemary<\/strong> (blood circulation)<br>1 drop <strong>Carnation<\/strong> (COX-2 inhibition)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In 30ml <strong>Carrier oil<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Application:<\/strong><br>Apply directly to affected joints<br>Massage in gently<br>2-3x daily<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Morbus_Crohn_Colitis\"><\/span>Crohn's disease \/ colitis<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">3 drops <strong>Incense<\/strong> (specific for intestine)<br>2 drops <strong>Lavender<\/strong> (gut-brain axis, stress)<br>2 drops <strong>Thyme Linalool <\/strong>(gentle antimicrobial effect)<br>1 drop <strong>Bergamot<\/strong> (mood)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In 30ml <strong>Carrier oil<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Application:<\/strong><br>Massage onto the abdomen in a clockwise direction<br>For cramps as a warm compress<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lupus_Systemischer_Lupus_Erythematodes\"><\/span>Lupus (Systemic Lupus Erythematosus)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">3 drops <strong>Copaiba<\/strong> (CB2 system)<br>2 drops <strong>Lavender<\/strong> (oxidative stress)<br>2 drops <strong>Oregano<\/strong> (T-cell balance)<br>1 drop <strong>Tea tree oil<\/strong> (monocyte modulation)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In 30ml <strong>Carrier oil<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Application:<\/strong><br>Especially joints and painful areas<br>Full body massage (avoid sun-exposed areas)<\/p>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wechselwirkungen_mit_Biologika\"><\/span>Interactions with biologics<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_sind_Biologika\"><\/span>What are biologics?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Biologics are biotechnologically produced drugs that specifically intervene in the immune system. They are used to treat moderate to severe autoimmune diseases.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Hauptklassen_der_Biologika\"><\/span>Main classes of biologics<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TNF-%CE%B1-Inhibitoren\"><\/span><strong>TNF-\u03b1 inhibitors<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Block tumor necrosis factor-alpha, a cytokine that promotes inflammation, e.g.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Infliximab (Remicade)<\/li>\n\n\n\n<li>Adalimumab (Humira)<\/li>\n\n\n\n<li>Etanercept (Enbrel)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Use for rheumatoid arthritis, Crohn's disease, ulcerative colitis, psoriasis<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Interleukin-Inhibitoren\"><\/span><strong>Interleukin inhibitors<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Block specific interleukins (IL-1, IL-6, IL-12\/23, IL-17, IL-23).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Tocilizumab (IL-6)<\/li>\n\n\n\n<li>Ustekinumab (IL-12\/23)<\/li>\n\n\n\n<li>Secukinumab (IL-17)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Use for rheumatoid arthritis, psoriasis, psoriatic arthritis<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"B-Zell-Depletoren\"><\/span><strong>B-cell depletors<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Reduce B lymphocytes that produce antibodies.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Rituximab (MabThera)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Use in rheumatoid arthritis, certain vasculitides<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"T-Zell-Kostimulationshemmer\"><\/span><strong>T-cell costimulation inhibitors<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Block the activation of T cells.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Abatacept (Orencia)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Use for rheumatoid arthritis<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Integrin-Antagonisten\"><\/span><strong>Integrin antagonists<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Prevent the migration of immune cells into inflammatory foci.