HQH granules (Huaiqihuang) for psoriasis

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HQH (Huaiqihuang) contains, among other things, the active ingredients of the Huaier fungus and is effective for proriasis (psoriasis), a hereditary, non-contagious, relapsing, chronic inflammatory autoimmune disease of the skin and joints that is considered incurable.
In addition to the Huaier active ingredients, HQH also contains active ingredients from the following herbs: Lycium barbarum (gouqi/goji berries) and Polygonatum sibiricum (Huangjing/Salomon Seal).

The inherited, pure genetic defect is not in itself the cause of the onset of psoriasis. Only additional factors, such as injuries, stress, alcohol, medication, infectious diseases, metabolic disorders, hormonal and environmental influences can cause the onset of the disease.

While healthy skin regenerates itself within 26 ... 27 days, in psoriasis the process takes just under a week. However, as the skin cells to be replaced are still far too young and therefore not ready for rejection, they thicken and form the plaques mentioned above.

Forms of psoriasis

There are different forms of psoriasis with varying degrees of severity:

• Psoriasis geographica
  Named because of their shape - outlines resembling those of countries on a world map: large contiguous psoriasis foci

• Psoriasis palmaris et plantaris
  Named after the place of occurrence: palmaris (palm of the hand), plantaris (soles of the feet)

• Psoriasis punctata
  Named after its appearance, the size of a matchstick head, punctual psoriasis foci distributed over the entire trunk

• Pustular psoriasis
  Named after the appearance of purulent pustules
• Psoriasis vulgaris
  Large areas of psoriasis, conspicuous silvery scaling with a narrow, red border around the edge

Common to all forms is the presence of increased concentrations of pro-inflammatory proteins in the affected areas.

Therapy approach

The therapeutic approach of HQH granules in mild to moderate psoriasis was already tested in August 2018 in a randomized, double-blind, controlled trial. study on First Affiliated Hospital the Harbin Medical University, The results were tested both experimentally on HaCaT cells (a type of human cell cultivated to determine the efficacy of various substances; used as a central model in dermatological research) and on patients.
In December 2025, this confirmed study the efficacy of Huaier on keratocyte proliferation and inflammatory responses: „... (STAT1) regulation was associated with decreased expression of pro-inflammatory cytokines, including interleukin-17A and tumor necrosis factor alpha ...“

The - study-typical - formulation of the research results reads (quote from the above link):

... effectively inhibited the proliferation of Hacat cells and induced cell cycle arrest. Efficacy and safety in patients with psoriasis were observed in clinical trials. Huaier has shown promising effects in both experimental and clinical settings in this preliminary study and may provide some benefit in the treatment of psoriasis vulgaris in the future.

The concrete Photo of a patient before, after two and four weeks of treatment is convincing, even for the medical layman (erythema, desquamation and infiltration significantly reduced):

The laboratory results of the relevant values after four weeks of treatment confirm the visual impression in the laboratory (before -> after):

• PASI (Psoriasis Area and Severity Index) 8.0 -> 1.8
• BSA (Psoriasis Area and Severity Index) 2.8 -> 2.5%
• sPGA (static Physician Global Assessment) 3 -> 0
• DLQI (Dermatology Life Quality Index) 7 -> 1.0

Another patient had the following laboratory values:

• PASI 8.0 -> 0.5
• BSA 6.8% -> 0.2%
• sPGA 3 -> 0
• DLQI 9.0 -> 0

Side effects in the form of flatulence and diarrhea occurred in only 2 of 84 test subjects within three days of starting treatment. Furthermore, no deviations in other vital parameters were recorded compared to the period before treatment.

The dosage for the HQH granules (Huaiqihuang) resulting from the study data is 2x 10g daily for 4 to 8 weeks.
In the study, HQH was analyzed together with Yinxie granules which had an age-specific dosage of 6g ( 70 kg).

Since the Huaier fungus, whose active ingredients are also contained in HQH, only has the keratogenic aspects (Keratinocytes), but does not interfere with the immunological feedback loops that are central to psoriasis chronicity (BMC Complementary Medicine and TherapiesPubMed) and no direct anti-inflammatory effect on cytokines, as well as T-cell modulation monotherapy in multifactorial disease, the combination therapy used in the study is specifically more effective here.

1. Synergistic mechanisms of action

Huaier alone:

• Blocks keratinocyte proliferation in the G1 phase cycle Nature
• Direct antiproliferative effect

Lycium barbarum (Goji) adds:

• Reduces TNF-α and IL-6, inhibits NF-κB activation PubMed CentralNature
• Dual action: both pro- and anti-inflammatory, which creates immune balance ScienceDirect
• Activates macrophages via NF-κB and AP-1 PubMed

Polygonatum sibiricum (Huangjing) adds:

• Increases IL-2, IFN-γ, IgM and IgA; improves CD4+/CD8+ T-cell ratio PubMed Central
• Promotes dendritic cell maturation and Th1 immune response PubMed Central

2. Covering the complex pathogenesis of psoriasis

Psoriasis is not only keratinocyte hyperproliferation, but also:

• Activation of STAT3, NF-κB, cytokine production BMC Complementary Medicine and TherapiesPubMed Central
• Self-reinforcing inflammatory cycle between keratinocytes and T cells PubMed
• IFN-γ, TNF, IL-17A and IL-22 promote keratinocyte proliferation AND inflammation ResearchGate

Source of supply

… to be continued …