Synthetic mRNA Vaccines and Transcriptomic Dysregulation: Evidence from New-Onset Adverse Events and Cancers Post-Vaccination

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Updated - October 6, 2025

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Under the title "Synthetic mRNA Vaccines and Transcriptomic Dysregulation: Evidence from New-Onset Adverse Events and Cancers Post-Vaccination" (in German: "Synthetic mRNA vaccines and transcriptomic dysregulation: evidence for emerging adverse events and cancers after vaccination"Natalia von Ranke, Wei Zhang, Philipp Anokin, Nicolas Hulscher, Kevin J. McKernan, Peter A. McCullough & John A. Catanzaro on 25.07.2025 under DOI 10.20944/preprints202507/.2155.v1 on preprints.org published their study.

On 11.09.2025, the preprint was withdrawn from preprints.org, as uncutnews.ch reported in a Contribution from 15.09.2025.

As the study is currently being peer-reviewed by other renowned journals, it is still available on ResearchGate available.

In the meantime, 36,351 readers have accessed the now deleted preprint, 8,651 downloads have taken place and 22 comments have been left:

The study therefore seems to have attracted a great deal of attention in the scientific community. The fact that a preprint is withdrawn at all seems to be a rarity.

The study used differential gene expression analysis to compare healthy control subjects (803 volunteers) with people who had demonstrably been harmed by mRNA injections carried out as part of the pandemic activities (e.g. cancer and adverse events). Here as PDF for Download.

It was shown that gene expression related to thousands of genes is disrupted in the long term (over months to years after injection), e.g. mitochondrial failure (previously only known as a disruption of cellular energy production due to genetically determined, maternally inherited mitochondrial defects), such as oncogenic activation (in which intact genes are converted into pathological forms, resulting in overexpression of the oncogene product, thus leading to uncontrolled cell growth and subsequent tumor formation). This was determined by means of high-resolution RNA sequencing of blood samples.

The following effects were observed, among others:

• Mitochondrial failure
  Degradation of complex I (NADH dehydrogenase or NADH ubiquinone oxidoreductase), oxidative stress, energy breakdown
• Reprogramming of the immune system
  chronic inflammation,
  ACE2 suppression (inhibition or reduction of the activity or expression of angiotensin-converting enzyme-2),
  TLR hyperactivation (excessive or uncontrolled activation of Toll-like receptors (TLRs) results in intracellular signaling cascades triggered by dimerization, in inflammatory processes, excessive inflammatory reactions)
• Oncogenic activation
  MYC (transcription factor and the associated gene located on chromosome 8 (gene locus 8q24.21); increases the expression of other genes, the mechanism is not yet clear) increased, p53/KRAS p53 and the associated TP53 gene act as a tumor suppressor; in the event of a genetic defect within a cell, cell division is stopped and DNA repair mechanisms are set in motion. If the repair is successful, the p53 level decreases and cell division progresses. If the repair is unsuccessful, the p53 level continues to rise and activates caspases, which leads to apoptosis, or cell death; p53 also regulates the pregnancy hormone hCG (human chorionic gonadotropin),
  Suppression of DNA repair mechanisms (see above)
• Cellular stress
  Ribosome overload (caused by large amounts of mRNA to be read, damage to the mRNA, a missing stop signal blocks protein biosynthesis, resulting in an accumulation of defective or incomplete proteins that burden the cell and lead to cellular stress reactions),
  Structure of misfolded proteins (misfolded proteins are formed when an amino acid chain is not present in the biologically correct, functional three-dimensional folded structure and aggregate in the cell, whereby toxic proteins can lead to diseases such as Alzheimer's, Parkinson's, Huntington's disease),
  Activation of the proteasome (the consequence of misfolded proteins; process that attempts to break down these misfolded protein agglomerates in order to restore protein homeostasis).
• Epigenetic restructuring
  Chromatin shifts (regulates the visibility of DNA regions for transcription factors and RNA polymerase; part of complex epigenetic mechanisms that can be inherited over generations and are central to the development and adaptability of organisms),
  Methylation changes (influences the properties of genes epigenetically; genes can be inactivated or their expression reduced; these processes are reversible if the relevant methyl groups are removed by demethylation),
  Nucleosome shifting (serves to make DNA accessible for cellular processes, such as DNA replication or transcription, as the DNA cannot normally be reached by the enzymes responsible for this (DNA polymerases or RNA polymerases); the positioning of the nucleosomes on the DNA (nucleosome phasing) is important for the regulation of gene expression).
• Reverse Transcription
  Independent studies showed the occurrence of mRNA integration into DNA (gene integration of the vaccine mRNA), as well as persistent expression of the same. (According to the formulation of the central dogma of molecular biology, the flow of information is always defined from DNA to RNA).