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vedolizumab (Entyvio)<\/li>\n\n\n\n<li>Natalizumab (Tysabri)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Use in chronic inflammatory bowel disease, multiple sclerosis<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Potenzielle_additive_entzundungshemmende_Effekte\"><\/span>Potential additive anti-inflammatory effects<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Essential oil<\/th><th>Main active ingredients<\/th><th>Biologics class<\/th><th>Possible synergy mechanism<\/th><th>Potential advantages<\/th><\/tr><\/thead><tbody><tr><td>Frankincense (Boswellia)<\/td><td>Boswellic acids<\/td><td>TNF-\u03b1 inhibitors<\/td><td>Inhibition of leukotrienes + TNF-\u03b1 blockade<\/td><td>Increased inhibition of inflammation<\/td><\/tr><tr><td>Turmeric (essential oil)<\/td><td>Turmeron, ar-Turmeron<\/td><td>IL-6 inhibitors<\/td><td>NF-\u03baB inhibition + IL-6 blockade<\/td><td>Reduced systemic inflammation<\/td><\/tr><tr><td>Ginger<\/td><td>Gingerols, Shogaols<\/td><td>TNF-\u03b1 inhibitors<\/td><td>COX-2 inhibition + TNF-\u03b1 reduction<\/td><td>Pain relief, reduction of inflammation<\/td><\/tr><tr><td>Lavender<\/td><td>Linalool, linalyl acetate<\/td><td>All classes<\/td><td>Stress reduction, cortisol modulation<\/td><td>Improved disease control through stress management<\/td><\/tr><tr><td>Peppermint<\/td><td>Menthol, menthone<\/td><td>TNF-\u03b1 inhibitors<\/td><td>Local pain relief + systemic anti-inflammation<\/td><td>Symptom relief<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Immunmodulatorische_Effekte\"><\/span>Immunomodulatory effects<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Essential oil<\/th><th>Immune effect<\/th><th>Possible synergy with biologics<\/th><th>Hints<\/th><\/tr><\/thead><tbody><tr><td>Tea tree oil<\/td><td>Antimicrobial, immunostimulant<\/td><td>Potentially counterproductive in immunosuppression<\/td><td>Caution with severe immunosuppression<\/td><\/tr><tr><td>Thyme<\/td><td>Antimicrobial, immunostimulant<\/td><td>Potentially protective against infections<\/td><td>Could reduce the risk of infection<\/td><\/tr><tr><td>Oregano<\/td><td>Highly antimicrobial<\/td><td>Potentially protective in immunosuppression<\/td><td>Only highly diluted and with caution<\/td><\/tr><tr><td>Camomile<\/td><td>Anti-inflammatory, calming<\/td><td>Additive anti-inflammatory effect<\/td><td>Well tolerated, no immune stimulation<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Theoretische_Risiken\"><\/span>Theoretical risks<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Verstarkte_Immunsuppression\"><\/span><strong>Increased immunosuppression<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Biologicals specifically suppress parts of the immune system. Some essential oils could enhance this effect:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risk scenario:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Mechanism:<\/strong> Additive immunosuppressive effect<\/li>\n\n\n\n<li><strong>Oils concerned:<\/strong> Frankincense, myrrh (high doses), turmeric<\/li>\n\n\n\n<li><strong>Consequence:<\/strong> Increased risk of infection, delayed wound healing<\/li>\n\n\n\n<li><strong>Clinical relevance:<\/strong> Probably low with topical application, higher with oral administration<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Erhohtes_Infektionsrisiko\"><\/span><strong>Increased risk of infection<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Biologics increase the risk of bacterial, viral and fungal infections, especially tuberculosis and opportunistic infections.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Critical considerations:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Immunostimulating oils:<\/strong> Could theoretically weaken the effect of biologics (e.g. tea tree oil, oregano, thyme)<\/li>\n\n\n\n<li><strong>Antimicrobial oils:<\/strong> Could have a protective effect, but cannot replace medical infection prophylaxis<\/li>\n\n\n\n<li><strong>Paradox:<\/strong> Excessive immune stimulation could exacerbate autoimmune reactions<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Allergische_Reaktionen_und_Hautreaktionen\"><\/span><strong>Allergic reactions and skin reactions<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Patients on biologics often have more sensitive skin and an altered immune system.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Contact dermatitis due to essential oils<\/li>\n\n\n\n<li>Photosensitization (citrus oils)<\/li>\n\n\n\n<li>Exacerbation of skin manifestations of psoriasis or eczema<\/li>\n\n\n\n<li>Reactions at injection sites<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Leberstoffwechsel_und_Arzneimittelinteraktionen\"><\/span><strong>Liver metabolism and drug interactions<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Some essential oils affect cytochrome P450 enzymes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Potential interactions:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Oils with CYP enzyme induction\/inhibition:<\/strong> Peppermint, grapefruit, bergamot<\/li>\n\n\n\n<li><strong>Risk:<\/strong> Altered clearance of other drugs (but not of the biologics themselves, as these are proteolytically degraded)<\/li>\n\n\n\n<li><strong>Clinical relevance:<\/strong> More relevant with concomitant use of DMARDS (e.g. methotrexate)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Spezifische_Uberlegungen_zu_Immunsuppressiva\"><\/span>Specific considerations for immunosuppressants<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TNF-%CE%B1-Inhibitoren_Atherische_Ole\"><\/span>TNF-\u03b1 inhibitors + essential oils<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Moderate risks:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Frankincense: Could have additive anti-inflammatory effects, but could also increase immunosuppression<\/li>\n\n\n\n<li>Ginger: Relatively safe, predominantly symptomatic effect<\/li>\n\n\n\n<li>Turmeric: caution with high doses, note the risk of bleeding<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Recommendation:<\/strong> Topical application probably safe, discuss oral supplementation with doctor<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Interleukin-Inhibitoren_Atherische_Ole\"><\/span>Interleukin inhibitors + essential oils<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Take special care:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>IL-17 inhibitors increase the risk of candidiasis: antifungal oils such as tea tree oil could theoretically help, but caution when applied to the skin<\/li>\n\n\n\n<li>IL-6 inhibitors: Increased risk of infection, no strong immunosuppressive oils<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"B-Zell-Depletoren_Rituximab\"><\/span>B-cell depletors (rituximab)<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Extreme caution:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Strongly immunosuppressive<\/li>\n\n\n\n<li>Long-term immunosuppression (6-12 months)<\/li>\n\n\n\n<li>Avoid all potentially immunomodulating essential oils in therapeutic doses<\/li>\n\n\n\n<li>Only mild, symptomatic oils in low doses (lavender for relaxation)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Praktische_Empfehlungen\"><\/span>Practical recommendations<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Sichere_Anwendung_bei_Biologika-Therapie\"><\/span>Safe use with biologics therapy:<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Always discuss with the treating rheumatologist\/gastroenterologist<\/strong><\/li>\n\n\n\n<li><strong>Preferred topical application<\/strong> (lower systemic absorption)<\/li>\n\n\n\n<li><strong>Use low concentrations<\/strong> (1-2% in carrier oil)<\/li>\n\n\n\n<li><strong>Antimicrobial oils:<\/strong> Only if specifically required and in consultation<\/li>\n\n\n\n<li><strong>Avoid immunostimulant oils<\/strong> during active biologics therapy<\/li>\n\n\n\n<li><strong>Perform patch test<\/strong> due to increased skin sensitivity<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Relative_Sicherheit_%E2%80%93_Empfohlene_Ole\"><\/span>Relative safety - Recommended oils:<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Lavender:<\/strong> Relaxation, sleep promotion<\/li>\n\n\n\n<li><strong>Camomile:<\/strong> Anti-inflammatory, calming<\/li>\n\n\n\n<li><strong>Peppermint:<\/strong> Symptomatic pain relief (topical, diluted)<\/li>\n\n\n\n<li><strong>Ginger:<\/strong> Nausea, moderate anti-inflammatory effect<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%80%A6_zu_vermeidende_oder_nur_nach_arztlicher_Rucksprache\"><\/span>... to be avoided or only after consultation with a