A Systematic Review of Autopsy Findings in Deaths after COVID-19 Vaccination

A similar fate befell the 48-page study "A Systematic Review of Autopsy Findings in Deaths after COVID-19 Vaccination" from Nicolas Hulscher, Paul E. Alexander, Richard Ameling, Heather Gessling, Roger Hodkinson, William Makis, Harvey A. Risch, Mark Tozzi, Peter A. McCulloughpublished on 05.07.2023 - it was already deleted after 24 hours by The Lancet was deleted after 1,042 downloads and 2,176 views were registered within these hours.

Unfortunately, only this content is still available via WayBackMachine available:

"Abstract

Background: The rapid development and widespread deployment of COVID-19 vaccines, combined with a high number of adverse event reports, have led to concerns over possible mechanisms of injury including systemic lipid nanoparticle (LNP) and mRNA distribution, spike protein-associated tissue damage, thrombogenicity, immune system dysfunction, and carcinogenicity. The aim of this systematic review is to investigate possible causal links between COVID-19 vaccine administration and death using autopsies and post-mortem analysis. 

Methods: We searched for all published autopsy and necropsy reports relating to COVID-19 vaccination up until May 18th, 2023. We initially identified 678 studies and, after screening for our inclusion criteria, included 44 papers that contained 325 autopsy cases and one necropsy case. Three physicians independently reviewed all deaths and determined whether COVID-19 vaccination was the direct cause or contributed significantly to death. 

Findings: The most implicated organ system in COVID-19 vaccine-associated death was the cardiovascular system (53%), followed by the hematological system (17%), the respiratory system (8%), and multiple organ systems (7%). Three or more organ systems were affected in 21 cases. The mean time from vaccination to death was 14.3 days. Most deaths occurred within a week from last vaccine administration. A total of 240 deaths (73.9%) were independently adjudicated as directly due to or significantly contributed to by COVID-19 vaccination.

 Interpretation: The consistency seen among cases in this review with known COVID-19 vaccine adverse events, their mechanisms, and related excess death, coupled with autopsy confirmation and physician-led death adjudication, suggests there is a high likelihood of a causal link between COVID-19 vaccines and death in most cases. Further urgent investigation is required for the purpose of clarifying our findings.

Funding: None.

Declaration of Interest: Drs Alexander, Amerling, Hodkinson, Makis, McCullough, Risch, Trozzi are affiliated with and receive salary support and or hold equity positions in The Wellness Company, Boca Raton, FL which had no role in funding, analysis, or publication.

Keywords: autopsy, necropsy, COVID-19, COVID-19 vaccines, mRNA, SARS-CoV-2 vaccination, death, excess mortality, spike protein, organ system

Suggested Citation:

Hulscher, Nicolas and Alexander, Paul E. and Amerling, Richard and Gessling, Heather and Hodkinson, Roger and Makis, William and Risch, Harvey A. and Trozzi, Mark and McCullough, Peter A., A Systematic Review of Autopsy Findings in Deaths after COVID-19 Vaccination. Available at SSRN: https://ssrn.com/abstract=4496137 or http://dx.doi.org/10.2139/ssrn.4496137„

Conclusion

The gentle reader should think for himself about the reasons for the deletion of the above-mentioned studies and ask himself the question of how far science may still serve the establishment of truth ...