doctor:<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Frankincense\/Myrrh:<\/strong> In high doses<\/li>\n\n\n\n<li><strong>Oregano\/thyme:<\/strong> Strongly immunomodulating<\/li>\n\n\n\n<li><strong>Tea tree oil:<\/strong> Immunostimulating<\/li>\n\n\n\n<li><strong>All oral income<\/strong> therapeutic doses<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fazit\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The interaction between essential oils and biologics has been the subject of little scientific research. The theoretical risks mainly concern increased immunosuppression and risk of infection. Topical application of mild essential oils in low concentrations is probably safe, but any application should be discussed with the treating physician. For autoimmune diseases undergoing biologic therapy, safety is paramount.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Important:<\/strong> This is not medical advice. Any use of complementary therapies for autoimmune diseases must be individually agreed with the specialist.<\/p>","protected":false},"excerpt":{"rendered":"<p>Autoimmunerkrankungen und Immunmodulation stehen in direktem Zusammenhang. Wie \u00c4therische \u00d6le immunmodulatorisch wirken, soll nachfolgend sowohl f\u00fcr medizinische Laien verst\u00e4ndlich erkl\u00e4rt, wie f\u00fcr medizinisches Fachpersonal (mittels Studien) dargelegt werden. Vorab noch drei Begriffe, deren Bedeutung gekl\u00e4rt sein soll, um m\u00f6glichen Unklarheiten zu begegnen: Autoimmunit\u00e4t Von Autoimmunit\u00e4t spricht man bei einer krankhaften (pathologischen) Immunantwort des menschlichen Organismus&hellip;&nbsp;<a href=\"https:\/\/csiag.de\/en\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/\" rel=\"bookmark\">Read More \"<span class=\"screen-reader-text\">Autoimmune disease and immunomodulation of essential oils<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"[\"title\",\"meta\",\"thumbnail\",\"content\",\"tags\",\"comments\"]","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[3401,1078,354],"tags":[5575,94,5576,5581,5537,117,5538,650,5540,5558,5578,4643,5568,3902,5566,1569,3901,5574,5573,3104,5579,5543,5562,3972,5580,5555,4819,1446,5569,5560,5542,5553,5552,5544,3323,5539,46,98,5559,1896,5548,1568,82,81,3446,5556,5583,3897,4818,4349,5545,5567,5557,5577,5550,1747,5549,5563,5582,1971,5546,5547,5572,5551,3898,5561,4437,31,5564,5571,5541,4648],"class_list":["post-11899","post","type-post","status-publish","format-standard","hentry","category-aetherische-oele","category-medizin","category-medizin-gesundheit","tag-anregend","tag-antikoerper","tag-antiseptisch","tag-aromatisch","tag-autimmunerkrankung","tag-autoantikoerper","tag-autoimmunitaet","tag-bakterien","tag-bakterium","tag-bauchspeicheldruese","tag-beruhigend","tag-blut","tag-bodenbeschaffenheit","tag-chemotyp","tag-chemotypen","tag-colitis-ulcerosa","tag-ct","tag-ct-linalool","tag-ct-thymol","tag-darm","tag-entspannend","tag-entzuendung","tag-entzuendungsstoffe","tag-erntezeitpunkt","tag-gehrin","tag-gelenke","tag-gewebe","tag-haut","tag-hoehenlage","tag-hshioto","tag-humoral","tag-il-1","tag-il-6","tag-immunantwort","tag-immunmodulation","tag-immunsuppression","tag-immunsystem","tag-immunzellen","tag-lupus","tag-lymphe","tag-lymphozyten","tag-morbus-crohn","tag-ms","tag-multiple-sklerose","tag-nase","tag-nervenhuellen","tag-nf-b","tag-olfaktorisch","tag-organe","tag-organismus","tag-pathologisch","tag-pflanzenart","tag-schilddruese","tag-schleimloesend","tag-stimulativ","tag-studien","tag-suppressiv","tag-sutdie","tag-systemisch","tag-t-lymphozyten","tag-t-zelle","tag-t-zellen","tag-thymian","tag-tnf-","tag-topisch","tag-typ-1","tag-uv-strahlung","tag-virus","tag-volltext","tag-wachstumsbedingungen","tag-zell","tag-zellulaer"],"acf":[],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/posts\/11899","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/comments?post=11899"}],"version-history":[{"count":0,"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/posts\/11899\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/media?parent=11899"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/categories?post=11899"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.de\/en\/wp-json\/wp\/v2\/tags?post=11899"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}